Q6LYU3 (GUAAB_METMP) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 51.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: GMP synthase [glutamine-hydrolyzing] subunit B EC=6.3.5.2 Alternative name(s): GMP synthetase | ||||||
| Gene names |
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| Organism | Methanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 267377 [NCBI] | ||||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus |
Protein attributes
| Sequence length | 310 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00345 |
| Catalytic activity | ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00345 |
| Pathway | Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00345 |
| Subunit structure | Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential. |
| Sequence similarities | Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | GMP biosynthesis Purine biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | GMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GMP synthase (glutamine-hydrolyzing) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 310 | 310 | GMP synthase [glutamine-hydrolyzing] subunit B HAMAP MF_00345 | PRO_0000140244 | |||||
Regions | |||||||||
| Domain | 2 – 185 | 184 | GMPS ATP-PPase | ||||||
| Nucleotide binding | 29 – 35 | 7 | ATP By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis." Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. Leigh J.A.J. Bacteriol. 186:6956-6969(2004) [PubMed: 15466049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S2 / LL. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX950229 Genomic DNA. Translation: CAF30450.1. |
| RefSeq | NP_988014.1. NC_005791.1. |
3D structure databases | |
| ProteinModelPortal | Q6LYU3. |
| SMR | Q6LYU3. Positions 5-310. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2761428. |
| GenomeReviews | Gene locus MMP0894 in contig BX950229_GR. |
| KEGG | mmp:MMP0894. |
| NMPDR | fig|267377.1.peg.894. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG391775. |
| OMA | QGTIAPD. |
| ProtClustDB | PRK00919. |
Enzyme and pathway databases | |
| BioCyc | MMAR267377:MMP0894-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00345. GMP_synthase_B. [Tree] |
| InterPro | IPR001674. GMP_synth_C. IPR022310. NAD/GMP_synthase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| KO | K01951. |
| Pfam | PF00958. GMP_synt_C. 1 hit. PF02540. NAD_synthase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00884. GuaA_Cterm. 1 hit. |
| PROSITE | PS51553. GMPS_ATP_PPASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GUAAB_METMP | ||||||||
| Accession | Primary (citable) accession number: Q6LYU3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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