Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q6LU24 (PUR4_PHOPR)

Last modified February 9, 2010. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Phosphoribosylformylglycinamidine synthase
      Short name=FGAM synthase
      Short name=FGAMS
    EC=6.3.5.3
Alternative name(s):
    Formylglycinamide ribotide amidotransferase
      Short name=FGARAT
    Formylglycinamide ribotide synthetase
Gene names
Name: purL
Ordered Locus Names: PBPRA0788
OrganismPhotobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]
Taxonomic identifier74109 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Hide | Top

Protein attributes

Sequence length1322 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00419

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00419

Subunit structure

Monomer. HAMAP MF_00419

Subcellular location

Cytoplasm HAMAP MF_00419.

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Contains 1 glutamine amidotransferase type-1 domain.

Hide | Top

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

glutamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13221322Phosphoribosylformylglycinamidine synthase HAMAP MF_00419
PRO_0000264583

Regions

Domain1069 – 1322254Glutamine amidotransferase type-1
Nucleotide binding307 – 31812ATP Potential

Sites

Active site11621Nucleophile By similarity
Active site12871 By similarity
Active site12891 By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q6LU24-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B93E5AD4EB87759D

FASTA1,322144,157
        10         20         30         40         50         60 
MEILRGSPAL SEFRVNKLLE RCRELDLPVS GIYAEFMHFA DVSAPLNSDE QSKLASLLTY 

        70         80         90        100        110        120 
GPTIAEHEPT GTMLLVTPRP GTISPWSSKS TDIAQNCALG NVKRLERGTA YYVEVTADLT 

       130        140        150        160        170        180 
NAQLTDLKAL IHDRMMEVVF TDVDSAAALF TQAEPAPVQS VDILVGGRKA LEDANLKLGL 

       190        200        210        220        230        240 
ALAEDEIDYL VENFTMLGRN PNDIELMMFA QANSEHCRHK IFNADWTIDG VEQEKSLFKM 

       250        260        270        280        290        300 
IKNTYEKNHE HVLSAYKDNA AVMEGSEVGR FFPNPESRQY NYHQEAAHIL MKVETHNHPT 

       310        320        330        340        350        360 
AISPWPGAST GSGGEIRDEG ATGLGGKPKA GLVGFTVSNL RVPGFEQPWE TDFGKPGRIV 

       370        380        390        400        410        420 
NALEIMLEGP LGGAAFNNEF GRPNLLGYFR TYEEKVTSHN GEEIRGYHKP IMIAGGMGNI 

       430        440        450        460        470        480 
RADHVQKKEI PVGAKLIVLG GPAMNIGLGG GAASSMASGQ SAEDLDFASV QRENPEMERR 

       490        500        510        520        530        540 
CQEVIDRCWQ MGDANPIAFI HDVGAGGISN ALPELVDDGE RGGKFQLRNV PNDEPGMSPL 

       550        560        570        580        590        600 
EIWCNESQER YVMAVAPENL AVFEAICKRE RAPFAVVGEA TEERHLTLED EHFDNTPIDM 

       610        620        630        640        650        660 
PMDILLGKAP KMHRDAKTLK VEGQAIDRSG IELEAATQRV LRLPAVAEKT FLITIGDRSV 

       670        680        690        700        710        720 
TGLVARDQMV GPWQVPVANC AVTAASYDTY HGEAMSMGER TPVALLDFGA SARLAVGEAI 

       730        740        750        760        770        780 
TNIASADIGD MKRINLSANW MSPAGHPGED AGLYEAVKAV GEELCPALGL TIPVGKDSMS 

       790        800        810        820        830        840 
MKTKWEQDGE QKEVTSPLSL VITAFGRVED VRKTVTPQLR TDKGESSLIL IDLGCGQNRL 

       850        860        870        880        890        900 
GATALAQVYK QLGDKPADVD NPELLKGFFY AVQALVRDEK VLAYHDRGDG GLYVTLAEMA 

       910        920        930        940        950        960 
FAGHTGVEVD INTSESDACD DVLAMLFNEE LGAVLQVRTE DLDTVKSVLA EHGLTACSHV 

       970        980        990       1000       1010       1020 
IGTVVDEDVV RIWNGNDRVL EQSRTDLRTV WAETTYQMQA MRDNPAGALQ EFEAKKDNSD 

      1030       1040       1050       1060       1070       1080 
PGLSAQLTFD INEDVAAPFI AAPFITKAPK TGASVVNAPA INLGAKPQMA ILREQGVNSH 

      1090       1100       1110       1120       1130       1140 
VEMAAAFDRA GFEATDVHMS DILSGNVQLE GFNGLVACGG FSYGDVLGAG EGWAKSVLFN 

      1150       1160       1170       1180       1190       1200 
NIARDQFEAF FKRNDTFSLG VCNGCQMMSN LSELIPGSDL WPRFVRNESE RFEARFSLVE 

      1210       1220       1230       1240       1250       1260 
VQKSDSLFFN EMAGSRMPIA VSHGEGRVEV RNGEHLNAIE QSGTVALRYL DNFGNVTQNY 

      1270       1280       1290       1300       1310       1320 
PANPNGSPNG ITGLTTMDGR VTIMMPHPER VFRTVANSWH PDDWNENSPW MRMFRNARVN 


LG

« Hide

Hide | Top

References

[1]"Life at depth: Photobacterium profundum genome sequence and expression analysis."
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.
Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR378665 Genomic DNA. Translation: CAG19201.1.
RefSeqYP_129003.1.

3D structure databases

HSSPHSSP built from PDB template 1T3T based on UniProtKB P74881.
ModBaseSearch...

Genome annotation databases

GeneID3122744.
KEGGppr:PBPRA0788.
NMPDRfig|298386.1.peg.3014.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG335309.
OMAERGIAYY.
PhylomeDBQ6LU24.

Enzyme and pathway databases

BioCycPPRO298386:PBPRA0788-MONOMER.
BRENDA6.3.5.3. 263915.

Family and domain databases

HAMAPMF_00419. PurL_1.
[Tree]
InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR017926. GATASE_1.
IPR010073. PRibForGlyAmidine_synth.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
TIGRFAMsTIGR01735. FGAM_synt. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry namePUR4_PHOPR
AccessionPrimary (citable) accession number: Q6LU24
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: February 9, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents