Reviewed, UniProtKB/Swiss-Prot Q6LVE5 (ASTD_PHOPR)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	PBPRA0291

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_0000262409
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	278	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LVE5-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0CF9CA7994567463	FASTA	485	51,848
	10 20 30 40 50 60 MTQWIAGNWL AGKGEAMNSL NPFSSEEIWQ GDAATAEQVE QAVSAAREAL TTWRKTDLSE 70 80 90 100 110 120 RQAVVEKFAE LVKEHSEHIA HTIAEETGKP LWETRTEAGA MVGKIAISLR AYHERTGEKQ 130 140 150 160 170 180 KDIAGTAAVL RHRPLGVMAV FGPYNFPGHL PNGHIVPALL SGNTVVFKPS ELTPKVAQET 190 200 210 220 230 240 MKLWEQAGLP KGVLNMVQGA RPTGEALAGS KGIDGLLFTG SANTGHILHR QYAGQPGKML 250 260 270 280 290 300 ALEMGGNNPM VISKSYGELD ATVYTIIQSA FISAGQRCTC ARRLYLPQGI EGDAILNRLV 310 320 330 340 350 360 EATAKIRIGG PFAEPQPFMG PQISERAADG IIAAQANLVS LGGEVLLEAI RGQGAIVSPA 370 380 390 400 410 420 IIEVSNVAEL PDEEYFGPLL QVVRYQDLPD AVELANDTRY GLSAGLVSTD DSEWQYFIDN 430 440 450 460 470 480 IRAGIVNRNR QLTGASGDAP FGGPGASGNL RPSAYYAADY CAYPMASMEG EQTELPAQLS PGIAL

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR378663 Genomic DNA. Translation: CAG18730.1.
RefSeq	YP_128532.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3123901.
GenomeReviews	Gene locus PBPRA0291 in contig CR354531_GR.
KEGG	ppr:PBPRA0291.
NMPDR	fig|298386.1.peg.2516.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6LVE5.
Enzyme and pathway databases
BioCyc	PPRO298386:PBPRA0291-MON.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_PHOPR

Accession

Primary (citable) accession number: Q6LVE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)