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Q6LYS1 (DAPF_METMP) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Diaminopimelate epimerase
Short name=DAP epimerase
EC=5.1.1.7
Gene names
Name:dapF
Ordered Locus Names:MMP0917
OrganismMethanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]
Taxonomic identifier267377 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP MF_00197

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. HAMAP MF_00197

Subcellular location

Cytoplasm By similarity HAMAP MF_00197.

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlysine biosynthetic process via diaminopimelate

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondiaminopimelate epimerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Diaminopimelate epimerase HAMAP MF_00197
PRO_1000124424

Sites

Active site711 By similarity
Active site2201 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LYS1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A972AD2DD3751108

FASTA27730,835
        10         20         30         40         50         60 
MKFTKMHGLG NDYIYVDAIS QKIENPNEIS KFVSDRHFGI GSDGLVLILP SDVADFKMRM 

        70         80         90        100        110        120 
FNSDGSEAEM CGNAIRCVGK FVYDKKMTDK STITIETLAG IKVLEMTIEN GKVVLVKVDM 

       130        140        150        160        170        180 
GEPILKAEEI PVLSEKHPVI DEEITAKDYC YNFTCVSMGN PHAITYIENV DEFPLEKIGP 

       190        200        210        220        230        240 
LFEIHEKFPR KTNVEFVELI DKNTVKMRVW ERGAGETLAC GTGACAVLTA SVLKGYVGRK 

       250        260        270 
ATVKLLGGDL TIEWNEFDKH IYMTGPATTV FEGEIDI

« Hide

References

[1]"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis."
Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. expand/collapse author list , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.
J. Bacteriol. 186:6956-6969(2004) [PubMed: 15466049] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S2 / LL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX950229 Genomic DNA. Translation: CAF30473.1.
RefSeqNP_988037.1. NC_005791.1.

3D structure databases

HSSPHSSP built from PDB template 2GKE based on UniProtKB P44859.
ProteinModelPortalQ6LYS1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2761669.
GenomeReviewsGene locus MMP0917 in contig BX950229_GR.
KEGGmmp:MMP0917.
NMPDRfig|267377.1.peg.917.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG399442.
OMAFMTGPAT.
ProtClustDBPRK00450.

Enzyme and pathway databases

BioCycMMAR267377:MMP0917-MONOMER.

Family and domain databases

HAMAPMF_00197. DAP_epimerase.
[Tree]
InterProIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
KOK01778.
PfamPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsTIGR00652. DapF. 1 hit.
PROSITEPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPF_METMP
AccessionPrimary (citable) accession number: Q6LYS1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 5, 2004
Last modified: November 16, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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