Q6LS46 (Q6LS46_PHOPR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
EC=6.3.2.6 HAMAP MF_00137

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137
Ordered Locus Names:	PBPRA1469

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137 SAAS SAAS001636
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137 SAAS SAAS001636
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137 RuleBase RU004193

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137 SAAS SAAS001636
Ligand	ATP-binding HAMAP MF_00137 SAAS SAAS001636 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 SAAS SAAS001636
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6LS46 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7D4664C0DAE26B69	FASTA	367	41,499
	10 20 30 40 50 60 MSLADQVLAV NDDLPIRTDK PVHSGKVRSV YWLTEADSRR LIEEKGYNVA PDAPLAIMVI 70 80 90 100 110 120 SDRISAFDCI WHGEGGMKGV PGKGAALNAI SNHWFKLFRD NDLAESHILD IPHPFIWIVQ 130 140 150 160 170 180 KAKPVMIEAI CRQYITGSMW RSYSKGERDF CGIEVPEGLN KDQKLPELLI TPSTKGILEG 190 200 210 220 230 240 IPGVPAVDDV NITRKNIEEN FEAFNFRNTD DINHYEKLLQ EGFDVISSEL EKLDQIFVDT 250 260 270 280 290 300 KFEFGYVTDA SGKEKLIYMD EVGTPDSSRI WDAAAYRDGK IVENSKEDFR QLLLNHFPDP 310 320 330 340 350 360 DILLNKDRME ERSALARDNA LPEEVLMQVS KIYTDIAEKI TGKKIVLSKN PKAEITAILR DQYGLVD

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR378667 Genomic DNA. Translation: CAG19880.1.
RefSeq	YP_129682.1. NC_006370.1.
3D structure databases
HSSP	HSSP built from PDB template 1A48 based on UniProtKB P27616.
ProteinModelPortal	Q6LS46.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3123208.
GenomeReviews	Gene locus PBPRA1469 in contig CR354531_GR.
KEGG	ppr:PBPRA1469.
NMPDR	fig|298386.1.peg.3722.
PATRIC	22933769. VBIPhoPro109272_1599.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG555040.
OMA	SSRIWDG.
PhylomeDB	Q6LS46.
ProtClustDB	PRK13960.
Enzyme and pathway databases
BioCyc	PPRO298386:PBPRA1469-MONOMER.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR014106. PurC_vibrio. IPR001636. SAICAR_synth. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02735. PurC_vibrio. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q6LS46_PHOPR

Accession

Primary (citable) accession number: Q6LS46

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)