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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123SubstrateUniRule annotation1
Binding sitei148SubstrateUniRule annotation1
Binding sitei178SubstrateUniRule annotation1
Binding sitei182SubstrateUniRule annotation1
Binding sitei183NADUniRule annotation1
Binding sitei235NADUniRule annotation1
Binding sitei337NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi149 – 151NADUniRule annotation3
Nucleotide bindingi212 – 217NADUniRule annotation6
Nucleotide bindingi291 – 293NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:MMP0920
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

Subcellular locationi

Q6LYR8:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001170071 – 415AdenosylhomocysteinaseAdd BLAST415

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP0920.

Structurei

3D structure databases

ProteinModelPortaliQ6LYR8.
SMRiQ6LYR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04137. Archaea.
COG0499. LUCA.
HOGENOMiHOG000227987.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG093Z03XF.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 2 hits.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LYR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVKDMSLA PSGHLKMEWA KRHMPVLCRI AEEFKNDKPF EGLTIGMALH
60 70 80 90 100
LEAKTAILAE TLLEGGAKIV ITGCNPLSTQ DDVAAACVEK GMEVYAWRGE
110 120 130 140 150
TNEEYYENLN KVLDSNPDII IDDGADLIFL IHTERTELIG KIMGGCEETT
160 170 180 190 200
TGIIRLKSMA EEGALKFPVV NVNDAYTKHL FDNRYGTGQS AMDGIIRTTN
210 220 230 240 250
LLIAGKNVVV GGYGWCGRGV ASRAAGHGAN VIITEVNPIR ALEAKMDGFT
260 270 280 290 300
VLKMEEAAKI GDIFVTTTGC KDILRMEHFL LMKDGAVLSN AGHFDNEINK
310 320 330 340 350
NDLKELSKSV KEARFNIEEY DLGNKKIYLL GEGRLVNLAC ADGHPCEVMD
360 370 380 390 400
MSFANQALSA KFIKENKGKL ENEVYEIPYE QDFKIALLKL HSMGADIDEL
410
SPEQRKYLSD WKEGT
Length:415
Mass (Da):45,834
Last modified:July 5, 2004 - v1
Checksum:i8830AF3625379A26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA. Translation: CAF30476.1.
RefSeqiWP_011170864.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF30476; CAF30476; MMP0920.
GeneIDi2761229.
KEGGimmp:MMP0920.
PATRICifig|267377.15.peg.948.

Similar proteinsi

Entry informationi

Entry nameiSAHH_METMP
AccessioniPrimary (citable) accession number: Q6LYR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families