Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease 3

Gene

rnc

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40MagnesiumUniRule annotation1
Active sitei44UniRule annotation1
Metal bindingi113MagnesiumUniRule annotation1
Active sitei116UniRule annotation1
Metal bindingi116MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:PBPRA3089
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002285631 – 224Ribonuclease 3Add BLAST224

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA3089

Structurei

3D structure databases

ProteinModelPortaliQ6LMS2
SMRiQ6LMS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 127RNase IIIUniRule annotationAdd BLAST123
Domaini154 – 224DRBMUniRule annotationAdd BLAST71

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0571 LUCA
HOGENOMiHOG000246809
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LMS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSPANRLQR RLGYQFNSSE LMTLSLTHRS ANGKHNERLE FLGDSILSFV
60 70 80 90 100
IADDLYHRFP HVDEGDMSRM RATLVRGKTL AELGREFELG DYLLLGPGEL
110 120 130 140 150
KSGGFRRDSI LADCVEAIIG AIYLDSDTEQ VRKVILSWYQ SRLETIQPGI
160 170 180 190 200
NQKDPKTRLQ ECLQGRRLAL PAYTVTKVHG EAHNQEFTVQ CEVTGLDKPV
210 220
IGKGSSRRKA EQAAAELALK QLES
Length:224
Mass (Da):25,130
Last modified:July 5, 2004 - v1
Checksum:i403EEF64008F2D20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378673 Genomic DNA Translation: CAG21405.1
RefSeqiWP_011219664.1, NC_006370.1

Genome annotation databases

EnsemblBacteriaiCAG21405; CAG21405; PBPRA3089
KEGGippr:PBPRA3089

Similar proteinsi

Entry informationi

Entry nameiRNC_PHOPR
AccessioniPrimary (citable) accession number: Q6LMS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health