Q6LPA3 (TRPA_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan synthase alpha chain
EC=4.2.1.20

Gene names

Name:	trpA
Ordered Locus Names:	PBPRA2491

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity. HAMAP-Rule MF_00131
Catalytic activity	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00131
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00131
Subunit structure	Tetramer of two alpha and two beta chains By similarity.
Sequence similarities	Belongs to the TrpA family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	tryptophan synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Tryptophan synthase alpha chain HAMAP-Rule MF_00131		PRO_0000098821
Sites
	Active site	49	1	Proton acceptor By similarity
	Active site	60	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LPA3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: FE0B0F1EB6BF3DF8	FASTA	269	28,551
	10 20 30 40 50 60 MDRYQELFNR LAAKNEGAFV PFVTIGDPTP EQSMKIIDTL VASGADALEL GIPFSDPLAD 70 80 90 100 110 120 GPTIQAATIR ALESGTTPIV CFELLTQIRA KYPDMPIGLL MYANLVFTAG IETFYKKCAD 130 140 150 160 170 180 AGVDSVLIAD VPIKESEEFR VAAEKYGIHP IFIAPPNATD ETLKSVSELG GGYTYLLSRA 190 200 210 220 230 240 GVTGAETKAG KPIRHLVESL TKHNAPPALL GFGISEPAQV KEAIEAGAAG AISGSAVVKI 250 260 IENNLSDHTA MLDNLGQFIR DMKAASKLS

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SS9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR378671 Genomic DNA. Translation: CAG20873.1.
RefSeq	YP_130675.1. NC_006370.1.
3D structure databases
ProteinModelPortal	Q6LPA3.
SMR	Q6LPA3. Positions 1-267.
ModBase	Search...
Protein-protein interaction databases
STRING	298386.PBPRA2491.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG20873; CAG20873; PBPRA2491.
GeneID	3125234.
KEGG	ppr:PBPRA2491.
PATRIC	22935974. VBIPhoPro109272_2680.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0159.
HOGENOM	HOG000223814.
KO	K01695.
OMA	VFICPPN.
ProtClustDB	PRK13111.
Enzyme and pathway databases
UniPathway	UPA00035; UER00044.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00131. Trp_synth_alpha.
InterPro	IPR013785. Aldolase_TIM. IPR011060. RibuloseP-bd_barrel. IPR018204. Trp_synthase_alpha_AS. IPR002028. Trp_synthase_suA. [Graphical view]
Pfam	PF00290. Trp_syntA. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR00262. trpA. 1 hit.
PROSITE	PS00167. TRP_SYNTHASE_ALPHA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPA_PHOPR

Accession

Primary (citable) accession number: Q6LPA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program