Reviewed, UniProtKB/Swiss-Prot Q6LLT9 (STHA_PHOPR)

Names and origin

Protein names

Recommended name:
    Soluble pyridine nucleotide transhydrogenase
      Short name=STH
    EC=1.6.1.1
Alternative name(s):
    NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Ordered Locus Names:	PBPRA3468

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity.
Catalytic activity	NADPH + NAD(+) = NADP(+) + NADH. HAMAP MF_00247
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247		PRO_0000260237
Regions
	Nucleotide binding	39 – 48	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LLT9-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 5C5FD40A03B33165	FASTA	469	51,528
	10 20 30 40 50 60 MTKNKKPTHF DAIIIGSGPG GEGAAMGLTK AGLNVAVIER ENSVGGGCTH WGTIPSKALR 70 80 90 100 110 120 HAVSRIIEYN QNPLYCKNNS SLHSTFSQIL GHAQDVVNKQ TRMRQGFYDR NKCSLIFGEA 130 140 150 160 170 180 SFIDAHTVRV KNADNSTDLY SADKFVIATG SRPYHPEGVD FDHSRVYDSD SILQLEHDPR 190 200 210 220 230 240 HIIIYGAGVI GSEYASIFRG LGVKVDLINT RHRLLEFLDN EISDSLSYHL WNSGAMIRNG 250 260 270 280 290 300 ETFEKIEGTD DSIILHLESG KKMRADCLLY ANGRTGNTDK LNLNKVGLTP DSRGQLAVNQ 310 320 330 340 350 360 NYCTDVDHVY AVGDVIGYPS LASAAYDQGR FVAQAITTGE AQGSLIDHIP TGIYTIPEIS 370 380 390 400 410 420 SVGKTEQQLT ADKVPYEVGR SQFKHLARAQ IAGTEVGSLK ILFHRETKEI LGIHCFGERA 430 440 450 460 AEIIHIGQAI MEQKGDGNTI DYFVNTTFNY PTMAEAYRVA ALNGLNRLF

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR378674 Genomic DNA. Translation: CAG21739.1.
RefSeq	YP_131541.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3122142.
GenomeReviews	Gene locus PBPRA3468 in contig CR354531_GR.
KEGG	ppr:PBPRA3468.
NMPDR	fig|298386.1.peg.5653.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6LLT9.
Enzyme and pathway databases
BioCyc	PPRO298386:PBPRA3468-MON.
Family and domain databases
HAMAP	MF_00247. [Tree]
InterPro	IPR000759. Adrndx_reductase. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR001100. Pyr_nuc-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00419. ADXRDTASE. PR00368. FADPNR. PR00945. HGRDTASE. PR00411. PNDRDTASEI.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

STHA_PHOPR

Accession

Primary (citable) accession number: Q6LLT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	July 5, 2004
Last modified:	December 16, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)