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Protein

L-fuculose phosphate aldolase

Gene

fucA

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible aldol cleavage of L-fuculose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.By similarity

Catalytic activityi

L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Pathway: L-fucose degradation

This protein is involved in step 3 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. L-fuculose phosphate aldolase (fucA)
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Pathway: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681ZincBy similarity
Metal bindingi87 – 871ZincBy similarity
Metal bindingi89 – 891ZincBy similarity
Metal bindingi147 – 1471ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMMAR267377:GJ77-1218-MONOMER.
UniPathwayiUPA00071.
UPA00563; UER00626.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculose phosphate aldolase (EC:4.1.2.17)
Alternative name(s):
L-fuculose-1-phosphate aldolase
Gene namesi
Name:fucA
Ordered Locus Names:MMP1187
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000590 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180L-fuculose phosphate aldolasePRO_0000342597Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi267377.MMP1187.

Structurei

3D structure databases

ProteinModelPortaliQ6LY06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0235.
HOGENOMiHOG000218182.
KOiK01628.
OMAiEWRMHVA.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiIPR001303. Aldolase_II/adducin_N.
[Graphical view]
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LY06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLTEFIKIC RLLYDRKYVV GSGGNVSIRD GNLIYITPTG LSLGFLTKED
60 70 80 90 100
ICIADLNGNI IKGKPTSELN MHLKIYQNKD SINAVVHTHS MYCTAFSALD
110 120 130 140 150
KKLKLVTPEA EMVVKKIAYV DYFPCGSLEL AENVSECIED SIILKNHGIV
160 170 180
TLGKDITEAY IKTEVLEEVA QLNYIMNNLK
Length:180
Mass (Da):20,110
Last modified:July 5, 2004 - v1
Checksum:i8EBD09B72341687D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA. Translation: CAF30743.1.
RefSeqiNP_988307.1. NC_005791.1.
WP_011171131.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF30743; CAF30743; MMP1187.
GeneIDi2762613.
KEGGimmp:MMP1187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA. Translation: CAF30743.1.
RefSeqiNP_988307.1. NC_005791.1.
WP_011171131.1. NC_005791.1.

3D structure databases

ProteinModelPortaliQ6LY06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267377.MMP1187.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF30743; CAF30743; MMP1187.
GeneIDi2762613.
KEGGimmp:MMP1187.

Phylogenomic databases

eggNOGiCOG0235.
HOGENOMiHOG000218182.
KOiK01628.
OMAiEWRMHVA.

Enzyme and pathway databases

UniPathwayiUPA00071.
UPA00563; UER00626.
BioCyciMMAR267377:GJ77-1218-MONOMER.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiIPR001303. Aldolase_II/adducin_N.
[Graphical view]
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S2 / LL.

Entry informationi

Entry nameiFUCA_METMP
AccessioniPrimary (citable) accession number: Q6LY06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.