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Q6LRA0

- RLMKL_PHOPR

UniProt

Q6LRA0 - RLMKL_PHOPR

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Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene

rlmL

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

GO - Molecular functioni

  1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
Including the following 2 domains:
23S rRNA m2G2445 methyltransferaseUniRule annotation (EC:2.1.1.173UniRule annotation)
Alternative name(s):
rRNA (guanine-N(2)-)-methyltransferase RlmLUniRule annotation
23S rRNA m7G2069 methyltransferaseUniRule annotation (EC:2.1.1.264UniRule annotation)
Alternative name(s):
rRNA (guanine-N(7)-)-methyltransferase RlmKUniRule annotation
Gene namesi
Name:rlmLUniRule annotation
Ordered Locus Names:PBPRA1769
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712Ribosomal RNA large subunit methyltransferase K/LPRO_0000366780Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA1769.

Structurei

3D structure databases

ProteinModelPortaliQ6LRA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 154112THUMPUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmKL family.UniRule annotation
Contains 1 THUMP domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0116.
HOGENOMiHOG000218371.
KOiK12297.
OMAiNKRGFKM.
OrthoDBiEOG6HJ238.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL.
InterProiIPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LRA0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQYLAITSR GLENLLAEEL EQLGAQSIQV VHAGVRFKAD QSTAYRCCLW
60 70 80 90 100
TRISSRIIQV LSEFTVRDDM DLYLGAAAIN WTEYFSNATR IVVDFNGTNR
110 120 130 140 150
EIRNSQYGAM KVKDAIVDRF TKADLRRPNI DREQPDLRIH MRLSGEKGVL
160 170 180 190 200
GLDMAGSGLH QRGYRTEAGR APLRETHAAA LVLKSGWTPG QPLLDPMCGS
210 220 230 240 250
GTLLIEAAMM AADIAPGLKR KRWGFESIKD FDKDAWLEIH AEASVKARRG
260 270 280 290 300
PAKVQTKFFG FELEHRILAI ARDNAGRAGV KELINFQQGD ATELKAPEGF
310 320 330 340 350
DAGIVICNPP YGERLGTTPE LISLYTELGN RLKLAFAGSS ASIYSGSNEL
360 370 380 390 400
LSCLRMRADK QFKLPNGALD CVLKTYLITA GSVKKEEGEA EGHVEQENVA
410 420 430 440 450
PDFANRLKKN ITKLNKWAKK EGIDCYRIYD ADLPNYNAAI DKYNDYLIIQ
460 470 480 490 500
EYAAPKTVPE EIARRRIMDV LRATIEVTGV QTDKVILKVR ERQKGKNQYQ
510 520 530 540 550
KLSNAERHII VNEYGVDLKV NLYDYLDTGL FLDHRITRKM LGDMAKGKDF
560 570 580 590 600
LNLFAYTGSA SVHAACGGAK STTTIDMSNT YLGWAQENME LNNQVGDQHE
610 620 630 640 650
FIQADCLQWL QEVDDTFDLI FIDPPTFSNS KRMKQTFDIQ RDHIMLMENL
660 670 680 690 700
KRMLRTDGKI VFSNNKRQFK MDLEKLNELG LDAKNISDKT LPMDFAKNKH
710
IHNSWIITHK ED
Length:712
Mass (Da):80,413
Last modified:July 5, 2004 - v1
Checksum:iB36C85C6AFE572C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378668 Genomic DNA. Translation: CAG20176.1.
RefSeqiYP_129978.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG20176; CAG20176; PBPRA1769.
GeneIDi3123889.
KEGGippr:PBPRA1769.
PATRICi22934429. VBIPhoPro109272_1925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378668 Genomic DNA. Translation: CAG20176.1 .
RefSeqi YP_129978.1. NC_006370.1.

3D structure databases

ProteinModelPortali Q6LRA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA1769.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG20176 ; CAG20176 ; PBPRA1769 .
GeneIDi 3123889.
KEGGi ppr:PBPRA1769.
PATRICi 22934429. VBIPhoPro109272_1925.

Phylogenomic databases

eggNOGi COG0116.
HOGENOMi HOG000218371.
KOi K12297.
OMAi NKRGFKM.
OrthoDBi EOG6HJ238.

Family and domain databases

Gene3Di 3.40.50.150. 3 hits.
HAMAPi MF_01858. 23SrRNA_methyltr_KL.
InterProi IPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view ]
Pfami PF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view ]
PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTi SM00981. THUMP. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
PROSITEi PS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiRLMKL_PHOPR
AccessioniPrimary (citable) accession number: Q6LRA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3