Reviewed, UniProtKB/Swiss-Prot Q6LWL8 (FWDB_METMP)

Names and origin

Protein names

Recommended name:
    Tungsten-containing formylmethanofuran dehydrogenase 2 subunit B
    EC=1.2.99.5
Alternative name(s):
    Tungsten-containing formylmethanofuran dehydrogenase II subunit B

Gene names

Name:	fwdB
Ordered Locus Names:	MMP1691

Organism

Methanococcus maripaludis [Complete proteome] [HAMAP]

Taxonomic identifier

39152 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible oxidation of CO2 and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile By similarity.
Catalytic activity	Formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor.
Cofactor	Tungsten By similarity.
Pathway	One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.
Subunit structure	This enzyme is composed of six subunits fwdA, fwdC, fwdD, fwdE, fwdF and fwdG By similarity.
Sequence similarities	Belongs to the fwdB family.

Ontologies

Keywords
Biological process	Methanogenesis
Coding sequence diversity	Selenocysteine
Ligand	Selenium Tungsten
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	formylmethanofuran dehydrogenase activity Inferred from electronic annotation. Source: EC selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Tungsten-containing formylmethanofuran dehydrogenase 2 subunit B		PRO_0000318645
Amino acid modifications
	Non-standard residue	120	1	Selenocysteine Probable

Sequences

	Sequence		Length	Mass (Da)
	Q6LWL8-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: F7CBD9D17D4F8C06	FASTA	434	48,323
	10 20 30 40 50 60 MEVFKNVVCP FCGTLCDDIE VLVENNHVVG TRNACRIGNA KFMHFEGAIR HESPLMRENK 70 80 90 100 110 120 KDDFKKVDYE TATEETARLL VEAKLPLIYG WSSAECHAQQ LGVLLAEKTK AIVDNTASVU 130 140 150 160 170 180 HGPSLLAVQD VGYPVSTLGE TKNRADVVLF WGSNPMHAHP RHMSRYSVFP RGFFRQRGKQ 190 200 210 220 230 240 DRQMIVVDPR KTDTAKLADI HLQVEPHKDY ELVSALRAAA KGFNIEAEQV AGVPTETIYE 250 260 270 280 290 300 AVDICKNAQF GSLFFAMGVT MSRGKHRIID NAIQFVIDMN AYTKFVLTPM RGHYNVNGFN 310 320 330 340 350 360 QVSTWVTGYP YGVDFSRGYP RYNPGETASN DVLQRGDTDM MINVASDAGA HFPQKAVQHM 370 380 390 400 410 420 AKIPLVCIDP HETPSSVISN IVLPPAITGL EVSGTAYRMD GVPIELRKVI KAPEGMLSDA 430 EIMKMLIKKV DEMK

References

[1]

"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis." Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A. J. Bacteriol. 186:6956-6969(2004) [PubMed: 15466049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S2 / LL.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX950229 Genomic DNA. Translation: CAF31247.1.
RefSeq	NP_988811.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2762359.
GenomeReviews	Gene locus MMP1691 in contig BX950229_GR.
KEGG	mmp:MMP1691.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6LWL8.
OMA	NVVCPFC.
Enzyme and pathway databases
BRENDA	1.2.99.5. 20956.
Family and domain databases
InterPro	IPR016457. Formylmethanofuran_DH_bsu. [Graphical view]
PIRSF	PIRSF005646. FwdB. 1 hit.
TIGRFAMs	TIGR03129. one_C_dehyd_B. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FWDB_METMP

Accession

Primary (citable) accession number: Q6LWL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	November 3, 2009
This is version 30 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)