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Q6LRA6 (PNCB_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:PBPRA1763
OrganismPhotobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]
Taxonomic identifier74109 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_0000205836

Sequences

Sequence LengthMass (Da)Tools
Q6LRA6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 37442FB0D3051F8E

FASTA40546,103
        10         20         30         40         50         60 
MNHTKLIGII DSLLDTDAYK LHMQQAIYHQ YPHVEAVAEF HCRSKEDLRP YAKAIQAQIQ 

        70         80         90        100        110        120 
HISTLSFAQE ELDYLASLSF FKKDYLTYLK DFSLNSEQVT VDGSGDQLSI KIKGKWIDII 

       130        140        150        160        170        180 
LWEVPLLAII CEIRSSICYP HSTADDAIAQ LKTKIERFYL NAKTVDSATQ TATDLSQFDL 

       190        200        210        220        230        240 
IDFGSRRRFS KDVHHKVVDY LAANVPEFKG TSNYHLARTR NLTPFGTQAH EWFQAHQQLT 

       250        260        270        280        290        300 
GELADSQQLA LNRWLQEYPD SLGIALTDCI NTDAFLRDFN SELSERFVGL RHDSGDPITW 

       310        320        330        340        350        360 
GEKAIKHYES LDIDLRTKSL IFSDSLTLDK ALNIYKHFAS RINVSFGIGT QLTCDLPGVE 

       370        380        390        400 
TLNVVLKLTQ CEGRPVAKIS DEPGKIMCRD EDYLTQLRQA FKIAN 

« Hide

References

[1]"Life at depth: Photobacterium profundum genome sequence and expression analysis."
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.
Science 307:1459-1461(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR378668 Genomic DNA. Translation: CAG20170.1.
RefSeqYP_129972.1. NC_006370.1.

3D structure databases

ProteinModelPortalQ6LRA6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING298386.PBPRA1763.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG20170; CAG20170; PBPRA1763.
GeneID3124035.
KEGGppr:PBPRA1763.
PATRIC22934415. VBIPhoPro109272_1918.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284928.
KOK00763.
OMAQAVFHRY.
OrthoDBEOG6X10XB.

Enzyme and pathway databases

UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 2 hits.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_PHOPR
AccessionPrimary (citable) accession number: Q6LRA6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways