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Q6LLT9 (STHA_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Soluble pyridine nucleotide transhydrogenase
Short name=STH
EC=1.6.1.1
Alternative name(s):
NAD(P)(+) transhydrogenase [B-specific]
Gene names
Name:sthA
Ordered Locus Names:PBPRA3468
OrganismPhotobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]
Taxonomic identifier74109 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247

Catalytic activity

NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247

Cofactor

Binds 1 FAD per subunit By similarity. HAMAP MF_00247

Subcellular location

Cytoplasm By similarity HAMAP MF_00247.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
NAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD(P)+ transhydrogenase (B-specific) activity

Inferred from electronic annotation. Source: EC

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247
PRO_0000260237

Regions

Nucleotide binding39 – 4810FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LLT9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5C5FD40A03B33165

FASTA46951,528
        10         20         30         40         50         60 
MTKNKKPTHF DAIIIGSGPG GEGAAMGLTK AGLNVAVIER ENSVGGGCTH WGTIPSKALR 

        70         80         90        100        110        120 
HAVSRIIEYN QNPLYCKNNS SLHSTFSQIL GHAQDVVNKQ TRMRQGFYDR NKCSLIFGEA 

       130        140        150        160        170        180 
SFIDAHTVRV KNADNSTDLY SADKFVIATG SRPYHPEGVD FDHSRVYDSD SILQLEHDPR 

       190        200        210        220        230        240 
HIIIYGAGVI GSEYASIFRG LGVKVDLINT RHRLLEFLDN EISDSLSYHL WNSGAMIRNG 

       250        260        270        280        290        300 
ETFEKIEGTD DSIILHLESG KKMRADCLLY ANGRTGNTDK LNLNKVGLTP DSRGQLAVNQ 

       310        320        330        340        350        360 
NYCTDVDHVY AVGDVIGYPS LASAAYDQGR FVAQAITTGE AQGSLIDHIP TGIYTIPEIS 

       370        380        390        400        410        420 
SVGKTEQQLT ADKVPYEVGR SQFKHLARAQ IAGTEVGSLK ILFHRETKEI LGIHCFGERA 

       430        440        450        460 
AEIIHIGQAI MEQKGDGNTI DYFVNTTFNY PTMAEAYRVA ALNGLNRLF

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References

[1]"Life at depth: Photobacterium profundum genome sequence and expression analysis."
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.
Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR378674 Genomic DNA. Translation: CAG21739.1.
RefSeqYP_131541.1. NC_006370.1.

3D structure databases

HSSPHSSP built from PDB template 2F5Z based on UniProtKB P09622.
ProteinModelPortalQ6LLT9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3122142.
GenomeReviewsGene locus PBPRA3468 in contig CR354531_GR.
KEGGppr:PBPRA3468.
NMPDRfig|298386.1.peg.5653.
PATRIC22938019. VBIPhoPro109272_3592.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG515043.
PhylomeDBQ6LLT9.
ProtClustDBPRK05249.

Enzyme and pathway databases

BioCycPPRO298386:PBPRA3468-MONOMER.

Family and domain databases

HAMAPMF_00247. SthA.
[Tree]
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR022962. STH.
[Graphical view]
Gene3DG3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
KOK00322.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSTHA_PHOPR
AccessionPrimary (citable) accession number: Q6LLT9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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