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Q6LRA0

- RLMKL_PHOPR

UniProt

Q6LRA0 - RLMKL_PHOPR

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Protein
Ribosomal RNA large subunit methyltransferase K/L
Gene
rlmL, PBPRA1769
Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

GO - Molecular functioni

  1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA large subunit methyltransferase K/L
    Including the following 2 domains:
    23S rRNA m2G2445 methyltransferase (EC:2.1.1.173)
    Alternative name(s):
    rRNA (guanine-N(2)-)-methyltransferase RlmL
    23S rRNA m7G2069 methyltransferase (EC:2.1.1.264)
    Alternative name(s):
    rRNA (guanine-N(7)-)-methyltransferase RlmK
    Gene namesi
    Name:rlmL
    Ordered Locus Names:PBPRA1769
    OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
    Taxonomic identifieri74109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
    ProteomesiUP000000593: Chromosome 1

    Subcellular locationi

    Cytoplasm Reviewed prediction UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 712712Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
    PRO_0000366780Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi298386.PBPRA1769.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LRA0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 154112THUMP
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 THUMP domain.

    Phylogenomic databases

    eggNOGiCOG0116.
    HOGENOMiHOG000218371.
    KOiK12297.
    OMAiNKRGFKM.
    OrthoDBiEOG6HJ238.

    Family and domain databases

    Gene3Di3.40.50.150. 3 hits.
    HAMAPiMF_01858. 23SrRNA_methyltr_KL.
    InterProiIPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view]
    PfamiPF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    SMARTiSM00981. THUMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 3 hits.
    PROSITEiPS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6LRA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQYLAITSR GLENLLAEEL EQLGAQSIQV VHAGVRFKAD QSTAYRCCLW    50
    TRISSRIIQV LSEFTVRDDM DLYLGAAAIN WTEYFSNATR IVVDFNGTNR 100
    EIRNSQYGAM KVKDAIVDRF TKADLRRPNI DREQPDLRIH MRLSGEKGVL 150
    GLDMAGSGLH QRGYRTEAGR APLRETHAAA LVLKSGWTPG QPLLDPMCGS 200
    GTLLIEAAMM AADIAPGLKR KRWGFESIKD FDKDAWLEIH AEASVKARRG 250
    PAKVQTKFFG FELEHRILAI ARDNAGRAGV KELINFQQGD ATELKAPEGF 300
    DAGIVICNPP YGERLGTTPE LISLYTELGN RLKLAFAGSS ASIYSGSNEL 350
    LSCLRMRADK QFKLPNGALD CVLKTYLITA GSVKKEEGEA EGHVEQENVA 400
    PDFANRLKKN ITKLNKWAKK EGIDCYRIYD ADLPNYNAAI DKYNDYLIIQ 450
    EYAAPKTVPE EIARRRIMDV LRATIEVTGV QTDKVILKVR ERQKGKNQYQ 500
    KLSNAERHII VNEYGVDLKV NLYDYLDTGL FLDHRITRKM LGDMAKGKDF 550
    LNLFAYTGSA SVHAACGGAK STTTIDMSNT YLGWAQENME LNNQVGDQHE 600
    FIQADCLQWL QEVDDTFDLI FIDPPTFSNS KRMKQTFDIQ RDHIMLMENL 650
    KRMLRTDGKI VFSNNKRQFK MDLEKLNELG LDAKNISDKT LPMDFAKNKH 700
    IHNSWIITHK ED 712
    Length:712
    Mass (Da):80,413
    Last modified:July 5, 2004 - v1
    Checksum:iB36C85C6AFE572C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378668 Genomic DNA. Translation: CAG20176.1.
    RefSeqiYP_129978.1. NC_006370.1.

    Genome annotation databases

    EnsemblBacteriaiCAG20176; CAG20176; PBPRA1769.
    GeneIDi3123889.
    KEGGippr:PBPRA1769.
    PATRICi22934429. VBIPhoPro109272_1925.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378668 Genomic DNA. Translation: CAG20176.1 .
    RefSeqi YP_129978.1. NC_006370.1.

    3D structure databases

    ProteinModelPortali Q6LRA0.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 298386.PBPRA1769.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG20176 ; CAG20176 ; PBPRA1769 .
    GeneIDi 3123889.
    KEGGi ppr:PBPRA1769.
    PATRICi 22934429. VBIPhoPro109272_1925.

    Phylogenomic databases

    eggNOGi COG0116.
    HOGENOMi HOG000218371.
    KOi K12297.
    OMAi NKRGFKM.
    OrthoDBi EOG6HJ238.

    Family and domain databases

    Gene3Di 3.40.50.150. 3 hits.
    HAMAPi MF_01858. 23SrRNA_methyltr_KL.
    InterProi IPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view ]
    Pfami PF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    SMARTi SM00981. THUMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 3 hits.
    PROSITEi PS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS9.

    Entry informationi

    Entry nameiRLMKL_PHOPR
    AccessioniPrimary (citable) accession number: Q6LRA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 5, 2004
    Last modified: June 11, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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