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Q6LYM1 (DNLI_METMP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:MMP0970
OrganismMethanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]
Taxonomic identifier267377 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573DNA ligase HAMAP-Rule MF_00407
PRO_0000059607

Sites

Active site2521N6-AMP-lysine intermediate By similarity
Binding site2501ATP By similarity
Binding site2571ATP By similarity
Binding site2721ATP By similarity
Binding site3011ATP By similarity
Binding site3421ATP By similarity
Binding site4321ATP By similarity
Binding site4381ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LYM1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 0E7E33F72388095B

FASTA57365,752
        10         20         30         40         50         60 
MLFSDFCKIL DKIEKTTKRL EKTDYFVELI DFIKTSEKPE NLKQVSQITI GRVFAEFENK 

        70         80         90        100        110        120 
EIGIGPNLLL EAVKTTGIPE KDLKSKIKET GDIGTAVENL SSNIKQVSLF SQALTLEEVY 

       130        140        150        160        170        180 
STLKKLSEIE GNSSQKKKTR IISNLLILAD PVESRYISRL ILEDMRIGMN IPTILASFSN 

       190        200        210        220        230        240 
YFNVNKESVE KIYAVTNDIG LLGEKLISGS DIENDPELKL KVFRPIKPML AQLTPSIEDA 

       250        260        270        280        290        300 
MIETKMPQFE TKYDGARVQV HKSNGDVKIY SRRLENITNS VPELVEEIKK LDIDNIILEG 

       310        320        330        340        350        360 
ECVAMDLDSG KPRPFQDILR RFRRKYNIDK MAEKIALRIY FFDVLYYNRG LIDTPLKTRR 

       370        380        390        400        410        420 
EILEKLFGTN NWDSELEKIK KEIFSSKMLF SSFKLNSGDP NLVKEFFNWS LSIGHEGIMI 

       430        440        450        460        470        480 
KNPDAPYTPG SRVKTMYKVK PTLENLDVVV TRAKIGMGKR KDWYGSYELS VKDNDGNLHV 

       490        500        510        520        530        540 
IGNVGSGLTE DDLEKLTKIV NEIKIEDLGE EVILEPKIVL EVTYEEIQTS EKYEMGYALR 

       550        560        570 
FPRVVQIRED KSINDINTLD DVKKIYEIER NRK 

« Hide

References

[1]"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis."
Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. expand/collapse author list , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.
J. Bacteriol. 186:6956-6969(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S2 / LL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950229 Genomic DNA. Translation: CAF30526.1.
RefSeqNP_988090.1. NC_005791.1.

3D structure databases

ProteinModelPortalQ6LYM1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267377.MMP0970.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF30526; CAF30526; MMP0970.
GeneID2761378.
KEGGmmp:MMP0970.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAGRPRPFQ.
ProtClustDBCLSK876100.

Enzyme and pathway databases

BioCycMMAR267377:GJ77-1000-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_METMP
AccessionPrimary (citable) accession number: Q6LYM1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families