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Q6LQJ3

- NAPA2_PHOPR

UniProt

Q6LQJ3 - NAPA2_PHOPR

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Protein

Periplasmic nitrate reductase 2

Gene

napA2

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism.UniRule annotation

Catalytic activityi

Nitrite + acceptor = nitrate + reduced acceptor.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster.UniRule annotation
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi51 – 511Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi55 – 551Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi83 – 831Iron-sulfur (4Fe-4S)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. electron carrier activity Source: UniProtKB-HAMAP
  3. iron ion binding Source: UniProtKB-HAMAP
  4. molybdenum ion binding Source: InterPro
  5. nitrate reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP
  2. nitrate assimilation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Nitrate assimilation, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic nitrate reductase 2UniRule annotation (EC:1.7.99.4UniRule annotation)
Gene namesi
Name:napA2UniRule annotation
Ordered Locus Names:PBPRA2030
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

Subcellular locationi

Periplasm UniRule annotation

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Tat-type signalUniRule annotationAdd
BLAST
Chaini32 – 830799Periplasmic nitrate reductase 2PRO_0000045994Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Interactioni

Subunit structurei

Interacts with NapB.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA2030.

Structurei

3D structure databases

ProteinModelPortaliQ6LQJ3.
SMRiQ6LQJ3. Positions 41-829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 97574Fe-4S Mo/W bis-MGD-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.UniRule annotation
Contains 1 4Fe-4S Mo/W bis-MGD-type domain.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0243.
HOGENOMiHOG000031441.
OrthoDBiEOG6CVV7G.

Family and domain databases

HAMAPiMF_01630. Nitrate_reduct.
InterProiIPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR010051. Periplasm_NO3_reductase_lsu.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR01706. NAPA. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6LQJ3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKVSRRKFIK AQAVASAAAA AGISIPISAS NVVTDSSLTK ITWEKAPCRF
60 70 80 90 100
CGTGCSVNVG TKEGKVVATH GDIKSPVNRG LNCVKGYFLS KIMYGKDRLT
110 120 130 140 150
QPLLRMTDGK FDKNGEFSPI SWDQAFDIMA EKWKKTLKEK GPEAIGMFGS
160 170 180 190 200
GQWTIYDGYA ASKLMKAGFR SNNLEPNARH CMASAVVGFI RTFGIDEPMG
210 220 230 240 250
CYDDIEAADA FVLWGSNMVE MHPILWTRVT DRRLSVPGVK VSVLSTFEHR
260 270 280 290 300
SFELADIPII FTPQSDLAIL NFIANYIITN DKVNKDFTSK HVNFRRGTTD
310 320 330 340 350
IGYGLRPEHP LQQAAKNPDS GDSTPMTFEE FKAFVSEYTV EKASEISGVK
360 370 380 390 400
PDKLIELAEL YANPETKVVS FWTMGFNQHT RGVWCNNLVY NIHLLTGKIS
410 420 430 440 450
TPGNSPFSLT GQPSACGTAR EVGTFAHRLP ADLVVTNPEH RKIAEKIWKL
460 470 480 490 500
PDGTIPGKVG AHAVLQSRML KDGKINAYWI QVNNNLQAGA NINEETLPGY
510 520 530 540 550
RNPDNFIVVS EAYPTVTSQA ADLVLPTAMW VEKEGGFGNA ERRTQLWHQM
560 570 580 590 600
VEAPGESKPD LWQLMEFSKR FKTDEVWPKE LLDSNPDYKG KTLFDVLFIN
610 620 630 640 650
GNVNKYPLDD LAEGTLNDES NYYGFYVHKG LFEEYAEFGR GHGHDLAPFD
660 670 680 690 700
MYHETRGLRW PVVDGKETLW RYREGSDPYV KEGAGFEFYG KPDGKAIIFA
710 720 730 740 750
LPYEPAAESP DEEYDMWLST GRVIEHWHSG SMTQRVPELY KAYPDAQVFM
760 770 780 790 800
HPDDAKSRGL RRGDAVKVMS RRGEIITRVE TRGRNKPPIG LVFVPWFDAS
810 820 830
QLINKVTLDA TDPLSKQTDF KKCAVKIVKA
Length:830
Mass (Da):92,868
Last modified:February 7, 2006 - v2
Checksum:i80887A70897D1EDD
GO

Sequence cautioni

The sequence CAG20433.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378669 Genomic DNA. Translation: CAG20433.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiCAG20433; CAG20433; PBPRA2030.
PATRICi22934984. VBIPhoPro109272_2201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378669 Genomic DNA. Translation: CAG20433.1 . Different initiation.

3D structure databases

ProteinModelPortali Q6LQJ3.
SMRi Q6LQJ3. Positions 41-829.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA2030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG20433 ; CAG20433 ; PBPRA2030 .
PATRICi 22934984. VBIPhoPro109272_2201.

Phylogenomic databases

eggNOGi COG0243.
HOGENOMi HOG000031441.
OrthoDBi EOG6CVV7G.

Family and domain databases

HAMAPi MF_01630. Nitrate_reduct.
InterProi IPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR010051. Periplasm_NO3_reductase_lsu.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view ]
Pfami PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view ]
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
TIGRFAMsi TIGR01706. NAPA. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiNAPA2_PHOPR
AccessioniPrimary (citable) accession number: Q6LQJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3