Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi379 – 386ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:PBPRA2385
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 86HelicalUniRule annotationAdd BLAST21
Transmembranei143 – 165HelicalUniRule annotationAdd BLAST23
Transmembranei170 – 189HelicalUniRule annotationAdd BLAST20
Transmembranei252 – 272HelicalUniRule annotationAdd BLAST21
Transmembranei278 – 298HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716361 – 585Lipid A export ATP-binding/permease protein MsbAAdd BLAST585

Proteomic databases

PRIDEiQ6LPK6.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA2385.

Structurei

3D structure databases

ProteinModelPortaliQ6LPK6.
SMRiQ6LPK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 313ABC transmembrane type-1UniRule annotationAdd BLAST287
Domaini345 – 581ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OrthoDBiPOG091H00DB.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LPK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSTEQSTL DTYKRLWPYI SFYKAGLSVA VVALIINALG DTLMLSMIKP
60 70 80 90 100
LLDESFGGLD NIESDFLSMM PYYLVGLMIL RGASGFVSTY CLSWVSGKVV
110 120 130 140 150
MNLRRGLFNH FMKMPVSFFD KESSGALLSR ITYDSEQVAS ATSSALVSMV
160 170 180 190 200
REGASIIGLM ALMFWNSWQL SAILLVIAPV VAFSIRLVSK RFRKISKNMQ
210 220 230 240 250
DAMGSVTSSA EQMLKGHKVV LSYGGQEVEK QRFDSVSNNM RQQTMKLVSA
260 270 280 290 300
QAIANPVIQV IASFALVVVL VLANSEALRA ELTPGTFAVV FGAMFGLMRP
310 320 330 340 350
LKALTNVTSQ FQRGMAACQT LFELMDLEAE EDNGKHKIAR VNGDIQVKNV
360 370 380 390 400
TFTYPTKDTP ALRNVSFDLP AGKTLALVGR SGSGKSTIAN LLTRFYDIDS
410 420 430 440 450
GELILDGREV KDYQLSNLRD QVAVVSQNVH LFNDTIANNI AYASGDSFSR
460 470 480 490 500
ADIEKAAELA YAMDFIKGMP KGLDTMIGEN GVSLSGGQRQ RLAIARALLR
510 520 530 540 550
NAPVLILDEA TSALDTESER AIQSALEELQ KDRTVLVIAH RLSTIEGADQ
560 570 580
ILVVDDGEII ERGTHGELIK HDGAYAQLHR IQFGD
Length:585
Mass (Da):64,024
Last modified:July 5, 2004 - v1
Checksum:iA9406ACAB0B5977B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378670 Genomic DNA. Translation: CAG20770.1.
RefSeqiWP_011219054.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG20770; CAG20770; PBPRA2385.
KEGGippr:PBPRA2385.

Similar proteinsi

Entry informationi

Entry nameiMSBA_PHOPR
AccessioniPrimary (citable) accession number: Q6LPK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families