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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (deoA)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00578; UER00638

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotation
Ordered Locus Names:PBPRA0631
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000590581 – 443Thymidine phosphorylaseAdd BLAST443

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA0631

Structurei

3D structure databases

ProteinModelPortaliQ6LUH3
SMRiQ6LUH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMW Bacteria
COG0213 LUCA
HOGENOMiHOG000047313
KOiK00758
OrthoDBiPOG091H02BC

Family and domain databases

Gene3Di3.40.1030.10, 2 hits
3.90.1170.30, 1 hit
HAMAPiMF_01628 Thymid_phosp, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR018090 Pyrmidine_PPas_bac/euk
IPR017872 Pyrmidine_PPase_CS
IPR000053 Thymidine/pyrmidine_PPase
IPR013465 Thymidine_Pase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02643 T_phosphoryl, 1 hit
TIGR02644 Y_phosphoryl, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LUH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLPQEIIRK KRDNVELTAD EINFFIQGIA KETMSEGQIA AFAMAIYFND
60 70 80 90 100
MTMDERVALT CAMRDSGMVI DWSHMNFDGP IVDKHSTGGV GDVTSLMLGP
110 120 130 140 150
MVAACGGFVP MISGRGLGHT GGTLDKLESI PGYNITPTND VFGQVTKDAG
160 170 180 190 200
VAIIGQTGDL APADKRVYAT RDVTATVDNI SLITASILSK KLAAGLGSLV
210 220 230 240 250
MDVKVGSGAF MPTYEASEDL AKSIVAVANG AGTKTTALLT DMNQVLASTA
260 270 280 290 300
GNALEVREAV QFLTGEYRNP RLFEVTMALC AEMLVNSGLA SDIEQAREQL
310 320 330 340 350
QAVLDNGKAA TCFGKMVAGL GGPVDFMENY DNYLEKAEIA KPVFAETTGY
360 370 380 390 400
AYAMDTRGLG MAVVGMGGGR RVASDSIDYA VGLSDMIRLG DEVNTDTALC
410 420 430 440
VIHARSEAQW QEAANAVRAN ITIADEKPAP TPDVYRRIRA EDI
Length:443
Mass (Da):47,120
Last modified:January 10, 2006 - v2
Checksum:i90A596E57D8ED929
GO

Sequence cautioni

The sequence CAG19052 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378664 Genomic DNA Translation: CAG19052.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiCAG19052; CAG19052; PBPRA0631
KEGGippr:PBPRA0631

Similar proteinsi

Entry informationi

Entry nameiTYPH_PHOPR
AccessioniPrimary (citable) accession number: Q6LUH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: May 23, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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