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Q6LN22

- GLND_PHOPR

UniProt

Q6LN22 - GLND_PHOPR

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Protein

Bifunctional uridylyltransferase/uridylyl-removing enzyme

Gene
glnD, PBPRA2970
Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism By similarity.UniRule annotation

Catalytic activityi

UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII].UniRule annotation
Uridylyl-[protein-PII] + H2O = UMP + [protein-PII].UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity By similarity.UniRule annotation

GO - Molecular functioni

  1. [protein-PII] uridylyltransferase activity Source: UniProtKB-HAMAP
  2. amino acid binding Source: InterPro
  3. metal ion binding Source: InterPro
  4. phosphoric diester hydrolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
  2. regulation of nitrogen utilization Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional uridylyltransferase/uridylyl-removing enzyme
Short name:
UTase/UR
Alternative name(s):
Bifunctional [protein-PII] modification enzyme
Bifunctional nitrogen sensor protein
Including the following 2 domains:
[Protein-PII] uridylyltransferase (EC:2.7.7.59)
Short name:
PII uridylyltransferase
Short name:
UTase
[Protein-PII]-UMP uridylyl-removing enzyme (EC:3.1.4.-)
Short name:
UR
Gene namesi
Name:glnD
Ordered Locus Names:PBPRA2970
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Bifunctional uridylyltransferase/uridylyl-removing enzymeUniRule annotationPRO_0000192750Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA2970.

Structurei

3D structure databases

ProteinModelPortaliQ6LN22.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini455 – 588134HDAdd
BLAST
Domaini696 – 77984ACT 1Add
BLAST
Domaini802 – 87473ACT 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 336336UridylyltransferaseUniRule annotationAdd
BLAST
Regioni337 – 695359Uridylyl-removingUniRule annotationAdd
BLAST

Domaini

Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the GlnD family.
Contains 2 ACT domains.
Contains 1 HD domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2844.
HOGENOMiHOG000261778.
KOiK00990.
OMAiHHLLMSV.
OrthoDBiEOG6CCH44.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
HAMAPiMF_00277. PII_uridylyl_transf.
InterProiIPR002912. ACT_dom.
IPR010043. GlnD_Uridyltrans.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR002934. Nucleotidyltransferase.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF08335. GlnD_UR_UTase. 1 hit.
PF01966. HD. 1 hit.
PF01909. NTP_transf_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006288. PII_uridyltransf. 1 hit.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01693. UTase_glnD. 1 hit.
PROSITEiPS51671. ACT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LN22-1 [UniParc]FASTAAdd to Basket

« Hide

MIDTSTITNP QTLPVEAITQ ENLRNTLEQF AEQQKQQFIQ HRPVTDLVLS    50
RSTFIDKLLI RLWEHYEVNQ YPDIALVAVG GYGRGELHPL SDVDILILSA 100
QPLSDETGRI VSKFLTFLWD LRLEVGHSVR TIDDCIEIGN DDLTVATNLT 150
EARILCGSED VFQCLQERIN AGNFWPSEDF YRAKLEEQKT RHARYHDTTY 200
NLEPDIKSSP GGLRDIHTLS WVARRHFGAT SLLEMSRFGF LTDAEYRELV 250
ECQDSLWRIR FALHIELRRY DNRLTFSHQP SVAENLGYTG EGNRGVEMMM 300
KEFYRTLRRV LELNKMLLQL FDQAILDNGK TVETIQLSDD FQIRGHLIEA 350
TKPALFQARP ETILDMFLHI AQNGDIEGIA APTLRQLRTA RQRLNVFLVD 400
IPEAREKFME LVRQPNTLQK AFRLMHRHGV LSAYLPQWSQ IVGQMQFDLF 450
HVYTVDEHSV RLIKNLNKFN DPENRERHPI CCEVYPRIIK KELLTIAAIF 500
HDIAKGRGGD HSELGAIEAR KFCIQHGLSR PETNLIAWLV QKHLLMSVTA 550
QRRDIYDPEV VAEFAKEVRD EERLDYLICL TVADICATNQ ELWNSWKRTL 600
LAELYYSTQK ALRRGLENTP DVRDRIRHNQ QLSSAILRGK GFAPREIEVL 650
WKRFKADYFL RHTHKQLAWH AEALLTHDHD KPLILLSKKA TRGGTEVFVY 700
NKDKAKLFAI VVSELDKKNL SVHDAQIMNS KDGYTLDTFM VLDPSGKTIP 750
ENRHNTIRRA LVNALTKMKS ERKNKRAPRK LMHFNVKTQV DFLPTKTGKK 800
TTMELIALDT PGLLARIGAV FAKQKVSLQA AKITTIGERA EDFFILVNEH 850
GSPLTEEHQQ ALKEALIIKL TPQD 874
Length:874
Mass (Da):100,797
Last modified:July 5, 2004 - v1
Checksum:iBD18CA770614C067
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378672 Genomic DNA. Translation: CAG21304.1.
RefSeqiYP_131106.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG21304; CAG21304; PBPRA2970.
GeneIDi3123062.
KEGGippr:PBPRA2970.
PATRICi22936978. VBIPhoPro109272_3134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378672 Genomic DNA. Translation: CAG21304.1 .
RefSeqi YP_131106.1. NC_006370.1.

3D structure databases

ProteinModelPortali Q6LN22.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA2970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG21304 ; CAG21304 ; PBPRA2970 .
GeneIDi 3123062.
KEGGi ppr:PBPRA2970.
PATRICi 22936978. VBIPhoPro109272_3134.

Phylogenomic databases

eggNOGi COG2844.
HOGENOMi HOG000261778.
KOi K00990.
OMAi HHLLMSV.
OrthoDBi EOG6CCH44.

Family and domain databases

Gene3Di 1.10.3210.10. 1 hit.
HAMAPi MF_00277. PII_uridylyl_transf.
InterProi IPR002912. ACT_dom.
IPR010043. GlnD_Uridyltrans.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR002934. Nucleotidyltransferase.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF08335. GlnD_UR_UTase. 1 hit.
PF01966. HD. 1 hit.
PF01909. NTP_transf_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006288. PII_uridyltransf. 1 hit.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01693. UTase_glnD. 1 hit.
PROSITEi PS51671. ACT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiGLND_PHOPR
AccessioniPrimary (citable) accession number: Q6LN22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi