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Q6LTV9

- NAPA1_PHOPR

UniProt

Q6LTV9 - NAPA1_PHOPR

Protein

Periplasmic nitrate reductase 1

Gene

napA1

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism.UniRule annotation

    Catalytic activityi

    Nitrite + acceptor = nitrate + reduced acceptor.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster.UniRule annotation
    Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi48 – 481Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi51 – 511Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi55 – 551Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi83 – 831Iron-sulfur (4Fe-4S)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. electron carrier activity Source: UniProtKB-HAMAP
    3. iron ion binding Source: UniProtKB-HAMAP
    4. molybdenum ion binding Source: InterPro
    5. nitrate reductase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP
    2. nitrate assimilation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Nitrate assimilation, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Periplasmic nitrate reductase 1UniRule annotation (EC:1.7.99.4UniRule annotation)
    Gene namesi
    Name:napA1UniRule annotation
    Ordered Locus Names:PBPRA0853
    OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
    Taxonomic identifieri74109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
    ProteomesiUP000000593: Chromosome 1

    Subcellular locationi

    Periplasm UniRule annotation

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Tat-type signalUniRule annotationAdd
    BLAST
    Chaini31 – 828798Periplasmic nitrate reductase 1PRO_0000045993Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

    Interactioni

    Subunit structurei

    Interacts with NapB.UniRule annotation

    Protein-protein interaction databases

    STRINGi298386.PBPRA0853.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LTV9.
    SMRiQ6LTV9. Positions 41-827.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 97574Fe-4S Mo/W bis-MGD-typeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.UniRule annotation
    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.UniRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0243.
    HOGENOMiHOG000031441.
    KOiK02567.
    OMAiEYRGKTM.
    OrthoDBiEOG6CVV7G.

    Family and domain databases

    HAMAPiMF_01630. Nitrate_reduct.
    InterProiIPR009010. Asp_de-COase-like_dom.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    IPR010051. Periplasm_NO3_reductase_lsu.
    IPR006311. TAT_signal.
    [Graphical view]
    PfamiPF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    [Graphical view]
    SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    TIGRFAMsiTIGR01706. NAPA. 1 hit.
    PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6LTV9-1 [UniParc]FASTAAdd to Basket

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    MKMTRRAFVK ANAAASAAAV AGITLPASAA NLIVSSDETK IKWDKAPCRF    50
    CGTGCSVLVG TQNGRVVATQ GDPEAPVNKG LNCIKGYFLS KIMYGKDRLQ 100
    TPMLRMKNGE YNKEGDFAPV SWDQAFDVMA EKFKKALKEK GPTSVGMFGS 150
    GQWTVMEGYA ASKMMKAGFR SNNIDPNARH CMASAVGGFM RTFGIDEPMG 200
    CYDDFEHADS FVLWGSNMAE MHPVLWTRIT DRRLSHPHVK VNVLSTYYHR 250
    SFELADNGMI FEPQTDLAIA NFIANYIIQN DAVNWDFVTK HTHFKRAETD 300
    IGYGLRDDNP LQMKAKHPNS GALHPMDFEQ YKASVAEYTV EKASQMSGVS 350
    EEKLIEMAKQ YADPKVKVMS LWTMGMNQHT RGVWMNSLVY NIHLLTGKIS 400
    QPGNSPFSLT GQPSACGTAR EVGTFSHRLP ADMVVANPKH RAIAEKIWKL 450
    PDGTIPAKPG YHAVQQDRML KDGKLNAYWV MCNNNMQAGP NINEERLPGY 500
    RNPENFIVCS DPYPTVTAQA SDLILPTAMW VEKEGAYGNA ERRTQAWYQQ 550
    VKSQGDSKSD LWQLMEFSKR FKIEEVWGED LLAQMPEYRG KTMYEVLFRN 600
    GQVDKFPLSE AQELNDDAKA QGFYLQKGLF EEYAAFGRGH GHDLAPYDVY 650
    HQVRGLRWPV VDGKETLWRF VEGSDPYVPE GEGFRFYGKP DGKANIIFAP 700
    FEPAPEEPDQ EYDMWLCTGR VLEHWHTGTM TRRVPELYKA VPDALCFIHP 750
    DDAQKRGLRR GDEVLLESRR GEVRCRVETR GRNRPPVGLV FVPFFDARVL 800
    VNKLILDATD PLSKQTDYKK CPIKITKV 828
    Length:828
    Mass (Da):93,366
    Last modified:July 5, 2004 - v1
    Checksum:i58C80D6AE7BC8A63
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378665 Genomic DNA. Translation: CAG19266.1.
    RefSeqiYP_129068.1. NC_006370.1.

    Genome annotation databases

    EnsemblBacteriaiCAG19266; CAG19266; PBPRA0853.
    GeneIDi3123080.
    KEGGippr:PBPRA0853.
    PATRICi22932429. VBIPhoPro109272_0936.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378665 Genomic DNA. Translation: CAG19266.1 .
    RefSeqi YP_129068.1. NC_006370.1.

    3D structure databases

    ProteinModelPortali Q6LTV9.
    SMRi Q6LTV9. Positions 41-827.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 298386.PBPRA0853.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG19266 ; CAG19266 ; PBPRA0853 .
    GeneIDi 3123080.
    KEGGi ppr:PBPRA0853.
    PATRICi 22932429. VBIPhoPro109272_0936.

    Phylogenomic databases

    eggNOGi COG0243.
    HOGENOMi HOG000031441.
    KOi K02567.
    OMAi EYRGKTM.
    OrthoDBi EOG6CVV7G.

    Family and domain databases

    HAMAPi MF_01630. Nitrate_reduct.
    InterProi IPR009010. Asp_de-COase-like_dom.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    IPR010051. Periplasm_NO3_reductase_lsu.
    IPR006311. TAT_signal.
    [Graphical view ]
    Pfami PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    [Graphical view ]
    SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    TIGRFAMsi TIGR01706. NAPA. 1 hit.
    PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS9.

    Entry informationi

    Entry nameiNAPA1_PHOPR
    AccessioniPrimary (citable) accession number: Q6LTV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3