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Protein

Fatty acid oxidation complex subunit alpha

Gene

fadJ

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.UniRule annotation

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.UniRule annotation
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.UniRule annotation
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei125Important for catalytic activityUniRule annotation1
Sitei147Important for catalytic activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase, Multifunctional enzyme, Oxidoreductase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid oxidation complex subunit alphaUniRule annotation
Including the following 2 domains:
Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimeraseUniRule annotation (EC:4.2.1.17UniRule annotation, EC:5.1.2.3UniRule annotation)
3-hydroxyacyl-CoA dehydrogenaseUniRule annotation (EC:1.1.1.35UniRule annotation)
Gene namesi
Name:fadJUniRule annotation
Ordered Locus Names:PBPRA0962
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001093021 – 715Fatty acid oxidation complex subunit alphaAdd BLAST715

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA0962

Structurei

3D structure databases

ProteinModelPortaliQ6LTK3
SMRiQ6LTK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 197Enoyl-CoA hydrataseUniRule annotationAdd BLAST190
Regioni313 – 7153-hydroxyacyl-CoA dehydrogenaseUniRule annotationAdd BLAST403

Sequence similaritiesi

In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.UniRule annotation
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DYT Bacteria
COG1024 LUCA
COG1250 LUCA
HOGENOMiHOG000261346
KOiK01782
OMAiPFRYMDT
OrthoDBiPOG091H00UW

Family and domain databases

HAMAPiMF_01617 FadJ, 1 hit
InterProiView protein in InterPro
IPR006180 3-OHacyl-CoA_DH_CS
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR029045 ClpP/crotonase-like_dom_sf
IPR001753 Enoyl-CoA_hydra/iso
IPR012802 FadJ
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PF00378 ECH_1, 1 hit
SUPFAMiSSF48179 SSF48179, 2 hits
SSF51735 SSF51735, 1 hit
SSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR02440 FadJ, 1 hit
PROSITEiView protein in PROSITE
PS00067 3HCDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LTK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQHESANSQ PSAFSLTFGD NGVAWLKIDV PNERMNTLQS AFVDQVTDVL
60 70 80 90 100
AQLKDKKDIK GMVVYSGKPD NFIAGADIRM LAACQTADEA QQLAAKGQEL
110 120 130 140 150
FGQLEALPFH VVAAIHGPCL GGGLELALAC HSRVCSDDDK TRLGLPEVQL
160 170 180 190 200
GLLPGSGGTQ RLPRLIGVAN ALDMILTGKQ LRAKKAKNLG LVEEAVPLSI
210 220 230 240 250
LLDIAEKQAL KGKPKRKGSF QEWAMGGNAL GRSVVFDQAA KKTHEKTRGN
260 270 280 290 300
YPAADAILDV IKYGLQHGMK KGLDQEAKRF GELVMTSESA ALRSIFFATT
310 320 330 340 350
AMKKESGSDA LPATIKKVGV LGGGLMGGGI SHVTATKAGY PVRIKDISND
360 370 380 390 400
GIKNALVYNF KLLDKQRKRR IISKAELQNK MFSITGGTTF TGFTNVDVVI
410 420 430 440 450
EAVFEDINLK HQMVKDIEQQ TSDYTIFASN TSSLPIHQIA AAAERPENVV
460 470 480 490 500
GLHYFSPVEK MPLVEVIPHQ GTENGSATSE QTIATVVALA KKQGKTPIVV
510 520 530 540 550
ADKAGFYVNR ILAPYMNEAA AVLLSGEPIE HIDRSLLDFG FPVGPITLLD
560 570 580 590 600
EVGVDIGAKI SPILLAELGE RFKAPDVFDL LLSDDRKGRK SGKGFYLYNT
610 620 630 640 650
KKKEVDKSVY KLLSLEPEQK AAGQDIALRC TLMMLNEAAR CLDEGVIKSA
660 670 680 690 700
RDGDIGAIFG IGFPPFLGGP FRYMDTLGAK RVVEMLKDHT DKYGGRFTPC
710
DKLVAMANEE QSFYS
Length:715
Mass (Da):77,342
Last modified:July 5, 2004 - v1
Checksum:iBEDB6D9C220C07A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378666 Genomic DNA Translation: CAG19373.1
RefSeqiWP_011217707.1, NC_006370.1

Genome annotation databases

EnsemblBacteriaiCAG19373; CAG19373; PBPRA0962
KEGGippr:PBPRA0962

Similar proteinsi

Entry informationi

Entry nameiFADJ_PHOPR
AccessioniPrimary (citable) accession number: Q6LTK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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