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Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton acceptorUniRule annotation
Active sitei60 – 601Proton acceptorUniRule annotation

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpAUniRule annotation
Ordered Locus Names:PBPRA2491
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Tryptophan synthase alpha chainPRO_0000098821Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA2491.

Structurei

3D structure databases

ProteinModelPortaliQ6LPA3.
SMRiQ6LPA3. Positions 1-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0159.
HOGENOMiHOG000223814.
KOiK01695.
OMAiGYFNPIH.
OrthoDBiEOG6RVG0K.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamiPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LPA3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRYQELFNR LAAKNEGAFV PFVTIGDPTP EQSMKIIDTL VASGADALEL
60 70 80 90 100
GIPFSDPLAD GPTIQAATIR ALESGTTPIV CFELLTQIRA KYPDMPIGLL
110 120 130 140 150
MYANLVFTAG IETFYKKCAD AGVDSVLIAD VPIKESEEFR VAAEKYGIHP
160 170 180 190 200
IFIAPPNATD ETLKSVSELG GGYTYLLSRA GVTGAETKAG KPIRHLVESL
210 220 230 240 250
TKHNAPPALL GFGISEPAQV KEAIEAGAAG AISGSAVVKI IENNLSDHTA
260
MLDNLGQFIR DMKAASKLS
Length:269
Mass (Da):28,551
Last modified:July 5, 2004 - v1
Checksum:iFE0B0F1EB6BF3DF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378671 Genomic DNA. Translation: CAG20873.1.
RefSeqiYP_130675.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG20873; CAG20873; PBPRA2491.
GeneIDi3125234.
KEGGippr:PBPRA2491.
PATRICi22935974. VBIPhoPro109272_2680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378671 Genomic DNA. Translation: CAG20873.1.
RefSeqiYP_130675.1. NC_006370.1.

3D structure databases

ProteinModelPortaliQ6LPA3.
SMRiQ6LPA3. Positions 1-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi298386.PBPRA2491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG20873; CAG20873; PBPRA2491.
GeneIDi3125234.
KEGGippr:PBPRA2491.
PATRICi22935974. VBIPhoPro109272_2680.

Phylogenomic databases

eggNOGiCOG0159.
HOGENOMiHOG000223814.
KOiK01695.
OMAiGYFNPIH.
OrthoDBiEOG6RVG0K.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamiPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiTRPA_PHOPR
AccessioniPrimary (citable) accession number: Q6LPA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.