Q6LLV5 (EFTU2_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor Tu 2
Short name=EF-Tu 2

Gene names

Name:	tuf2
Ordered Locus Names:	PBPRA3439

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity. HAMAP-Rule MF_00118
Subunit structure	Monomer By similarity. HAMAP-Rule MF_00118
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00118.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.
Sequence caution	The sequence CAG21723.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Elongation factor Tu 2 HAMAP-Rule MF_00118		PRO_0000337461
Regions
	Nucleotide binding	19 – 26	8	GTP By similarity
	Nucleotide binding	81 – 85	5	GTP By similarity
	Nucleotide binding	136 – 139	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LLV5 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: D5F08BE19A87DF6D	FASTA	394	43,220
	10 20 30 40 50 60 MSKEKFERLK PHVNVGTIGH VDHGKTTLTA AICTVLAKVY GGDAKDFASI DNAPEERERG 70 80 90 100 110 120 ITISTSHVEY DTPARHYAHV DCPGHADYVK NMITGAAQMD GGILVVAATD GPMPQTREHI 130 140 150 160 170 180 LLGRQVGIPY IIVFMNKCDM VDDEELLELV EMEVRELLSE YDFPGDDCPV IMGSALGALN 190 200 210 220 230 240 GEAQWEEKII ELAEALDNYI PEPERAIDLP FILPIEDVFS IQGRGTVVTG RVEQGIVRIG 250 260 270 280 290 300 EEVAIIGIKE TTTTTCTGVE MFRKLLDEGR AGENVGVLLR GTKRDDVERG QVLAKPGSIT 310 320 330 340 350 360 PHTTFESEIY VLSKDEGGRH TPFFKGYRPQ FYFRTTDVTG TIELPEGVEM VMPGDNIQMK 370 380 390 VTLIAPIAMD EGLRFAIREG GRTVGAGVVA KIFE

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SS9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR378674 Genomic DNA. Translation: CAG21723.1. Different initiation.
RefSeq	YP_131525.2. NC_006370.1.
3D structure databases
ProteinModelPortal	Q6LLV5.
SMR	Q6LLV5. Positions 10-393.
ModBase	Search...
Protein-protein interaction databases
STRING	298386.PBPRA3439.
Proteomic databases
PRIDE	Q6LLV5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG21723; CAG21723; PBPRA3439.
GeneID	3124810.
KEGG	ppr:PBPRA3439.
PATRIC	22937951. VBIPhoPro109272_3571.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000229290.
KO	K02358.
ProtClustDB	PRK12735.
Family and domain databases
HAMAP	MF_00118_B. EF_Tu_B.
InterPro	IPR000795. EF_GTP-bd_dom. IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR009001. Transl_elong_EF1A/Init_IF2_C. IPR004161. Transl_elong_EFTu/EF1A_2. IPR004541. Transl_elong_EFTu/EF1A_bac/org. IPR004160. Transl_elong_EFTu/EF1A_C. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF03143. GTP_EFTU_D3. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SUPFAM	SSF50465. Elong_init_C. 1 hit. SSF52540. SSF52540. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00485. EF-Tu. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFTU2_PHOPR

Accession

Primary (citable) accession number: Q6LLV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	May 29, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program