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Q6LNJ0

- FTHS_PHOPR

UniProt

Q6LNJ0 - FTHS_PHOPR

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:PBPRA2764
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Formate--tetrahydrofolate ligasePRO_0000199367Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA2764.

Structurei

3D structure databases

ProteinModelPortaliQ6LNJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiNTIVQRI.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LNJ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIQICRD TALTPIDQIA LMAGIEPQDL TPQGTLKAKV KPSILNRLAD
60 70 80 90 100
KPEGKLVLVT AITPTPLGEG KTVTTIGLAQ GLAKINKRVI ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYSQVAPME KLNLHLTGDI HAVTAAHNLA AAALDARLYH
160 170 180 190 200
EERHGYEAFS DKTGLPALRI DIKNIVWKRV MDHNDRALRM ITVGKNEAGK
210 220 230 240 250
AINGLEREDG FDISAASEIM AILALSKDLA DMRQRIGRVV LAYNIDGNPI
260 270 280 290 300
TAEDLQVAGA MTVTMCEAIE PTLMQTLEGV ATLIHAGPFA NIAHGNSSII
310 320 330 340 350
ADRIALKLSE FTVTEGGFGS DMGFEKACNI KAQQADRGPD CAVVVATLRG
360 370 380 390 400
LKANSGLYDL RPGQALPDAI FSPDEKALIA GFDNLKWHIR NAAQYGLPVV
410 420 430 440 450
VAINRFPQDT DVELELLKNM VADTDFSTYV GVAISEAFGK GGEGATELAQ
460 470 480 490 500
AVVKACETPA NFKPLYSLSQ SLEEKLMAVA EVGYGARSIE LSDCAKEQLA
510 520 530 540 550
TLKKHGHDNL AVCLAKTPLS ITTDPGIKGA PSDFVVPVRE LKLCAGAGFV
560 570 580
YALCGNVMTM PGLPEKPAYM NLDIDADGNI VGLS
Length:584
Mass (Da):61,957
Last modified:July 5, 2004 - v1
Checksum:iC1887713A5A6490A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378672 Genomic DNA. Translation: CAG21136.1.
RefSeqiYP_130938.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG21136; CAG21136; PBPRA2764.
GeneIDi3122167.
KEGGippr:PBPRA2764.
PATRICi22936548. VBIPhoPro109272_2957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378672 Genomic DNA. Translation: CAG21136.1 .
RefSeqi YP_130938.1. NC_006370.1.

3D structure databases

ProteinModelPortali Q6LNJ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA2764.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG21136 ; CAG21136 ; PBPRA2764 .
GeneIDi 3122167.
KEGGi ppr:PBPRA2764.
PATRICi 22936548. VBIPhoPro109272_2957.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi NTIVQRI.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiFTHS_PHOPR
AccessioniPrimary (citable) accession number: Q6LNJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3