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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei243ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:PBPRA0874
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196211 – 474Glutamate--tRNA ligaseAdd BLAST474

Proteomic databases

PRIDEiQ6LTT8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA0874

Structurei

3D structure databases

ProteinModelPortaliQ6LTT8
SMRiQ6LTT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi240 – 244"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LTT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKTRFAPS PTGFLHVGGA RTALYSWLFA KHMGGEFVLR IEDTDLERST
60 70 80 90 100
QEAIDAILEG MEWLGMDWDE GPYYQTKRFD RYNQLVDQLL AEDKAYKCYC
110 120 130 140 150
PKALLDELRE EQMAAGVKPR YDANHPKIVA ANAAATEDSA FCIRFRNPKE
160 170 180 190 200
GTVVFEDKVR GRIEIANSEL DDLIIRRTDG SPTYNFCVVI DDWDMGITQV
210 220 230 240 250
VRGEDHINNT PRQINIYKAI GAPVPEFAHC AMILGDDGAK LSKRHGAVSV
260 270 280 290 300
MQYRDEGYLP QALLNYLIRL GWSHGDQEIF SMEEMINLFS LESISKSASA
310 320 330 340 350
FNTDKLLWLN NHYIKTAEPE YVAKYLQWHL EQKEIDTANG PKITDVIGLV
360 370 380 390 400
GERCNTLIEL ADQSRYFYQD FSEFEAGAAK KHLRPVAKDA LALVLSKVEA
410 420 430 440 450
LEEWNTENLH VVIADTCTEL EVGMGKVGMP LRVAVTGQGQ SPSVDATMML
460 470
IGKERVVNRI TMALAFIAER EANA
Length:474
Mass (Da):53,348
Last modified:July 5, 2004 - v1
Checksum:i0706EA6F7223F604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378665 Genomic DNA Translation: CAG19287.1
RefSeqiWP_011217624.1, NC_006370.1

Genome annotation databases

EnsemblBacteriaiCAG19287; CAG19287; PBPRA0874
KEGGippr:PBPRA0874

Similar proteinsi

Entry informationi

Entry nameiSYE_PHOPR
AccessioniPrimary (citable) accession number: Q6LTT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health