Reviewed, UniProtKB/Swiss-Prot Q6LUW9 (OTCC_PHOPR)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	PBPRA0475

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000112980
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	274 – 277	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LUW9-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0AE76F7AE96CF9D5	FASTA	336	37,584
	10 20 30 40 50 60 MAFNLRNRNF LKLLDFTPRE IQHMLELAAE LKKAKYNGYE QPRLKGKNIA LIFEKASTRT 70 80 90 100 110 120 RCAFEVAAYD QGANVTYLGP SGSQIGYKES MKDTARVLGR MYDGIEYRGF GQEIVETLGA 130 140 150 160 170 180 HAGVPVWNGL TDEFHPTQIL ADFLTMQEHA RGKQLSEVTF AYLGDARNNM GNSLMVGAAK 190 200 210 220 230 240 MGMDIRLVAP KAFWPEEELV AQCREIAEET GAKITVTEDV QEGVEGCDFL YTDVWVSMGE 250 260 270 280 290 300 AKEAWAERIS LMMPYQVNMA MLKATGNPHV KFMHCLPAFH GEDTVVGKEL AQEYPELKDG 310 320 330 VEVTDEVVES KHSIVFDEAE NRLHTIKAIM VATLGQ

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR378664 Genomic DNA. Translation: CAG18906.1.
RefSeq	YP_128708.1.
3D structure databases
HSSP	HSSP built from PDB template 1AKM based on UniProtKB P04391.
SMR	Q6LUW9. Positions 7-336.
ModBase	Search...
Genome annotation databases
GeneID	3122547.
GenomeReviews	Gene locus PBPRA0475 in contig CR354531_GR.
KEGG	ppr:PBPRA0475.
NMPDR	fig|298386.1.peg.2704.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6LUW9.
OMA	NPNVKFM.
Enzyme and pathway databases
BioCyc	PPRO298386:PBPRA0475-MON.
BRENDA	2.1.3.3. 263915.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_PHOPR

Accession

Primary (citable) accession number: Q6LUW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)