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Protein

Vitamin B12 transporter BtuB

Gene

btuB

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin B12 transporter BtuBUniRule annotation
Alternative name(s):
Cobalamin receptorUniRule annotation
Outer membrane cobalamin translocatorUniRule annotation
Gene namesi
Name:btuBUniRule annotation
Ordered Locus Names:PBPRA3464
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

Subcellular locationi

  • Cell outer membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_000000348522 – 606Vitamin B12 transporter BtuBAdd BLAST585

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA3464

Structurei

3D structure databases

ProteinModelPortaliQ6LLU3
SMRiQ6LLU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi28 – 35TonB box8
Motifi589 – 606TonB C-terminal boxAdd BLAST18

Sequence similaritiesi

Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. [View classification]UniRule annotation

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CHI Bacteria
COG4206 LUCA
HOGENOMiHOG000269547
KOiK16092
OMAiGHWAVNA
OrthoDBiPOG091H01EB

Family and domain databases

Gene3Di2.170.130.10, 1 hit
2.40.170.20, 1 hit
HAMAPiMF_01531 BtuB, 1 hit
InterProiView protein in InterPro
IPR010101 B12_transptr_BtuB
IPR012910 Plug_dom
IPR037066 Plug_dom_sf
IPR000531 TonB-dep_rcpt_b-brl
IPR036942 TonB_rcpt_b-brl_sf
PfamiView protein in Pfam
PF07715 Plug, 1 hit
PF00593 TonB_dep_Rec, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6LLU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTLLAVAL APLCLPSQVF AADESSNDVM VVTANRFEQP IKNVIAPISV
60 70 80 90 100
VTKEEIDAIQ AKSIAEVLRR LPGVQVVSGG YGQATEVYVR GTTSRHLLVM
110 120 130 140 150
INGVRIGSAT LGSADFSQIP LTGIERIELI RGSRAALYGS DAIGGVLNII
160 170 180 190 200
TAYQPGESVA EVTAGGGSDG FYQLGGSVAG GLGESGWGKI ALKTEGADGF
210 220 230 240 250
SARKEPFEQD DDGFKNSNVV AEVGTHVGDH WKLSLQGYYH DGESDYDDSY
260 270 280 290 300
GAPHAQSESS LFNIAAKAGY SNDKLDSQFT VAQNQDENRN FNDVSSGSKI
310 320 330 340 350
KTERTVANWQ NHYQLTDGLE LGGGLEWYRD SVSNTGTQYA EDERDNTAVY
360 370 380 390 400
LTSIYRISDW QFEGSVRTDD NDSYGTNNTW QLATAYNITS ELKVSANAGT
410 420 430 440 450
GFKAPTFNDL YWPDSGNPNL KPEESKNYEI SLSGTHQLLD WSITGYQSEI
460 470 480 490 500
DQLIAWAPKD ASNPSGDWIP MNVDEAEIQG IELTAGFATG MLYHDVSYDY
510 520 530 540 550
LDAKDKGLDK QLIRRSKDSA KWNVSYLAEQ WQLDVSAIYK GTSYDDAANT
560 570 580 590 600
KKLDAYTLVD IAASYFVTDN LSVRGRIANL FDKDYVAKET YNVQERSYYA

TATYKF
Length:606
Mass (Da):66,298
Last modified:July 5, 2004 - v1
Checksum:i226F389FB08B94C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378674 Genomic DNA Translation: CAG21735.1
RefSeqiWP_011219976.1, NC_006370.1

Genome annotation databases

EnsemblBacteriaiCAG21735; CAG21735; PBPRA3464
KEGGippr:PBPRA3464

Similar proteinsi

Entry informationi

Entry nameiBTUB_PHOPR
AccessioniPrimary (citable) accession number: Q6LLU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health