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Q6LWM9

- GLMS_METMP

UniProt

Q6LWM9 - GLMS_METMP

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, MMP1680
Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.1 Publication

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.1 Publication

pH dependencei

Active from pH 6.5 to 7.8.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei594 – 5941For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: CACAO

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciMMAR267377:GJ77-1728-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:MMP1680
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000590: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 599598Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000333235Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi267377.MMP1680.

Structurei

3D structure databases

ProteinModelPortaliQ6LWM9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 223222Glutamine amidotransferase type-2
Add
BLAST
Domaini286 – 423138SIS 1
Add
BLAST
Domaini452 – 589138SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF13537. GATase_7. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6LWM9-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIIGYIGN EKASKILLKG LKRLEYRGYD SCGIATIDDT IKLKKNTGKV    50
LEVSKKENFE DMTGFIGIGH SRWATHGGIT KNNAHPHYDC SEKICIAHNG 100
IISNYKELKE LLISKGHIFK SETDTEVIPH LIEEEIKDFK EITEKTYINA 150
IQNTIKKLNG TYALLILNQD FPEMLVGVRN ESPLILGIKK DECFIGSDIS 200
AFLEYTKLAM PLNDRDIVIL RKENDEIDIE VLNYGKQVQR DTIELQWDME 250
SAEKEGYEHF MLKEIMEEPV ILKNSMKISK LEIENLGKEI EKCDKIYITA 300
MGTSLHAAMV AEYWFSGLNK LVIPIDSSEF LTKGIVDEKT LVIAITQSGE 350
TYDTMKAVKY AKEKGAKTAT IVNVLGSTAT READITIMMG SGLEIAVCAT 400
KTFMSQLVIL YRLFIEYGKI IGKNMDIFEK ELLNIPNYIS KVLDEKENIS 450
KIAEELTAKN YLFISKGINL ANALEGALKF KEITYLHAEG MSSGFLKHGT 500
ISLIDENMDT VALIPPSKSE LLNSVLSNVE EIKARNGKII GISPVEDNLK 550
YSIKVPDVIE EVSPFVYATA CQLLAYYKAV DLKRDVDKPR GLAKSVTVE 599
Length:599
Mass (Da):67,138
Last modified:May 20, 2008 - v2
Checksum:i872D121EDC1F106F
GO

Sequence cautioni

The sequence CAF31236.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF31236.1. Different initiation.
RefSeqiNP_988800.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF31236; CAF31236; MMP1680.
GeneIDi2762284.
KEGGimmp:MMP1680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF31236.1 . Different initiation.
RefSeqi NP_988800.1. NC_005791.1.

3D structure databases

ProteinModelPortali Q6LWM9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267377.MMP1680.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF31236 ; CAF31236 ; MMP1680 .
GeneIDi 2762284.
KEGGi mmp:MMP1680.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.

Enzyme and pathway databases

BioCyci MMAR267377:GJ77-1728-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF13537. GATase_7. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S2 / LL.
  2. "Acetamido sugar biosynthesis in the Euryarchaea."
    Namboori S.C., Graham D.E.
    J. Bacteriol. 190:2987-2996(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, PH DEPENDENCE, SUBUNIT.
    Strain: 900.

Entry informationi

Entry nameiGLMS_METMP
AccessioniPrimary (citable) accession number: Q6LWM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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