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Q6LPA3 (TRPA_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan synthase alpha chain

EC=4.2.1.20
Gene names
Name:trpA
Ordered Locus Names:PBPRA2491
OrganismPhotobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]
Taxonomic identifier74109 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity. HAMAP-Rule MF_00131

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00131

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00131

Subunit structure

Tetramer of two alpha and two beta chains By similarity.

Sequence similarities

Belongs to the TrpA family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontryptophan synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Tryptophan synthase alpha chain HAMAP-Rule MF_00131
PRO_0000098821

Sites

Active site491Proton acceptor By similarity
Active site601Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LPA3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: FE0B0F1EB6BF3DF8

FASTA26928,551
        10         20         30         40         50         60 
MDRYQELFNR LAAKNEGAFV PFVTIGDPTP EQSMKIIDTL VASGADALEL GIPFSDPLAD 

        70         80         90        100        110        120 
GPTIQAATIR ALESGTTPIV CFELLTQIRA KYPDMPIGLL MYANLVFTAG IETFYKKCAD 

       130        140        150        160        170        180 
AGVDSVLIAD VPIKESEEFR VAAEKYGIHP IFIAPPNATD ETLKSVSELG GGYTYLLSRA 

       190        200        210        220        230        240 
GVTGAETKAG KPIRHLVESL TKHNAPPALL GFGISEPAQV KEAIEAGAAG AISGSAVVKI 

       250        260 
IENNLSDHTA MLDNLGQFIR DMKAASKLS 

« Hide

References

[1]"Life at depth: Photobacterium profundum genome sequence and expression analysis."
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.
Science 307:1459-1461(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR378671 Genomic DNA. Translation: CAG20873.1.
RefSeqYP_130675.1. NC_006370.1.

3D structure databases

ProteinModelPortalQ6LPA3.
SMRQ6LPA3. Positions 1-267.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING298386.PBPRA2491.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG20873; CAG20873; PBPRA2491.
GeneID3125234.
KEGGppr:PBPRA2491.
PATRIC22935974. VBIPhoPro109272_2680.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0159.
HOGENOMHOG000223814.
KOK01695.
OMAHECALIP.
OrthoDBEOG6RVG0K.

Enzyme and pathway databases

UniPathwayUPA00035; UER00044.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00131. Trp_synth_alpha.
InterProIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR00262. trpA. 1 hit.
PROSITEPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPA_PHOPR
AccessionPrimary (citable) accession number: Q6LPA3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways