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Protein

Vitamin B12 transporter BtuB

Gene

btuB

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin B12 transporter BtuBUniRule annotation
Alternative name(s):
Cobalamin receptorUniRule annotation
Outer membrane cobalamin translocatorUniRule annotation
Gene namesi
Name:btuBUniRule annotation
Ordered Locus Names:PBPRA3464
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

Subcellular locationi

  • Cell outer membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121UniRule annotationAdd
BLAST
Chaini22 – 606585Vitamin B12 transporter BtuBPRO_0000003485Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA3464.

Structurei

3D structure databases

ProteinModelPortaliQ6LLU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi28 – 358TonB box
Motifi589 – 60618TonB C-terminal boxAdd
BLAST

Sequence similaritiesi

Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. [View classification]UniRule annotation

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CHI. Bacteria.
COG4206. LUCA.
HOGENOMiHOG000269547.
KOiK16092.
OMAiGHWAVNA.
OrthoDBiEOG68H83J.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
HAMAPiMF_01531. BtuB.
InterProiIPR010101. B12_transptr_BtuB.
IPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6LLU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTLLAVAL APLCLPSQVF AADESSNDVM VVTANRFEQP IKNVIAPISV
60 70 80 90 100
VTKEEIDAIQ AKSIAEVLRR LPGVQVVSGG YGQATEVYVR GTTSRHLLVM
110 120 130 140 150
INGVRIGSAT LGSADFSQIP LTGIERIELI RGSRAALYGS DAIGGVLNII
160 170 180 190 200
TAYQPGESVA EVTAGGGSDG FYQLGGSVAG GLGESGWGKI ALKTEGADGF
210 220 230 240 250
SARKEPFEQD DDGFKNSNVV AEVGTHVGDH WKLSLQGYYH DGESDYDDSY
260 270 280 290 300
GAPHAQSESS LFNIAAKAGY SNDKLDSQFT VAQNQDENRN FNDVSSGSKI
310 320 330 340 350
KTERTVANWQ NHYQLTDGLE LGGGLEWYRD SVSNTGTQYA EDERDNTAVY
360 370 380 390 400
LTSIYRISDW QFEGSVRTDD NDSYGTNNTW QLATAYNITS ELKVSANAGT
410 420 430 440 450
GFKAPTFNDL YWPDSGNPNL KPEESKNYEI SLSGTHQLLD WSITGYQSEI
460 470 480 490 500
DQLIAWAPKD ASNPSGDWIP MNVDEAEIQG IELTAGFATG MLYHDVSYDY
510 520 530 540 550
LDAKDKGLDK QLIRRSKDSA KWNVSYLAEQ WQLDVSAIYK GTSYDDAANT
560 570 580 590 600
KKLDAYTLVD IAASYFVTDN LSVRGRIANL FDKDYVAKET YNVQERSYYA

TATYKF
Length:606
Mass (Da):66,298
Last modified:July 5, 2004 - v1
Checksum:i226F389FB08B94C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378674 Genomic DNA. Translation: CAG21735.1.
RefSeqiWP_011219976.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG21735; CAG21735; PBPRA3464.
KEGGippr:PBPRA3464.
PATRICi22938011. VBIPhoPro109272_3588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378674 Genomic DNA. Translation: CAG21735.1.
RefSeqiWP_011219976.1. NC_006370.1.

3D structure databases

ProteinModelPortaliQ6LLU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi298386.PBPRA3464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG21735; CAG21735; PBPRA3464.
KEGGippr:PBPRA3464.
PATRICi22938011. VBIPhoPro109272_3588.

Phylogenomic databases

eggNOGiENOG4105CHI. Bacteria.
COG4206. LUCA.
HOGENOMiHOG000269547.
KOiK16092.
OMAiGHWAVNA.
OrthoDBiEOG68H83J.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
HAMAPiMF_01531. BtuB.
InterProiIPR010101. B12_transptr_BtuB.
IPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1253 / SS9.

Entry informationi

Entry nameiBTUB_PHOPR
AccessioniPrimary (citable) accession number: Q6LLU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.