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Q6LRA0

- RLMKL_PHOPR

UniProt

Q6LRA0 - RLMKL_PHOPR

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Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene
rlmL, PBPRA1769
Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

GO - Molecular functioni

  1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase K/L
Including the following 2 domains:
23S rRNA m2G2445 methyltransferase (EC:2.1.1.173)
Alternative name(s):
rRNA (guanine-N(2)-)-methyltransferase RlmL
23S rRNA m7G2069 methyltransferase (EC:2.1.1.264)
Alternative name(s):
rRNA (guanine-N(7)-)-methyltransferase RlmK
Gene namesi
Name:rlmL
Ordered Locus Names:PBPRA1769
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712Ribosomal RNA large subunit methyltransferase K/LUniRule annotationPRO_0000366780Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA1769.

Structurei

3D structure databases

ProteinModelPortaliQ6LRA0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 154112THUMPAdd
BLAST

Sequence similaritiesi

Contains 1 THUMP domain.

Phylogenomic databases

eggNOGiCOG0116.
HOGENOMiHOG000218371.
KOiK12297.
OMAiNKRGFKM.
OrthoDBiEOG6HJ238.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL.
InterProiIPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LRA0-1 [UniParc]FASTAAdd to Basket

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MNQYLAITSR GLENLLAEEL EQLGAQSIQV VHAGVRFKAD QSTAYRCCLW    50
TRISSRIIQV LSEFTVRDDM DLYLGAAAIN WTEYFSNATR IVVDFNGTNR 100
EIRNSQYGAM KVKDAIVDRF TKADLRRPNI DREQPDLRIH MRLSGEKGVL 150
GLDMAGSGLH QRGYRTEAGR APLRETHAAA LVLKSGWTPG QPLLDPMCGS 200
GTLLIEAAMM AADIAPGLKR KRWGFESIKD FDKDAWLEIH AEASVKARRG 250
PAKVQTKFFG FELEHRILAI ARDNAGRAGV KELINFQQGD ATELKAPEGF 300
DAGIVICNPP YGERLGTTPE LISLYTELGN RLKLAFAGSS ASIYSGSNEL 350
LSCLRMRADK QFKLPNGALD CVLKTYLITA GSVKKEEGEA EGHVEQENVA 400
PDFANRLKKN ITKLNKWAKK EGIDCYRIYD ADLPNYNAAI DKYNDYLIIQ 450
EYAAPKTVPE EIARRRIMDV LRATIEVTGV QTDKVILKVR ERQKGKNQYQ 500
KLSNAERHII VNEYGVDLKV NLYDYLDTGL FLDHRITRKM LGDMAKGKDF 550
LNLFAYTGSA SVHAACGGAK STTTIDMSNT YLGWAQENME LNNQVGDQHE 600
FIQADCLQWL QEVDDTFDLI FIDPPTFSNS KRMKQTFDIQ RDHIMLMENL 650
KRMLRTDGKI VFSNNKRQFK MDLEKLNELG LDAKNISDKT LPMDFAKNKH 700
IHNSWIITHK ED 712
Length:712
Mass (Da):80,413
Last modified:July 5, 2004 - v1
Checksum:iB36C85C6AFE572C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378668 Genomic DNA. Translation: CAG20176.1.
RefSeqiYP_129978.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG20176; CAG20176; PBPRA1769.
GeneIDi3123889.
KEGGippr:PBPRA1769.
PATRICi22934429. VBIPhoPro109272_1925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378668 Genomic DNA. Translation: CAG20176.1 .
RefSeqi YP_129978.1. NC_006370.1.

3D structure databases

ProteinModelPortali Q6LRA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA1769.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG20176 ; CAG20176 ; PBPRA1769 .
GeneIDi 3123889.
KEGGi ppr:PBPRA1769.
PATRICi 22934429. VBIPhoPro109272_1925.

Phylogenomic databases

eggNOGi COG0116.
HOGENOMi HOG000218371.
KOi K12297.
OMAi NKRGFKM.
OrthoDBi EOG6HJ238.

Family and domain databases

Gene3Di 3.40.50.150. 3 hits.
HAMAPi MF_01858. 23SrRNA_methyltr_KL.
InterProi IPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view ]
Pfami PF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view ]
PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTi SM00981. THUMP. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
PROSITEi PS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiRLMKL_PHOPR
AccessioniPrimary (citable) accession number: Q6LRA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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