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Protein

Lactaldehyde dehydrogenase

Gene

MMP1487

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.By similarity

Catalytic activityi

(S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH.

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei240PROSITE-ProRule annotation1
Active sitei274PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 225NADBy similarity6

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactaldehyde dehydrogenase (EC:1.2.1.22)
Gene namesi
Ordered Locus Names:MMP1487
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003425921 – 465Lactaldehyde dehydrogenaseAdd BLAST465

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi267377.MMP1487.

Structurei

3D structure databases

ProteinModelPortaliQ6LX65.
SMRiQ6LX65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiarCOG01252. Archaea.
COG1012. LUCA.
HOGENOMiHOG000271509.
KOiK19266.
OMAiYEFFTEV.
OrthoDBiPOG093Z01H3.

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
PfamiView protein in Pfam
PF00171. Aldedh. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiView protein in PROSITE
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LX65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIDGKWIIR EDIDVFDPYT LENIEKITAL DREETKNAIE VTEKHKEIMK
60 70 80 90 100
NLSPSKRYKI LMKVAEHLSS KKDFFAKTIS IDVGKPIKQS KIEVDRTLTA
110 120 130 140 150
LKLSAFYAKE LRGETINSEN GLIFTKKEPL GVIGAITPFN FPLNLATHKI
160 170 180 190 200
GPAIATGNSV VLHPSSKAPI VAIYLTKIIE HVLKQMDIPR GVFNLATGNG
210 220 230 240 250
EIVGDEISKN DNVNMVSFTG SVEVGESISK NAKMKKVTLE LGGNNPMIVL
260 270 280 290 300
KDSDIKLAAK SAVKSKFLNA GQVCISVGQV LVEEEVVETF TKYVIEETKK
310 320 330 340 350
LILGNPLDKN TDIGPLISPE SALRIENLIK QSVSEGGELL IGGNRQNSLI
360 370 380 390 400
SPAVINIDEE NILSKIETFG PILPILTVKD SEEAVNIANN SKYGLQAGLF
410 420 430 440 450
TNNINNAMKI ADELEYGGIM INSSPTFRKD NMPFGGVKKS GLGREGIKYT
460
VEEMSETKTV VIHNI
Length:465
Mass (Da):50,981
Last modified:July 5, 2004 - v1
Checksum:iA70FE58C9B30D8A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA. Translation: CAF31043.1.
RefSeqiWP_011171431.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF31043; CAF31043; MMP1487.
GeneIDi2762736.
KEGGimmp:MMP1487.
PATRICifig|267377.15.peg.1523.

Similar proteinsi

Entry informationi

Entry nameiLADH_METMP
AccessioniPrimary (citable) accession number: Q6LX65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families