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Q6LWM9

- GLMS_METMP

UniProt

Q6LWM9 - GLMS_METMP

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.1 Publication

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.1 Publication

    pH dependencei

    Active from pH 6.5 to 7.8.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityBy similarity
    Active sitei594 – 5941For Fru-6P isomerization activityBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: CACAO

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciMMAR267377:GJ77-1728-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferase
    GFAT
    Glucosamine-6-phosphate synthase
    Hexosephosphate aminotransferase
    L-glutamine--D-fructose-6-phosphate amidotransferase
    Gene namesi
    Name:glmS
    Ordered Locus Names:MMP1680
    OrganismiMethanococcus maripaludis (strain S2 / LL)
    Taxonomic identifieri267377 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000000590: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 599598Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000333235Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    STRINGi267377.MMP1680.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LWM9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 223222Glutamine amidotransferase type-2Add
    BLAST
    Domaini286 – 423138SIS 1Add
    BLAST
    Domaini452 – 589138SIS 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 SIS domains.Curated

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiPVTRRFM.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF13537. GATase_7. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6LWM9-1 [UniParc]FASTAAdd to Basket

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    MCGIIGYIGN EKASKILLKG LKRLEYRGYD SCGIATIDDT IKLKKNTGKV    50
    LEVSKKENFE DMTGFIGIGH SRWATHGGIT KNNAHPHYDC SEKICIAHNG 100
    IISNYKELKE LLISKGHIFK SETDTEVIPH LIEEEIKDFK EITEKTYINA 150
    IQNTIKKLNG TYALLILNQD FPEMLVGVRN ESPLILGIKK DECFIGSDIS 200
    AFLEYTKLAM PLNDRDIVIL RKENDEIDIE VLNYGKQVQR DTIELQWDME 250
    SAEKEGYEHF MLKEIMEEPV ILKNSMKISK LEIENLGKEI EKCDKIYITA 300
    MGTSLHAAMV AEYWFSGLNK LVIPIDSSEF LTKGIVDEKT LVIAITQSGE 350
    TYDTMKAVKY AKEKGAKTAT IVNVLGSTAT READITIMMG SGLEIAVCAT 400
    KTFMSQLVIL YRLFIEYGKI IGKNMDIFEK ELLNIPNYIS KVLDEKENIS 450
    KIAEELTAKN YLFISKGINL ANALEGALKF KEITYLHAEG MSSGFLKHGT 500
    ISLIDENMDT VALIPPSKSE LLNSVLSNVE EIKARNGKII GISPVEDNLK 550
    YSIKVPDVIE EVSPFVYATA CQLLAYYKAV DLKRDVDKPR GLAKSVTVE 599
    Length:599
    Mass (Da):67,138
    Last modified:May 20, 2008 - v2
    Checksum:i872D121EDC1F106F
    GO

    Sequence cautioni

    The sequence CAF31236.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950229 Genomic DNA. Translation: CAF31236.1. Different initiation.
    RefSeqiNP_988800.1. NC_005791.1.

    Genome annotation databases

    EnsemblBacteriaiCAF31236; CAF31236; MMP1680.
    GeneIDi2762284.
    KEGGimmp:MMP1680.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950229 Genomic DNA. Translation: CAF31236.1 . Different initiation.
    RefSeqi NP_988800.1. NC_005791.1.

    3D structure databases

    ProteinModelPortali Q6LWM9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267377.MMP1680.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF31236 ; CAF31236 ; MMP1680 .
    GeneIDi 2762284.
    KEGGi mmp:MMP1680.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi PVTRRFM.

    Enzyme and pathway databases

    BioCyci MMAR267377:GJ77-1728-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF13537. GATase_7. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S2 / LL.
    2. "Acetamido sugar biosynthesis in the Euryarchaea."
      Namboori S.C., Graham D.E.
      J. Bacteriol. 190:2987-2996(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, PH DEPENDENCE, SUBUNIT.
      Strain: 900.

    Entry informationi

    Entry nameiGLMS_METMP
    AccessioniPrimary (citable) accession number: Q6LWM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3