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Protein

IMP cyclohydrolase

Gene

purO

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.UniRule annotation

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purOUniRule annotation
Ordered Locus Names:MMP1310
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491621 – 201IMP cyclohydrolaseAdd BLAST201

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP1310.

Structurei

3D structure databases

ProteinModelPortaliQ6LXN9.
SMRiQ6LXN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04727. Archaea.
COG3363. LUCA.
HOGENOMiHOG000015497.
KOiK11176.
OMAiYNTPRIA.
OrthoDBiPOG093Z0CY5.

Family and domain databases

Gene3Di3.60.20.20. 1 hit.
HAMAPiMF_00705. IMP_cyclohydrol. 1 hit.
InterProiView protein in InterPro
IPR010191. IMP_cyclohydrolase.
IPR020600. IMP_cyclohydrolase-like.
IPR036795. IMP_cyclohydrolase-like_sf.
PfamiView protein in Pfam
PF07826. IMP_cyclohyd. 1 hit.
PIRSFiPIRSF004866. IMP_cclhdr_arch. 1 hit.
SUPFAMiSSF75569. SSF75569. 1 hit.
TIGRFAMsiTIGR01922. purO_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LXN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIGRFLVLG KTDEGNPFVT YRVSSRSFPN RVAKVMNDET VAILPKDLEE
60 70 80 90 100
MFKNPYITYN CVKLVGDVAV ATNGSHTDII ADKIKLGLPI RDALSYSLLT
110 120 130 140 150
MDYEKDDYNT PRIAVVITKD EAYMGYVTDS DVRIKKVELE AGKAYYLSVY
160 170 180 190 200
EACKITEHQV ISVTGKTAEE VTKFVMDYEE FEKPVTAATV LVKDGFKLAT

I
Length:201
Mass (Da):22,582
Last modified:July 5, 2004 - v1
Checksum:iDDF823A30FB88A52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA. Translation: CAF30866.1.
RefSeqiWP_011171254.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF30866; CAF30866; MMP1310.
GeneIDi2762594.
KEGGimmp:MMP1310.
PATRICifig|267377.15.peg.1345.

Similar proteinsi

Entry informationi

Entry nameiPURO_METMP
AccessioniPrimary (citable) accession number: Q6LXN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families