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Protein

Probable glucose-6-phosphate isomerase

Gene

pgi

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei280Proton donorUniRule annotation1
Active sitei301UniRule annotation1
Active sitei410UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMMAR267377:G1G3S-1337-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:MMP1295
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807811 – 438Probable glucose-6-phosphate isomeraseAdd BLAST438

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP1295

Structurei

3D structure databases

ProteinModelPortaliQ6LXQ4
SMRiQ6LXQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00052 Archaea
COG0166 LUCA
HOGENOMiHOG000100402
KOiK01810
OMAiTNSQHAF
OrthoDBiPOG093Z02EA

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LXQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGELSFKYD NVMEENLGNL GISNGKLESF NNESSKIIEI LKEKELNGEF
60 70 80 90 100
GFLDVLNDNL DKYYELNEYS KNFENILIIG IGGSNLGLRA AETGILGSFT
110 120 130 140 150
SRYEIPRIYY MDNSDPEKTH DILSNIDLEK TLVFVISKSG NTVETLANFF
160 170 180 190 200
IVRNLMKKKN IDLEKHVVSI TSGGELEKIT KKENYIHFEV PENVGGRFSV
210 220 230 240 250
LSSVGIAPLS CTSVDIKKLI DGAKSIEKSC KCEDIFKNPA LMNAVIHKLM
260 270 280 290 300
YNRGKTVSVM MPYIERLRSF GMWYGQLWAE SLGKNGFGQT PVIAVGATSQ
310 320 330 340 350
HSQLQLYMDG PNDKIATFLK VNKYRNDLKI EYEYDHHLSG HNLSEVITSE
360 370 380 390 400
LVGTENSMKH NNIPNVKITL SKLNEITMGK LFLMYEMQTA ISGELYGINA
410 420 430
FDQPAVEYGK KIAHECLTGS KVDSENKYIN GKYIITSK
Length:438
Mass (Da):49,256
Last modified:July 5, 2004 - v1
Checksum:i673BF4111B45FE49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF30851.1
RefSeqiWP_011171239.1, NC_005791.1

Genome annotation databases

EnsemblBacteriaiCAF30851; CAF30851; MMP1295
GeneIDi2761531
KEGGimmp:MMP1295
PATRICifig|267377.15.peg.1328

Similar proteinsi

Entry informationi

Entry nameiG6PI_METMP
AccessioniPrimary (citable) accession number: Q6LXQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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