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Q6LX63

- NPPNK_METMP

UniProt

Q6LX63 - NPPNK_METMP

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Protein

Bifunctional NADP phosphatase/NAD kinase

Gene

MMP1489

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP By similarity.By similarity

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation
NADP+ + H2O = NAD+ + phosphate.

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Magnesium 1By similarity
Metal bindingi85 – 851Magnesium 1By similarity
Metal bindingi85 – 851Magnesium 2By similarity
Metal bindingi88 – 881Magnesium 2By similarity
Binding sitei88 – 881SubstrateBy similarity
Metal bindingi229 – 2291Magnesium 2By similarity
Active sitei355 – 3551Proton acceptorUniRule annotation
Binding sitei360 – 3601NADUniRule annotation
Binding sitei441 – 4411NADUniRule annotation
Binding sitei458 – 4581NADUniRule annotation
Binding sitei460 – 4601NADUniRule annotation
Binding sitei468 – 4681NAD; via carbonyl oxygenUniRule annotation
Binding sitei528 – 5281NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi355 – 3562NADUniRule annotation
Nucleotide bindingi430 – 4312NADUniRule annotation
Nucleotide bindingi471 – 4766NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. NAD+ kinase activity Source: UniProtKB
  4. NAD binding Source: UniProtKB
  5. NADP phosphatase activity Source: UniProtKB

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. lysine metabolic process Source: InterPro
  3. NAD metabolic process Source: InterPro
  4. NADP biosynthetic process Source: InterPro
  5. phosphatidylinositol phosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR267377:GJ77-1527-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional NADP phosphatase/NAD kinase
Including the following 2 domains:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Poly(P)-dependent NAD kinase
Short name:
PPNK
NADP phosphatase (EC:3.1.3.-)
Short name:
NADPase
Short name:
pNPPase
Gene namesi
Ordered Locus Names:MMP1489
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000590: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Bifunctional NADP phosphatase/NAD kinasePRO_0000229718Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi267377.MMP1489.

Structurei

3D structure databases

ProteinModelPortaliQ6LX63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 283283NADP phosphataseAdd
BLAST
Regioni275 – 566292NAD kinaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the inositol monophosphatase family.Curated
In the C-terminal section; belongs to the NAD kinase family.Curated

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000253998.
KOiK00858.
OMAiVIVPICP.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR021175. Bifunctional_PpnK_predicted.
IPR000760. Inositol_monophosphatase.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
PF01513. NAD_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF036641. Bifunctional_PpnK_predicted. 1 hit.
PRINTSiPR00377. IMPHPHTASES.
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LX63-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDMLEMALNI AKDIEKSVKP LIGWEKSNEV VKIGADGTPT KRIDLIAENV
60 70 80 90 100
AINSIEKVCS AILISEEIGF KRIGKNKPEY VIVLDPVDGT YNSLKDIPFY
110 120 130 140 150
SAAVAIGRID KFADNLEELI NNLKMKDLEV GVVRNIATGD TYYAEKGKGA
160 170 180 190 200
HFLRKGEKKS ISISNSSNLK DSSIGLFAHD ISIDTLKFIK DRRFRRIRLF
210 220 230 240 250
GSIALEMCYV AKGALDAFIN VNETTRLCDI AAGYVIIKEA GGIVTDKNGQ
260 270 280 290 300
EVNLDLDVNS KVSVICSNEM LHKKLVGIFG NRWRIKPTNF GIISRIDNEE
310 320 330 340 350
SIEVADNVIK YLDSKGIKYE LDSSTYNALK NRLTKKCDII SNIEEISHMI
360 370 380 390 400
SIGGDGTVLR ASKMIEGNEI PMVCINMGTV GFLTEFNKDE IFSAIDSIIC
410 420 430 440 450
GSYKVEKRTK LMGFAKLSDG KQHILNDSLN EVVITTKNPA KMMHFEVYID
460 470 480 490 500
GSLVEDVRAD GIIVSTPNGS TAYSLSSGGP IIEPTVEGFV IVPICPFKLS
510 520 530 540 550
SRPLVVNANS EIKIKLLKKS TYVVIDGNTE FEAKKGDEII LRKSESNAYF
560
VKGDNFYNKL KKLSLM
Length:566
Mass (Da):62,594
Last modified:July 5, 2004 - v1
Checksum:i1BE5DAC1288E60B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF31045.1.
RefSeqiNP_988609.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF31045; CAF31045; MMP1489.
GeneIDi2761729.
KEGGimmp:MMP1489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF31045.1 .
RefSeqi NP_988609.1. NC_005791.1.

3D structure databases

ProteinModelPortali Q6LX63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267377.MMP1489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF31045 ; CAF31045 ; MMP1489 .
GeneIDi 2761729.
KEGGi mmp:MMP1489.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000253998.
KOi K00858.
OMAi VIVPICP.

Enzyme and pathway databases

BioCyci MMAR267377:GJ77-1527-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR021175. Bifunctional_PpnK_predicted.
IPR000760. Inositol_monophosphatase.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF00459. Inositol_P. 1 hit.
PF01513. NAD_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036641. Bifunctional_PpnK_predicted. 1 hit.
PRINTSi PR00377. IMPHPHTASES.
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S2 / LL.

Entry informationi

Entry nameiNPPNK_METMP
AccessioniPrimary (citable) accession number: Q6LX63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3