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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.1 Publication

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.1 Publication

pH dependencei

Active from pH 6.5 to 7.8.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityBy similarity1
Active sitei594For Fru-6P isomerization activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:MMP1680
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

Subcellular locationi

Q6LWM9:

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003332352 – 599Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST598

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi267377.MMP1680.

Structurei

3D structure databases

ProteinModelPortaliQ6LWM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 223Glutamine amidotransferase type-2Add BLAST222
Domaini286 – 423SIS 1Add BLAST138
Domaini452 – 589SIS 2Add BLAST138

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiarCOG00057. Archaea.
COG0449. LUCA.
HOGENOMiHOG000258896.
KOiK00820.
OMAiASEYRYA.
OrthoDBiPOG093Z014P.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6LWM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIIGYIGN EKASKILLKG LKRLEYRGYD SCGIATIDDT IKLKKNTGKV
60 70 80 90 100
LEVSKKENFE DMTGFIGIGH SRWATHGGIT KNNAHPHYDC SEKICIAHNG
110 120 130 140 150
IISNYKELKE LLISKGHIFK SETDTEVIPH LIEEEIKDFK EITEKTYINA
160 170 180 190 200
IQNTIKKLNG TYALLILNQD FPEMLVGVRN ESPLILGIKK DECFIGSDIS
210 220 230 240 250
AFLEYTKLAM PLNDRDIVIL RKENDEIDIE VLNYGKQVQR DTIELQWDME
260 270 280 290 300
SAEKEGYEHF MLKEIMEEPV ILKNSMKISK LEIENLGKEI EKCDKIYITA
310 320 330 340 350
MGTSLHAAMV AEYWFSGLNK LVIPIDSSEF LTKGIVDEKT LVIAITQSGE
360 370 380 390 400
TYDTMKAVKY AKEKGAKTAT IVNVLGSTAT READITIMMG SGLEIAVCAT
410 420 430 440 450
KTFMSQLVIL YRLFIEYGKI IGKNMDIFEK ELLNIPNYIS KVLDEKENIS
460 470 480 490 500
KIAEELTAKN YLFISKGINL ANALEGALKF KEITYLHAEG MSSGFLKHGT
510 520 530 540 550
ISLIDENMDT VALIPPSKSE LLNSVLSNVE EIKARNGKII GISPVEDNLK
560 570 580 590
YSIKVPDVIE EVSPFVYATA CQLLAYYKAV DLKRDVDKPR GLAKSVTVE
Length:599
Mass (Da):67,138
Last modified:May 20, 2008 - v2
Checksum:i872D121EDC1F106F
GO

Sequence cautioni

Q6LWM9: The sequence CAF31236 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA. Translation: CAF31236.1. Different initiation.
RefSeqiWP_048064125.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF31236; CAF31236; MMP1680.
GeneIDi2762284.
KEGGimmp:MMP1680.
PATRICifig|267377.15.peg.1719.

Similar proteinsi

Entry informationi

Entry nameiGLMS_METMP
AccessioniPrimary (citable) accession number: Q6LWM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 25, 2017
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome