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Q6LRA6

- PNCB_PHOPR

UniProt

Q6LRA6 - PNCB_PHOPR

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Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, PBPRA1763
Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:PBPRA1763
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Nicotinate phosphoribosyltransferaseUniRule annotation
PRO_0000205836Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA1763.

Structurei

3D structure databases

ProteinModelPortaliQ6LRA6.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LRA6-1 [UniParc]FASTAAdd to Basket

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MNHTKLIGII DSLLDTDAYK LHMQQAIYHQ YPHVEAVAEF HCRSKEDLRP    50
YAKAIQAQIQ HISTLSFAQE ELDYLASLSF FKKDYLTYLK DFSLNSEQVT 100
VDGSGDQLSI KIKGKWIDII LWEVPLLAII CEIRSSICYP HSTADDAIAQ 150
LKTKIERFYL NAKTVDSATQ TATDLSQFDL IDFGSRRRFS KDVHHKVVDY 200
LAANVPEFKG TSNYHLARTR NLTPFGTQAH EWFQAHQQLT GELADSQQLA 250
LNRWLQEYPD SLGIALTDCI NTDAFLRDFN SELSERFVGL RHDSGDPITW 300
GEKAIKHYES LDIDLRTKSL IFSDSLTLDK ALNIYKHFAS RINVSFGIGT 350
QLTCDLPGVE TLNVVLKLTQ CEGRPVAKIS DEPGKIMCRD EDYLTQLRQA 400
FKIAN 405
Length:405
Mass (Da):46,103
Last modified:July 5, 2004 - v1
Checksum:i37442FB0D3051F8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378668 Genomic DNA. Translation: CAG20170.1.
RefSeqiYP_129972.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG20170; CAG20170; PBPRA1763.
GeneIDi3124035.
KEGGippr:PBPRA1763.
PATRICi22934415. VBIPhoPro109272_1918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378668 Genomic DNA. Translation: CAG20170.1 .
RefSeqi YP_129972.1. NC_006370.1.

3D structure databases

ProteinModelPortali Q6LRA6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA1763.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG20170 ; CAG20170 ; PBPRA1763 .
GeneIDi 3124035.
KEGGi ppr:PBPRA1763.
PATRICi 22934415. VBIPhoPro109272_1918.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 2 hits.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiPNCB_PHOPR
AccessioniPrimary (citable) accession number: Q6LRA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3
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