ID   MAO11_PHOPR             Reviewed;         562 AA.
AC   Q6LQM6;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   16-JUN-2009, entry version 37.
DE   RecName: Full=NAD-dependent malic enzyme 1;
DE            Short=NAD-ME 1;
DE            EC=1.1.1.38;
GN   Name=sfcA1; OrderedLocusNames=PBPRA1997;
OS   Photobacterium profundum (Photobacterium sp. (strain SS9)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Photobacterium.
OX   NCBI_TaxID=74109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15746425; DOI=10.1126/science.1103341;
RA   Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N.,
RA   Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N.,
RA   Romualdi C., Bartlett D.H., Valle G.;
RT   "Life at depth: Photobacterium profundum genome sequence and
RT   expression analysis.";
RL   Science 307:1459-1461(2005).
CC   -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH.
CC   -!- COFACTOR: Divalent metal cations. Prefers magnesium or manganese
CC       (By similarity).
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
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DR   EMBL; CR378669; CAG20400.1; ALT_INIT; Genomic_DNA.
DR   GenomeReviews; CR354531_GR; PBPRA1997.
DR   KEGG; ppr:PBPRA1997; -.
DR   NMPDR; fig|298386.1.peg.4263; -.
DR   HOGENOM; Q6LQM6; -.
DR   BioCyc; PPRO298386:PBPRA1997-MON; -.
DR   BRENDA; 1.1.1.38; 263915.
DR   GO; GO:0016619; F:malate dehydrogenase (oxaloacetate-decarbox...; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01619; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N.
DR   InterPro; IPR012302; Malic_NAD_bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Metal-binding; NAD; Oxidoreductase.
FT   CHAIN         1    562       NAD-dependent malic enzyme 1.
FT                                /FTId=PRO_0000160221.
FT   ACT_SITE    101    101       Proton donor (By similarity).
FT   ACT_SITE    172    172       Proton acceptor (By similarity).
FT   METAL       243    243       Divalent metal cation (By similarity).
FT   METAL       244    244       Divalent metal cation (By similarity).
FT   METAL       267    267       Divalent metal cation (By similarity).
FT   BINDING     154    154       NAD (By similarity).
FT   BINDING     267    267       NAD (By similarity).
FT   BINDING     415    415       NAD (By similarity).
FT   SITE        267    267       Important for activity (By similarity).
SQ   SEQUENCE   562 AA;  62558 MW;  07347A2F21BAF062 CRC64;
     MNNDKRPLYI PYAGPALLET PLLNKGSAFS IEERMFFNLE GLLPEAIESI EEQTERAYQQ
     YQKFDKDMDK HIYLRNIQDT NETLFYRLVE NHITEMMPII YTPTVGAACE DFSNIYRRGR
     GLFISYPNRD RIEDMLNNAS RQNVKVIVVT DGERILGLGD QGIGGMGIPI GKLALYTACG
     GISPAYTLPV VLDVGTNNPQ RLSDPMYMGW RHTRISGQEY DNFVDEFIQA VKRRWPDALI
     QFEDFAQKNA MPLLERYKNK ICCFNDDIQG TAAVTVGSLL AACKAAKSKL SEQRISFLGA
     GSAGCGIAEA IIAQMVSEGI SEAQARSQVF MVDRWGLLID DMPNLLNFQQ ALVQKRDTVN
     EWDLADNNVS LLDVMRNAKP TVLIGVSGVP GLFSEDVIRE MHAHCKRPIV FPLSNPTSRV
     EATPADIINW TDGNALVATG SPFEPVVHNG KTYPIAQCNN SYIFPGIGLG ILAVNARRVT
     DEMLMASSRA LAECSPLAIN GHGALLPPLE DIQKVSRKIA FAVAKKAIEQ GKAPKNSDER
     ILDKIDANFW QSDYRNYKRT SF
//