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Q6LXQ4 (G6PI_METMP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:MMP1295
OrganismMethanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]
Taxonomic identifier267377 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Probable glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180781

Sites

Active site2801Proton donor By similarity
Active site3011 By similarity
Active site4101 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LXQ4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 673BF4111B45FE49

FASTA43849,256
        10         20         30         40         50         60 
MNGELSFKYD NVMEENLGNL GISNGKLESF NNESSKIIEI LKEKELNGEF GFLDVLNDNL 

        70         80         90        100        110        120 
DKYYELNEYS KNFENILIIG IGGSNLGLRA AETGILGSFT SRYEIPRIYY MDNSDPEKTH 

       130        140        150        160        170        180 
DILSNIDLEK TLVFVISKSG NTVETLANFF IVRNLMKKKN IDLEKHVVSI TSGGELEKIT 

       190        200        210        220        230        240 
KKENYIHFEV PENVGGRFSV LSSVGIAPLS CTSVDIKKLI DGAKSIEKSC KCEDIFKNPA 

       250        260        270        280        290        300 
LMNAVIHKLM YNRGKTVSVM MPYIERLRSF GMWYGQLWAE SLGKNGFGQT PVIAVGATSQ 

       310        320        330        340        350        360 
HSQLQLYMDG PNDKIATFLK VNKYRNDLKI EYEYDHHLSG HNLSEVITSE LVGTENSMKH 

       370        380        390        400        410        420 
NNIPNVKITL SKLNEITMGK LFLMYEMQTA ISGELYGINA FDQPAVEYGK KIAHECLTGS 

       430 
KVDSENKYIN GKYIITSK 

« Hide

References

[1]"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis."
Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. expand/collapse author list , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.
J. Bacteriol. 186:6956-6969(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S2 / LL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950229 Genomic DNA. Translation: CAF30851.1.
RefSeqNP_988415.1. NC_005791.1.

3D structure databases

ProteinModelPortalQ6LXQ4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267377.MMP1295.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF30851; CAF30851; MMP1295.
GeneID2761531.
KEGGmmp:MMP1295.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000100402.
KOK01810.
OMADWYRQLW.
ProtClustDBPRK00973.

Enzyme and pathway databases

BioCycMMAR267377:GJ77-1329-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_METMP
AccessionPrimary (citable) accession number: Q6LXQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways