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Q6LNJ0

- FTHS_PHOPR

UniProt

Q6LNJ0 - FTHS_PHOPR

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:PBPRA2764
    OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
    Taxonomic identifieri74109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
    ProteomesiUP000000593: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 584584Formate--tetrahydrofolate ligasePRO_0000199367Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi298386.PBPRA2764.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LNJ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiNTIVQRI.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6LNJ0-1 [UniParc]FASTAAdd to Basket

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    MKSDIQICRD TALTPIDQIA LMAGIEPQDL TPQGTLKAKV KPSILNRLAD    50
    KPEGKLVLVT AITPTPLGEG KTVTTIGLAQ GLAKINKRVI ACIRQPSMGP 100
    VFGVKGGAAG GGYSQVAPME KLNLHLTGDI HAVTAAHNLA AAALDARLYH 150
    EERHGYEAFS DKTGLPALRI DIKNIVWKRV MDHNDRALRM ITVGKNEAGK 200
    AINGLEREDG FDISAASEIM AILALSKDLA DMRQRIGRVV LAYNIDGNPI 250
    TAEDLQVAGA MTVTMCEAIE PTLMQTLEGV ATLIHAGPFA NIAHGNSSII 300
    ADRIALKLSE FTVTEGGFGS DMGFEKACNI KAQQADRGPD CAVVVATLRG 350
    LKANSGLYDL RPGQALPDAI FSPDEKALIA GFDNLKWHIR NAAQYGLPVV 400
    VAINRFPQDT DVELELLKNM VADTDFSTYV GVAISEAFGK GGEGATELAQ 450
    AVVKACETPA NFKPLYSLSQ SLEEKLMAVA EVGYGARSIE LSDCAKEQLA 500
    TLKKHGHDNL AVCLAKTPLS ITTDPGIKGA PSDFVVPVRE LKLCAGAGFV 550
    YALCGNVMTM PGLPEKPAYM NLDIDADGNI VGLS 584
    Length:584
    Mass (Da):61,957
    Last modified:July 5, 2004 - v1
    Checksum:iC1887713A5A6490A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378672 Genomic DNA. Translation: CAG21136.1.
    RefSeqiYP_130938.1. NC_006370.1.

    Genome annotation databases

    EnsemblBacteriaiCAG21136; CAG21136; PBPRA2764.
    GeneIDi3122167.
    KEGGippr:PBPRA2764.
    PATRICi22936548. VBIPhoPro109272_2957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378672 Genomic DNA. Translation: CAG21136.1 .
    RefSeqi YP_130938.1. NC_006370.1.

    3D structure databases

    ProteinModelPortali Q6LNJ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 298386.PBPRA2764.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG21136 ; CAG21136 ; PBPRA2764 .
    GeneIDi 3122167.
    KEGGi ppr:PBPRA2764.
    PATRICi 22936548. VBIPhoPro109272_2957.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi NTIVQRI.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS9.

    Entry informationi

    Entry nameiFTHS_PHOPR
    AccessioniPrimary (citable) accession number: Q6LNJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3