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Q6LPA3

- TRPA_PHOPR

UniProt

Q6LPA3 - TRPA_PHOPR

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Protein

Tryptophan synthase alpha chain

Gene
trpA, PBPRA2491
Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton acceptor By similarity
Active sitei60 – 601Proton acceptor By similarity

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chain (EC:4.2.1.20)
Gene namesi
Name:trpA
Ordered Locus Names:PBPRA2491
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Tryptophan synthase alpha chainUniRule annotationPRO_0000098821Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains By similarity.

Protein-protein interaction databases

STRINGi298386.PBPRA2491.

Structurei

3D structure databases

ProteinModelPortaliQ6LPA3.
SMRiQ6LPA3. Positions 1-267.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.

Phylogenomic databases

eggNOGiCOG0159.
HOGENOMiHOG000223814.
KOiK01695.
OMAiHECALIP.
OrthoDBiEOG6RVG0K.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamiPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LPA3-1 [UniParc]FASTAAdd to Basket

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MDRYQELFNR LAAKNEGAFV PFVTIGDPTP EQSMKIIDTL VASGADALEL    50
GIPFSDPLAD GPTIQAATIR ALESGTTPIV CFELLTQIRA KYPDMPIGLL 100
MYANLVFTAG IETFYKKCAD AGVDSVLIAD VPIKESEEFR VAAEKYGIHP 150
IFIAPPNATD ETLKSVSELG GGYTYLLSRA GVTGAETKAG KPIRHLVESL 200
TKHNAPPALL GFGISEPAQV KEAIEAGAAG AISGSAVVKI IENNLSDHTA 250
MLDNLGQFIR DMKAASKLS 269
Length:269
Mass (Da):28,551
Last modified:July 5, 2004 - v1
Checksum:iFE0B0F1EB6BF3DF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378671 Genomic DNA. Translation: CAG20873.1.
RefSeqiYP_130675.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG20873; CAG20873; PBPRA2491.
GeneIDi3125234.
KEGGippr:PBPRA2491.
PATRICi22935974. VBIPhoPro109272_2680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378671 Genomic DNA. Translation: CAG20873.1 .
RefSeqi YP_130675.1. NC_006370.1.

3D structure databases

ProteinModelPortali Q6LPA3.
SMRi Q6LPA3. Positions 1-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA2491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG20873 ; CAG20873 ; PBPRA2491 .
GeneIDi 3125234.
KEGGi ppr:PBPRA2491.
PATRICi 22935974. VBIPhoPro109272_2680.

Phylogenomic databases

eggNOGi COG0159.
HOGENOMi HOG000223814.
KOi K01695.
OMAi HECALIP.
OrthoDBi EOG6RVG0K.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00044 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00131. Trp_synth_alpha.
InterProi IPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view ]
Pfami PF00290. Trp_syntA. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR00262. trpA. 1 hit.
PROSITEi PS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiTRPA_PHOPR
AccessioniPrimary (citable) accession number: Q6LPA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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