Q6LY06 (FUCA_METMP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-fuculose phosphate aldolase
EC=4.1.2.17

Alternative name(s):
L-fuculose-1-phosphate aldolase

Gene names

Name:	fucA
Ordered Locus Names:	MMP1187

Organism

Methanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]

Taxonomic identifier

267377 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › Methanococcus maripaludis

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible aldol cleavage of L-fuculose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde By similarity.
Catalytic activity	L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.
Cofactor	Binds 1 zinc ion per subunit Potential.
Pathway	Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3. Cofactor biosynthesis; coenzyme F420 biosynthesis.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the aldolase class II family. AraD/FucA subfamily.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fucose catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	L-fuculose-phosphate aldolase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	L-fuculose phosphate aldolase		PRO_0000342597
Sites
	Metal binding	68	1	Zinc By similarity
	Metal binding	87	1	Zinc By similarity
	Metal binding	89	1	Zinc By similarity
	Metal binding	147	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LY06 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8EBD09B72341687D	FASTA	180	20,110
	10 20 30 40 50 60 MDLTEFIKIC RLLYDRKYVV GSGGNVSIRD GNLIYITPTG LSLGFLTKED ICIADLNGNI 70 80 90 100 110 120 IKGKPTSELN MHLKIYQNKD SINAVVHTHS MYCTAFSALD KKLKLVTPEA EMVVKKIAYV 130 140 150 160 170 180 DYFPCGSLEL AENVSECIED SIILKNHGIV TLGKDITEAY IKTEVLEEVA QLNYIMNNLK

References

[1]

"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis." Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A. J. Bacteriol. 186:6956-6969(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S2 / LL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950229 Genomic DNA. Translation: CAF30743.1.
RefSeq	NP_988307.1. NC_005791.1.
3D structure databases
ProteinModelPortal	Q6LY06.
ModBase	Search...
Protein-protein interaction databases
STRING	267377.MMP1187.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAF30743; CAF30743; MMP1187.
GeneID	2762613.
KEGG	mmp:MMP1187.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0235.
HOGENOM	HOG000218182.
KO	K01628.
OMA	STELRMH.
ProtClustDB	CLSK876567.
Enzyme and pathway databases
BioCyc	MMAR267377:GJ77-1218-MONOMER.
UniPathway	UPA00071. UPA00563; UER00626.
Family and domain databases
Gene3D	3.40.225.10. 1 hit.
InterPro	IPR001303. Aldolase_II/adducin_N. [Graphical view]
Pfam	PF00596. Aldolase_II. 1 hit. [Graphical view]
SMART	SM01007. Aldolase_II. 1 hit. [Graphical view]
SUPFAM	SSF53639. Aldolase_II_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUCA_METMP

Accession

Primary (citable) accession number: Q6LY06

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program