Q6LYR8 (SAHH_METMP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenosylhomocysteinase
EC=3.3.1.1

Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name=AdoHcyase

Gene names

Name:	ahcY
Ordered Locus Names:	MMP0920

Organism

Methanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]

Taxonomic identifier

267377 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › Methanococcus maripaludis

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP-Rule MF_00563
Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP-Rule MF_00563
Cofactor	Binds 1 NAD per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP-Rule MF_00563
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 415	415	Adenosylhomocysteinase HAMAP-Rule MF_00563		PRO_0000117007
Regions
	Nucleotide binding	149 – 151	3	NAD By similarity
	Nucleotide binding	212 – 217	6	NAD By similarity
	Nucleotide binding	291 – 293	3	NAD By similarity
Sites
	Binding site	123	1	Substrate By similarity
	Binding site	148	1	Substrate By similarity
	Binding site	178	1	Substrate By similarity
	Binding site	182	1	Substrate By similarity
	Binding site	183	1	NAD By similarity
	Binding site	235	1	NAD By similarity
	Binding site	337	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LYR8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8830AF3625379A26	FASTA	415	45,834
	10 20 30 40 50 60 MSNVKDMSLA PSGHLKMEWA KRHMPVLCRI AEEFKNDKPF EGLTIGMALH LEAKTAILAE 70 80 90 100 110 120 TLLEGGAKIV ITGCNPLSTQ DDVAAACVEK GMEVYAWRGE TNEEYYENLN KVLDSNPDII 130 140 150 160 170 180 IDDGADLIFL IHTERTELIG KIMGGCEETT TGIIRLKSMA EEGALKFPVV NVNDAYTKHL 190 200 210 220 230 240 FDNRYGTGQS AMDGIIRTTN LLIAGKNVVV GGYGWCGRGV ASRAAGHGAN VIITEVNPIR 250 260 270 280 290 300 ALEAKMDGFT VLKMEEAAKI GDIFVTTTGC KDILRMEHFL LMKDGAVLSN AGHFDNEINK 310 320 330 340 350 360 NDLKELSKSV KEARFNIEEY DLGNKKIYLL GEGRLVNLAC ADGHPCEVMD MSFANQALSA 370 380 390 400 410 KFIKENKGKL ENEVYEIPYE QDFKIALLKL HSMGADIDEL SPEQRKYLSD WKEGT

References

[1]

"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis." Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A. J. Bacteriol. 186:6956-6969(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S2 / LL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950229 Genomic DNA. Translation: CAF30476.1.
RefSeq	NP_988040.1. NC_005791.1.
3D structure databases
ProteinModelPortal	Q6LYR8.
ModBase	Search...
Protein-protein interaction databases
STRING	267377.MMP0920.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAF30476; CAF30476; MMP0920.
GeneID	2761229.
KEGG	mmp:MMP0920.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0499.
HOGENOM	HOG000227987.
KO	K01251.
OMA	TIGMALH.
ProtClustDB	PRK05476.
Enzyme and pathway databases
BioCyc	MMAR267377:GJ77-950-MONOMER.
UniPathway	UPA00314; UER00076.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_00563. AdoHcyase.
InterPro	IPR000043. Adenosylhomocysteinase. IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR016040. NAD(P)-bd_dom. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view]
PANTHER	PTHR23420. PTHR23420. 1 hit.
Pfam	PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view]
PIRSF	PIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMART	SM00996. AdoHcyase. 1 hit. SM00997. AdoHcyase_NAD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00936. ahcY. 1 hit.
PROSITE	PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAHH_METMP

Accession

Primary (citable) accession number: Q6LYR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program