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Protein

Alanine racemase

Gene

ALR

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway:iD-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (ALR), Alanine racemase (ALR)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei171 – 1711SubstrateUniRule annotation
Active sitei297 – 2971Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei345 – 3451Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPPRO298386-WGS:GSSB-3378-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Name:ALRImported
Ordered Locus Names:PBPRA3385Imported
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))Imported
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593 Componenti: Chromosome 1

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA3385.

Structurei

3D structure databases

ProteinModelPortaliQ6LM08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000279190.
KOiK01775.
OMAiCEAFAVT.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LM08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKLSLVAL ALMGQTTANA APLLVDFDNN EREERVQSSN AWLEIDTQAF
60 70 80 90 100
SGNIQLLQNQ LKADTKICAI MKADAYGNGI AGLMPSIIAN QVPCVGITSN
110 120 130 140 150
EEARVVRKHG FIGKIMRVRA ASKNEIEGGL QYQMEELIGT KAQADQIIEI
160 170 180 190 200
ARANGTTIPV HLALNTSGMG RNGLDLTTYE GQVEGVEIAG DPNLEIVGMM
210 220 230 240 250
THFPNEGLDE IKRKVKRFKV ETKWLMDSTD LKRKDVTLHV ANSYITLNLP
260 270 280 290 300
EAHLDMVRPG GMLYGDYPAT APYQRIVSFK THVASLHHFP AGSTIGYGST
310 320 330 340 350
AVLERDSVLA NLPIGYSDGF ARSLGNKAEV LINGQRARVM GMVSMNTTMV
360 370 380 390 400
DVTDIVDVQT NEEVVIFGRQ GFEEITGEET EEKSNRILPE HYTVWGATNP

RIYR
Length:404
Mass (Da):44,408
Last modified:July 5, 2004 - v1
Checksum:iBC0E50D155592F87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378673 Genomic DNA. Translation: CAG21670.1.

Genome annotation databases

EnsemblBacteriaiCAG21670; CAG21670; PBPRA3385.
KEGGippr:PBPRA3385.
PATRICi22937837. VBIPhoPro109272_3514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378673 Genomic DNA. Translation: CAG21670.1.

3D structure databases

ProteinModelPortaliQ6LM08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi298386.PBPRA3385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG21670; CAG21670; PBPRA3385.
KEGGippr:PBPRA3385.
PATRICi22937837. VBIPhoPro109272_3514.

Phylogenomic databases

HOGENOMiHOG000279190.
KOiK01775.
OMAiCEAFAVT.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciPPRO298386-WGS:GSSB-3378-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9Imported.

Entry informationi

Entry nameiQ6LM08_PHOPR
AccessioniPrimary (citable) accession number: Q6LM08
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.