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Reviewed, UniProtKB/Swiss-Prot Q6LM59 (CYSI_PHOPR)

Last modified February 9, 2010. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Sulfite reductase [NADPH] hemoprotein beta-component
      Short name=SiR-HP
      Short name=SiRHP
    EC=1.8.1.2
Gene names
Name: cysI
Ordered Locus Names: PBPRA3320
OrganismPhotobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]
Taxonomic identifier74109 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Protein attributes

Sequence length563 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate By similarity. HAMAP MF_01540

Catalytic activity

H2S + 3 NADP+ + 3 H2O = sulfite + 3 NADPH. HAMAP MF_01540

Cofactor

Binds 1 siroheme per subunit By similarity. HAMAP MF_01540

Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP MF_01540

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. HAMAP MF_01540

Subunit structure

Alpha(8)-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein By similarity. HAMAP MF_01540

Sequence similarities

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 563563Sulfite reductase [NADPH] hemoprotein beta-component HAMAP MF_01540
PRO_0000199904

Sites

Metal binding4261Iron-sulfur (4Fe-4S) By similarity
Metal binding4321Iron-sulfur (4Fe-4S) By similarity
Metal binding4721Iron-sulfur (4Fe-4S) By similarity
Metal binding4761Iron (siroheme axial ligand) By similarity
Metal binding4761Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LM59-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E103B8C14064EBEE

FASTA56362,719
        10         20         30         40         50         60 
MTEQKLSDNE RLKRESNFLR GTIADDLQDR ITGGFTADNF QLIRFHGMYQ QDDRDIRAER 

        70         80         90        100        110        120 
AKQKLEPLHN VMLRARMPGG IITPTQWLAI DKFAEESSLY GSIRLTTRQT FQFHGVLKPN 

       130        140        150        160        170        180 
IKLMHQTLNS IGIDSIATAG DVNRNVLCTT NPIESELHQE AYEWAKKISE HLLPKTRAYA 

       190        200        210        220        230        240 
EIWLDGEKVE GGDEEPILGS NYLPRKFKTT VVIPPQNDVD VHANDLNFIA IADNGKLVGF 

       250        260        270        280        290        300 
NVLVGGGLAM THGDKTTYPR RADDFGFIPL VNTLEVAAAV VTTQRDWGNR SNRKNAKTKY 

       310        320        330        340        350        360 
TLDRVGVDVF KAEVEKRAGI TFEASRPYEF TDRGDRIGWV EGIDGKHHLA LFIENGRLLD 

       370        380        390        400        410        420 
TPGKPLKTGV AEIAKIHKGD FRMTANQNLI VAGVPAADKN KIEKIARDHG LIDDGVSEQR 

       430        440        450        460        470        480 
KNSMACVAFP TCPLAMAEAE RFLPDFVTDV EGVLAKHGLA EDDNIILRVT GCANGCGRAM 

       490        500        510        520        530        540 
LAEIGLVGKA PGRYNVHLGG NRNGTRVPKM YRENITVPQI MDEIDQLVGR WANEREDGED 

       550        560 
FGDFTVRTGI IEPVLVSKRD FYA 

« Hide

References

[1]"Life at depth: Photobacterium profundum genome sequence and expression analysis."
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.
Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR378673 Genomic DNA. Translation: CAG21618.1.
RefSeqYP_131420.1.

3D structure databases

SMRQ6LM59. Positions 72-562.
ModBaseSearch...

Genome annotation databases

GeneID3122708.
KEGGppr:PBPRA3320.
NMPDRfig|298386.1.peg.5527.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG626671.
OMAPGDNSVD.
PhylomeDBQ6LM59.

Enzyme and pathway databases

BioCycPPRO298386:PBPRA3320-MONOMER.
BRENDA1.8.1.2. 263915.

Family and domain databases

HAMAPMF_01540. CysI.
[Tree]
InterProIPR011786. CysI.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS.
[Graphical view]
PfamPF01077. NIR_SIR. 1 hit.
PF03460. NIR_SIR_ferr. 2 hits.
[Graphical view]
PRINTSPR00397. SIROHAEM.
TIGRFAMsTIGR02041. CysI. 1 hit.
PROSITEPS00365. NIR_SIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYSI_PHOPR
AccessionPrimary (citable) accession number: Q6LM59
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 5, 2004
Last modified: February 9, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents