Reviewed, UniProtKB/Swiss-Prot Q6LU17 (GLYA1_PHOPR)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase 1
      Short name=Serine methylase 1
      Short name=SHMT 1
    EC=2.1.2.1

Gene names

Name:	glyA1
Ordered Locus Names:	PBPRA0795

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine. HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Serine hydroxymethyltransferase 1 HAMAP MF_00051		PRO_0000113631
Amino acid modifications
	Modified residue	229	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LU17-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 81FE156B89785BD0	FASTA	416	45,190
	10 20 30 40 50 60 MLKRDMNIAD YDAELFAAIQ EETARQEEHI ELIASENYTS PRVMEAQGSQ LTNKYAEGYP 70 80 90 100 110 120 GKRYYGGCEF VDKAEQLAID RACQLFGAEY ANVQPHSGSQ ANNAVYMALL NPGDTVLGMS 130 140 150 160 170 180 LAHGGHLTHG SPVNFSGKLY NIIPYGIDET GQIDYEEMEA LALEHKPKMI IGGFSAYSQV 190 200 210 220 230 240 VDWKRMREIA DKVGAYFFVD MAHVAGLIAA GVYPNPVPHA HVVTTTTHKT LAGPRGGLIL 250 260 270 280 290 300 SNDGEALYKK LNSAVFPGGQ GGPLMHVIAA KAVAFKEAME PEFKVYQACV VENAKAMVGE 310 320 330 340 350 360 FLERGYKIVS GSTENHLFLV DLIDKGITGK EADAALGAAN ITVNKNSVPN DPRSPFVTSG 370 380 390 400 410 IRIGTPSITR RGFTVEDTKQ LAGWICDVLD NTDKPEVIEA TKAKVLEICK RLPVYA

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR378665 Genomic DNA. Translation: CAG19208.1.
RefSeq	YP_129010.1.
3D structure databases
SMR	Q6LU17. Positions 1-416.
ModBase	Search...
Genome annotation databases
GeneID	3123727.
GenomeReviews	Gene locus PBPRA0795 in contig CR354531_GR.
KEGG	ppr:PBPRA0795.
NMPDR	fig|298386.1.peg.3021.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6LU17.
OMA	DYEAVES.
Enzyme and pathway databases
BioCyc	PPRO298386:PBPRA0795-MON.
BRENDA	2.1.2.1. 263915.
Family and domain databases
HAMAP	MF_00051. [Tree]
InterPro	IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA1_PHOPR

Accession

Primary (citable) accession number: Q6LU17

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)