Q6LUX0 (PYRB_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	PBPRA0474

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113170

Sequences

	Sequence		Length	Mass (Da)
	Q6LUX0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A683F9DEA4BAE12C	FASTA	309	34,434
	10 20 30 40 50 60 MANSLFQKHI ISIPELNRSE LELIVETAGI LKAEPNPELL KNKVVASCFF EPSTRTRLSF 70 80 90 100 110 120 ETAVQRLGGT VIGFDNGGNT SLAKKGETLA DSVQVISSYV DAFVMRHPQE GAARLASEFS 130 140 150 160 170 180 NGVPIINGGD GANQHPTQTL LDLFSIFETQ GRLDNLNVAF VGDLKYGRTV HSLTQALSKF 190 200 210 220 230 240 NNINFFFVAP EILAMPDYIC EELDEAGINY SLHASMEEVI PELDVLYMTR VQKERFDESE 250 260 270 280 290 300 YAHMKAAYIL TADMLAEARD NMKILHPLPR IDEITVDVDK TKHAYYFQQA ENGVYAREAL LALVLNEQL

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SS9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR378664 Genomic DNA. Translation: CAG18905.1.
RefSeq	YP_128707.1. NC_006370.1.
3D structure databases
ProteinModelPortal	Q6LUX0.
SMR	Q6LUX0. Positions 2-309.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3124443.
GenomeReviews	Gene locus PBPRA0474 in contig CR354531_GR.
KEGG	ppr:PBPRA0474.
NMPDR	fig|298386.1.peg.2703.
PATRIC	22931626. VBIPhoPro109272_0552.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	FKQSFYG.
PhylomeDB	Q6LUX0.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	PPRO298386:PBPRA0474-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_PHOPR

Accession

Primary (citable) accession number: Q6LUX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program