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Q6LNJ0 (FTHS_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:PBPRA2764
OrganismPhotobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]
Taxonomic identifier74109 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Protein attributes

Sequence length584 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 584584Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199367

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LNJ0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C1887713A5A6490A

FASTA58461,957
        10         20         30         40         50         60 
MKSDIQICRD TALTPIDQIA LMAGIEPQDL TPQGTLKAKV KPSILNRLAD KPEGKLVLVT 

        70         80         90        100        110        120 
AITPTPLGEG KTVTTIGLAQ GLAKINKRVI ACIRQPSMGP VFGVKGGAAG GGYSQVAPME 

       130        140        150        160        170        180 
KLNLHLTGDI HAVTAAHNLA AAALDARLYH EERHGYEAFS DKTGLPALRI DIKNIVWKRV 

       190        200        210        220        230        240 
MDHNDRALRM ITVGKNEAGK AINGLEREDG FDISAASEIM AILALSKDLA DMRQRIGRVV 

       250        260        270        280        290        300 
LAYNIDGNPI TAEDLQVAGA MTVTMCEAIE PTLMQTLEGV ATLIHAGPFA NIAHGNSSII 

       310        320        330        340        350        360 
ADRIALKLSE FTVTEGGFGS DMGFEKACNI KAQQADRGPD CAVVVATLRG LKANSGLYDL 

       370        380        390        400        410        420 
RPGQALPDAI FSPDEKALIA GFDNLKWHIR NAAQYGLPVV VAINRFPQDT DVELELLKNM 

       430        440        450        460        470        480 
VADTDFSTYV GVAISEAFGK GGEGATELAQ AVVKACETPA NFKPLYSLSQ SLEEKLMAVA 

       490        500        510        520        530        540 
EVGYGARSIE LSDCAKEQLA TLKKHGHDNL AVCLAKTPLS ITTDPGIKGA PSDFVVPVRE 

       550        560        570        580 
LKLCAGAGFV YALCGNVMTM PGLPEKPAYM NLDIDADGNI VGLS 

« Hide

References

[1]"Life at depth: Photobacterium profundum genome sequence and expression analysis."
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.
Science 307:1459-1461(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR378672 Genomic DNA. Translation: CAG21136.1.
RefSeqYP_130938.1. NC_006370.1.

3D structure databases

ProteinModelPortalQ6LNJ0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING298386.PBPRA2764.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG21136; CAG21136; PBPRA2764.
GeneID3122167.
KEGGppr:PBPRA2764.
PATRIC22936548. VBIPhoPro109272_2957.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMANTIVQRI.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_PHOPR
AccessionPrimary (citable) accession number: Q6LNJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways