Reviewed,
UniProtKB/Swiss-Prot Q6LRI5 (TPMT_PHOPR)
Last modified
February 9, 2010.
Version 39.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Thiopurine S-methyltransferase EC=2.1.1.67 Alternative name(s): Thiopurine methyltransferase | ||||
| Gene names |
| ||||
| Organism | Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 74109 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium |
Protein attributes
| Sequence length | 213 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00812. |
| Sequence similarities | Belongs to the methyltransferase superfamily. TPMT family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | thiopurine S-methyltransferase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 213 | 213 | Thiopurine S-methyltransferase HAMAP MF_00812 | PRO_0000220125 | |||||
Sites | |||||||||
| Binding site | 10 | 1 | S-adenosyl-L-methionine By similarity | ||||||
| Binding site | 45 | 1 | S-adenosyl-L-methionine; via carbonyl oxygen By similarity | ||||||
| Binding site | 66 | 1 | S-adenosyl-L-methionine By similarity | ||||||
| Binding site | 120 | 1 | S-adenosyl-L-methionine By similarity | ||||||
Sequences
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References
| [1] | "Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR378668 Genomic DNA. Translation: CAG20091.1. |
| RefSeq | YP_129893.1. |
3D structure databases | |
| SMR | Q6LRI5. Positions 1-211. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3124599. |
| KEGG | ppr:PBPRA1684. |
| NMPDR | fig|298386.1.peg.3943. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG444929. |
| OMA | TSIGHES. |
Enzyme and pathway databases | |
| BioCyc | PPRO298386:PBPRA1684-MONOMER. |
| BRENDA | 2.1.1.67. 263915. |
Family and domain databases | |
| HAMAP | MF_00812. Thiopur_methtran. [Tree] |
| InterPro | IPR008854. Thiopurine_S-MeTrfase. IPR016822. Thiopurine_S-MeTrfase_sub. [Graphical view] |
| Pfam | PF05724. TPMT. 1 hit. [Graphical view] |
| PIRSF | PIRSF023956. Thiopurine_S-methyltransferase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | TPMT_PHOPR | ||||||||
| Accession | Primary (citable) accession number: Q6LRI5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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