Reviewed, UniProtKB/Swiss-Prot Q6LWX2 (PDAD_METMP)

Names and origin

Protein names

Recommended name:
    Pyruvoyl-dependent arginine decarboxylase
      Short name=PvlArgDC
    EC=4.1.1.19
Cleaved into the following 2 chains:
    1- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit beta
    2- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	pdaD
Ordered Locus Names:	MMP1582

Organism

Methanococcus maripaludis [Complete proteome] [HAMAP]

Taxonomic identifier

39152 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity.
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 51	51	Pyruvoyl-dependent arginine decarboxylase subunit beta By similarity		PRO_0000023322
	Chain	52 – 164	113	Pyruvoyl-dependent arginine decarboxylase subunit alpha By similarity		PRO_0000023323
Sites
	Site	51 – 52	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	52	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LWX2-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: FA47E589857389A8	FASTA	164	17,584
	10 20 30 40 50 60 MIKSSAIHSP FEAPNTISLV AGTGDANNPL NAFDMSLLKS GIGNLNLIRI SSIMPPKADI 70 80 90 100 110 120 IPLPKIPQGS LVPTAYGYQI SEIKGETVAA GISVAIPKDK ELCGLIMEYE CIGGKKECED 130 140 150 160 TVRNMAKEGF EMRGWEIDEI ISIASEHTVE NIGCAFAAAA LWYK

References

[1]

"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis." Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A. J. Bacteriol. 186:6956-6969(2004) [PubMed: 15466049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S2 / LL.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX950229 Genomic DNA. Translation: CAF31138.1.
RefSeq	NP_988702.1.
3D structure databases
SMR	Q6LWX2. Positions 7-164.
ModBase	Search...
Genome annotation databases
GeneID	2761980.
GenomeReviews	Gene locus MMP1582 in contig BX950229_GR.
KEGG	mmp:MMP1582.
NMPDR	fig|267377.1.peg.1582.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6LWX2.
OMA	LVPTAYG.
Enzyme and pathway databases
BioCyc	MMAR267377:MMP1582-MON.
BRENDA	4.1.1.19. 20956.
Family and domain databases
HAMAP	MF_01404. [Tree]
InterPro	IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. DUF44. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00286. PvlArgDC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD_METMP

Accession

Primary (citable) accession number: Q6LWX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)