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Protein

Sulfate adenylyltransferase subunit 2

Gene

cysD

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + sulfate = diphosphate + adenylyl sulfate.UniRule annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes sulfite from sulfate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase subunit 1 (cysN), Sulfate adenylyltransferase subunit 2 (cysD)
  2. Adenylyl-sulfate kinase (SF2773)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPRO298386-WGS:GSSB-3304-MONOMER.
UniPathwayiUPA00140; UER00204.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate adenylyltransferase subunit 2UniRule annotation (EC:2.7.7.4UniRule annotation)
Alternative name(s):
ATP-sulfurylase small subunitUniRule annotation
Sulfate adenylate transferaseUniRule annotation
Short name:
SATUniRule annotation
Gene namesi
Name:cysDUniRule annotation
Ordered Locus Names:PBPRA3311
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Sulfate adenylyltransferase subunit 2PRO_0000340212Add
BLAST

Proteomic databases

PRIDEiQ6LM68.

Interactioni

Subunit structurei

Heterodimer composed of CysD, the smaller subunit, and CysN.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA3311.

Structurei

3D structure databases

ProteinModelPortaliQ6LM68.
SMRiQ6LM68. Positions 5-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAPS reductase family. CysD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C11. Bacteria.
COG0175. LUCA.
HOGENOMiHOG000263604.
KOiK00957.
OrthoDBiEOG6W45TZ.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00064. Sulf_adenylyltr_sub2.
InterProiIPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011784. SO4_adenylTrfase_ssu.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF002936. CysDAde_trans. 1 hit.
TIGRFAMsiTIGR02039. CysD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LM68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPKRLTHLK QLEAESIHIL REVAAEFDNP VMMYSIGKDS SVMLHLARKA
60 70 80 90 100
FYPGKIPFPL LHVDTDWKFR EMIEFRDRTA EKYGFELLVH KNPEGMAMGI
110 120 130 140 150
SPFEHGSSKH TDVMKTQGLK QALNKYGFDA AFGGARRDEE KSRAKERIYS
160 170 180 190 200
FRDKNHSWDP KNQRPELWKT YNGQINKGES IRVFPLSNWT ELDIWQYIYL
210 220 230 240 250
ESIEIVPLYL SDIRPVVERD GMLIMADDDR LKLQPGEKIE YKSVRFRTLG
260 270 280 290 300
CYPLTGAIES KADTLPGIIE EMLVATSSER QGRAIDHDQS GSMELKKRQG

YF
Length:302
Mass (Da):34,996
Last modified:June 10, 2008 - v2
Checksum:i8B1EDEE3B1C9A878
GO

Sequence cautioni

The sequence CAG21609.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378673 Genomic DNA. Translation: CAG21609.1. Different initiation.
RefSeqiWP_041394548.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG21609; CAG21609; PBPRA3311.
KEGGippr:PBPRA3311.
PATRICi22937689. VBIPhoPro109272_3453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378673 Genomic DNA. Translation: CAG21609.1. Different initiation.
RefSeqiWP_041394548.1. NC_006370.1.

3D structure databases

ProteinModelPortaliQ6LM68.
SMRiQ6LM68. Positions 5-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi298386.PBPRA3311.

Proteomic databases

PRIDEiQ6LM68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG21609; CAG21609; PBPRA3311.
KEGGippr:PBPRA3311.
PATRICi22937689. VBIPhoPro109272_3453.

Phylogenomic databases

eggNOGiENOG4105C11. Bacteria.
COG0175. LUCA.
HOGENOMiHOG000263604.
KOiK00957.
OrthoDBiEOG6W45TZ.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00204.
BioCyciPPRO298386-WGS:GSSB-3304-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00064. Sulf_adenylyltr_sub2.
InterProiIPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011784. SO4_adenylTrfase_ssu.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF002936. CysDAde_trans. 1 hit.
TIGRFAMsiTIGR02039. CysD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1253 / SS9.

Entry informationi

Entry nameiCYSD_PHOPR
AccessioniPrimary (citable) accession number: Q6LM68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 11, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.