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Q6LPA3

- TRPA_PHOPR

UniProt

Q6LPA3 - TRPA_PHOPR

Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton acceptorUniRule annotation
    Active sitei60 – 601Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
    Gene namesi
    Name:trpAUniRule annotation
    Ordered Locus Names:PBPRA2491
    OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
    Taxonomic identifieri74109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
    ProteomesiUP000000593: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Tryptophan synthase alpha chainPRO_0000098821Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi298386.PBPRA2491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LPA3.
    SMRiQ6LPA3. Positions 1-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0159.
    HOGENOMiHOG000223814.
    KOiK01695.
    OMAiHECALIP.
    OrthoDBiEOG6RVG0K.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00131. Trp_synth_alpha.
    InterProiIPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view]
    PfamiPF00290. Trp_syntA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00262. trpA. 1 hit.
    PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6LPA3-1 [UniParc]FASTAAdd to Basket

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    MDRYQELFNR LAAKNEGAFV PFVTIGDPTP EQSMKIIDTL VASGADALEL    50
    GIPFSDPLAD GPTIQAATIR ALESGTTPIV CFELLTQIRA KYPDMPIGLL 100
    MYANLVFTAG IETFYKKCAD AGVDSVLIAD VPIKESEEFR VAAEKYGIHP 150
    IFIAPPNATD ETLKSVSELG GGYTYLLSRA GVTGAETKAG KPIRHLVESL 200
    TKHNAPPALL GFGISEPAQV KEAIEAGAAG AISGSAVVKI IENNLSDHTA 250
    MLDNLGQFIR DMKAASKLS 269
    Length:269
    Mass (Da):28,551
    Last modified:July 5, 2004 - v1
    Checksum:iFE0B0F1EB6BF3DF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378671 Genomic DNA. Translation: CAG20873.1.
    RefSeqiYP_130675.1. NC_006370.1.

    Genome annotation databases

    EnsemblBacteriaiCAG20873; CAG20873; PBPRA2491.
    GeneIDi3125234.
    KEGGippr:PBPRA2491.
    PATRICi22935974. VBIPhoPro109272_2680.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378671 Genomic DNA. Translation: CAG20873.1 .
    RefSeqi YP_130675.1. NC_006370.1.

    3D structure databases

    ProteinModelPortali Q6LPA3.
    SMRi Q6LPA3. Positions 1-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 298386.PBPRA2491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG20873 ; CAG20873 ; PBPRA2491 .
    GeneIDi 3125234.
    KEGGi ppr:PBPRA2491.
    PATRICi 22935974. VBIPhoPro109272_2680.

    Phylogenomic databases

    eggNOGi COG0159.
    HOGENOMi HOG000223814.
    KOi K01695.
    OMAi HECALIP.
    OrthoDBi EOG6RVG0K.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00131. Trp_synth_alpha.
    InterProi IPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view ]
    Pfami PF00290. Trp_syntA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00262. trpA. 1 hit.
    PROSITEi PS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS9.

    Entry informationi

    Entry nameiTRPA_PHOPR
    AccessioniPrimary (citable) accession number: Q6LPA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3