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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi: ppGpp biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00908; UER00885

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:PBPRA3543
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942831 – 497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseAdd BLAST497

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA3543

Structurei

3D structure databases

ProteinModelPortaliQ6LLL4
SMRiQ6LLL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9X Bacteria
COG0248 LUCA
HOGENOMiHOG000258672
KOiK01524
OMAiWQICVGA
OrthoDBiPOG091H00D6

Family and domain databases

HAMAPiMF_01550 GppA, 1 hit
InterProiView protein in InterPro
IPR023709 Guo-5TP_3DP_PyrP
IPR003695 Ppx_GppA
IPR030673 PyroPPase_GppA_Ppx
PfamiView protein in Pfam
PF02541 Ppx-GppA, 1 hit
PIRSFiPIRSF001267 Pyrophosphatase_GppA_Ppx, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LLL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNPISPLY AAIDLGSNSF HMWIVREVAG SVQTLAKIKR KVRLAAGLNS
60 70 80 90 100
QNELSEEAMQ RGWDCLSLFA ERLQDIPAER VRIIGTAALR TAVNADIFLS
110 120 130 140 150
KAKDILGSKV DVIPGEEEAR IIYQGVAHTS GGSDKRLVVD IGGASTEVII
160 170 180 190 200
GEGFDASALT SLKIGCVTWL ERYFKDRYLT AENFDAAIDA AKNAIEPIVE
210 220 230 240 250
QYTQLGWETC VGASGTVQAL QEIMLAQGMD EIITLSKLKR MQRQAMQYER
260 270 280 290 300
LEDLDIEGLT LERALVFPSG LSILIAVFES LNIESMTLAG GALREGMVYE
310 320 330 340 350
MMSKMRHHDV RERTLTSVQE RFQLDTSHAS AVTNTAMALL SRCDEEWQLE
360 370 380 390 400
PQAQYLLHAS VCLHEIGTSI EFKKSGEHAA YLINHIDLPG FTRAQKHLIA
410 420 430 440 450
ELLRRFREQL TSLPEQHALS AQNAARILRL LRLAVILCHR RDHNQQPPFS
460 470 480 490
LSVAENKLVL TLPAAWLLAN PLSHVELQQE ATRQTDMGWP LVLEESE
Length:497
Mass (Da):55,419
Last modified:July 5, 2004 - v1
Checksum:iB19477BE5ECF3E99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378674 Genomic DNA Translation: CAG21814.1
RefSeqiWP_011220054.1, NC_006370.1

Genome annotation databases

EnsemblBacteriaiCAG21814; CAG21814; PBPRA3543
KEGGippr:PBPRA3543

Similar proteinsi

Entry informationi

Entry nameiGPPA_PHOPR
AccessioniPrimary (citable) accession number: Q6LLL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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