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Protein

Xanthine phosphoribosyltransferase

Gene

gpt

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts on guanine, xanthine and to a lesser extent hypoxanthine.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (gpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei695-phosphoribose 1-diphosphateUniRule annotation1
Metal bindingi89MagnesiumUniRule annotation1
Binding sitei92XanthineUniRule annotation1
Binding sitei135Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Alternative name(s):
Xanthine-guanine phosphoribosyltransferaseUniRule annotation
Short name:
XGPRTUniRule annotation
Gene namesi
Name:gptUniRule annotation
Ordered Locus Names:PBPRA0836
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001396781 – 152Xanthine phosphoribosyltransferaseAdd BLAST152

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA0836

Structurei

3D structure databases

ProteinModelPortaliQ6LTX6
SMRiQ6LTX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 385-phosphoribose 1-diphosphate bindingUniRule annotation2
Regioni92 – 965-phosphoribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DYA Bacteria
COG0503 LUCA
HOGENOMiHOG000226805
KOiK00769
OMAiFHRDCRA
OrthoDBiPOG091H03MJ

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01903 XGPRT, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023747 Xanthine_Guanine_PRibTrfase
PANTHERiPTHR39563 PTHR39563, 1 hit
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
PROSITEiView protein in PROSITE
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LTX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKFVITWD NMQMYTRQLA EKLLPADQWK GIIAVSRGGL VPAAILAREL
60 70 80 90 100
NIRHVDTVCI SSYDHDHQRE MKVLKQADGD GEGFIVIDDL VDTGGTAELI
110 120 130 140 150
RAMYPKAKFV TVCAKPAGKH FIDDYVVDIA QDTWIEQPWD MAVTFVDPIS

KK
Length:152
Mass (Da):17,109
Last modified:July 5, 2004 - v1
Checksum:i66CD40B1C2438750
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378665 Genomic DNA Translation: CAG19249.1
RefSeqiWP_011217586.1, NC_006370.1

Genome annotation databases

EnsemblBacteriaiCAG19249; CAG19249; PBPRA0836
KEGGippr:PBPRA0836

Similar proteinsi

Entry informationi

Entry nameiXGPT_PHOPR
AccessioniPrimary (citable) accession number: Q6LTX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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