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Q6LPQ4 (THIM_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:PBPRA2337
OrganismPhotobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]
Taxonomic identifier74109 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000336563

Sites

Binding site511Substrate; via amide nitrogen By similarity
Binding site1271ATP By similarity
Binding site1731ATP By similarity
Binding site2001Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LPQ4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: DE775759A1A10B5D

FASTA27428,815
        10         20         30         40         50         60 
MKKCDLDYTQ SICDALNTLR QQKPLVVNIT NYVVMNNTAN ALLAIGASPI MAHSQEEMAE 

        70         80         90        100        110        120 
MMSFAGSLVI NIGTLDSVWI PRMIYAVEQA NANNKPVILD PVGCGASALR TNTARQIVAL 

       130        140        150        160        170        180 
AEQLTIRGNA SEIIALAGEQ AQSKGVDALD SSDKAIHAAH HLATQNNCSV VISGATDYIV 

       190        200        210        220        230        240 
TTTATIALNN GHEMMPYVTG MGCSHTALTG AFAAIGEPTG LAATAVLGIA GEIAARDAAG 

       250        260        270 
PGSLQVNLLD TLYHLDEAVL REYIRINLVE EGCH 

« Hide

References

[1]"Life at depth: Photobacterium profundum genome sequence and expression analysis."
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.
Science 307:1459-1461(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR378670 Genomic DNA. Translation: CAG20722.1.
RefSeqYP_130524.1. NC_006370.1.

3D structure databases

ProteinModelPortalQ6LPQ4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING298386.PBPRA2337.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG20722; CAG20722; PBPRA2337.
GeneID3124385.
KEGGppr:PBPRA2337.
PATRIC22935646. VBIPhoPro109272_2516.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.
OrthoDBEOG628F8M.

Enzyme and pathway databases

UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_PHOPR
AccessionPrimary (citable) accession number: Q6LPQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways