Reviewed, UniProtKB/Swiss-Prot Q6LRA6 (PNCB_PHOPR)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	PBPRA1763

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_0000205836

Sequences

	Sequence		Length	Mass (Da)
	Q6LRA6-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 37442FB0D3051F8E	FASTA	405	46,103
	10 20 30 40 50 60 MNHTKLIGII DSLLDTDAYK LHMQQAIYHQ YPHVEAVAEF HCRSKEDLRP YAKAIQAQIQ 70 80 90 100 110 120 HISTLSFAQE ELDYLASLSF FKKDYLTYLK DFSLNSEQVT VDGSGDQLSI KIKGKWIDII 130 140 150 160 170 180 LWEVPLLAII CEIRSSICYP HSTADDAIAQ LKTKIERFYL NAKTVDSATQ TATDLSQFDL 190 200 210 220 230 240 IDFGSRRRFS KDVHHKVVDY LAANVPEFKG TSNYHLARTR NLTPFGTQAH EWFQAHQQLT 250 260 270 280 290 300 GELADSQQLA LNRWLQEYPD SLGIALTDCI NTDAFLRDFN SELSERFVGL RHDSGDPITW 310 320 330 340 350 360 GEKAIKHYES LDIDLRTKSL IFSDSLTLDK ALNIYKHFAS RINVSFGIGT QLTCDLPGVE 370 380 390 400 TLNVVLKLTQ CEGRPVAKIS DEPGKIMCRD EDYLTQLRQA FKIAN

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR378668 Genomic DNA. Translation: CAG20170.1.
RefSeq	YP_129972.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3124035.
GenomeReviews	Gene locus PBPRA1763 in contig CR354531_GR.
KEGG	ppr:PBPRA1763.
NMPDR	fig|298386.1.peg.4028.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6LRA6.
OMA	ALTDTFG.
Enzyme and pathway databases
BioCyc	PPRO298386:PBPRA1763-MON.
BRENDA	2.4.2.11. 263915.
Family and domain databases
HAMAP	MF_00570. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_PHOPR

Accession

Primary (citable) accession number: Q6LRA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)