Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6LWL8 (FWDB_METMP) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tungsten-containing formylmethanofuran dehydrogenase 2 subunit B
EC=1.2.99.5
Alternative name(s):
Tungsten-containing formylmethanofuran dehydrogenase II subunit B
Gene names
Name:fwdB
Ordered Locus Names:MMP1691
OrganismMethanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]
Taxonomic identifier267377 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of CO2 and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile By similarity.

Catalytic activity

Formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor.

Cofactor

Tungsten By similarity.

Pathway

One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.

Subunit structure

This enzyme is composed of six subunits fwdA, fwdC, fwdD, fwdE, fwdF and fwdG By similarity.

Sequence similarities

Belongs to the fwdB family.

Ontologies

Keywords
   Biological processMethanogenesis
   Coding sequence diversitySelenocysteine
   LigandTungsten
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmethanogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionformylmethanofuran dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Tungsten-containing formylmethanofuran dehydrogenase 2 subunit B
PRO_0000318645

Amino acid modifications

Non-standard residue1201Selenocysteine Probable

Sequences

Sequence LengthMass (Da)Tools
Q6LWL8 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: F7CBD9D17D4F8C06

FASTA43448,323
        10         20         30         40         50         60 
MEVFKNVVCP FCGTLCDDIE VLVENNHVVG TRNACRIGNA KFMHFEGAIR HESPLMRENK 

        70         80         90        100        110        120 
KDDFKKVDYE TATEETARLL VEAKLPLIYG WSSAECHAQQ LGVLLAEKTK AIVDNTASVU 

       130        140        150        160        170        180 
HGPSLLAVQD VGYPVSTLGE TKNRADVVLF WGSNPMHAHP RHMSRYSVFP RGFFRQRGKQ 

       190        200        210        220        230        240 
DRQMIVVDPR KTDTAKLADI HLQVEPHKDY ELVSALRAAA KGFNIEAEQV AGVPTETIYE 

       250        260        270        280        290        300 
AVDICKNAQF GSLFFAMGVT MSRGKHRIID NAIQFVIDMN AYTKFVLTPM RGHYNVNGFN 

       310        320        330        340        350        360 
QVSTWVTGYP YGVDFSRGYP RYNPGETASN DVLQRGDTDM MINVASDAGA HFPQKAVQHM 

       370        380        390        400        410        420 
AKIPLVCIDP HETPSSVISN IVLPPAITGL EVSGTAYRMD GVPIELRKVI KAPEGMLSDA 

       430 
EIMKMLIKKV DEMK

« Hide

References

[1]"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis."
Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. expand/collapse author list , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.
J. Bacteriol. 186:6956-6969(2004) [PubMed: 15466049] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S2 / LL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX950229 Genomic DNA. Translation: CAF31247.1.
RefSeqNP_988811.1. NC_005791.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2762359.
GenomeReviewsGene locus MMP1691 in contig BX950229_GR.
KEGGmmp:MMP1691.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG538951.
OMAIPLVCID.
ProtClustDBCLSK2750612.

Family and domain databases

InterProIPR016457. Formylmethanofuran_DH_bsu.
IPR006656. Mopterin_OxRdtase.
[Graphical view]
KOK00201.
PANTHERPTHR11615:SF34. PTHR11615:SF34. 1 hit.
PfamPF00384. Molybdopterin. 1 hit.
[Graphical view]
PIRSFPIRSF005646. FwdB. 1 hit.
TIGRFAMsTIGR03129. One_C_dehyd_B. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFWDB_METMP
AccessionPrimary (citable) accession number: Q6LWL8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 16, 2011
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents