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Q6LLL4

- GPPA_PHOPR

UniProt

Q6LLL4 - GPPA_PHOPR

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:PBPRA3543
    OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
    Taxonomic identifieri74109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
    ProteomesiUP000000593: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194283Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi298386.PBPRA3543.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LLL4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6LLL4-1 [UniParc]FASTAAdd to Basket

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    MERNPISPLY AAIDLGSNSF HMWIVREVAG SVQTLAKIKR KVRLAAGLNS    50
    QNELSEEAMQ RGWDCLSLFA ERLQDIPAER VRIIGTAALR TAVNADIFLS 100
    KAKDILGSKV DVIPGEEEAR IIYQGVAHTS GGSDKRLVVD IGGASTEVII 150
    GEGFDASALT SLKIGCVTWL ERYFKDRYLT AENFDAAIDA AKNAIEPIVE 200
    QYTQLGWETC VGASGTVQAL QEIMLAQGMD EIITLSKLKR MQRQAMQYER 250
    LEDLDIEGLT LERALVFPSG LSILIAVFES LNIESMTLAG GALREGMVYE 300
    MMSKMRHHDV RERTLTSVQE RFQLDTSHAS AVTNTAMALL SRCDEEWQLE 350
    PQAQYLLHAS VCLHEIGTSI EFKKSGEHAA YLINHIDLPG FTRAQKHLIA 400
    ELLRRFREQL TSLPEQHALS AQNAARILRL LRLAVILCHR RDHNQQPPFS 450
    LSVAENKLVL TLPAAWLLAN PLSHVELQQE ATRQTDMGWP LVLEESE 497
    Length:497
    Mass (Da):55,419
    Last modified:July 5, 2004 - v1
    Checksum:iB19477BE5ECF3E99
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378674 Genomic DNA. Translation: CAG21814.1.
    RefSeqiYP_131616.1. NC_006370.1.

    Genome annotation databases

    EnsemblBacteriaiCAG21814; CAG21814; PBPRA3543.
    GeneIDi3123968.
    KEGGippr:PBPRA3543.
    PATRICi22938181. VBIPhoPro109272_3673.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378674 Genomic DNA. Translation: CAG21814.1 .
    RefSeqi YP_131616.1. NC_006370.1.

    3D structure databases

    ProteinModelPortali Q6LLL4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 298386.PBPRA3543.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG21814 ; CAG21814 ; PBPRA3543 .
    GeneIDi 3123968.
    KEGGi ppr:PBPRA3543.
    PATRICi 22938181. VBIPhoPro109272_3673.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS9.

    Entry informationi

    Entry nameiGPPA_PHOPR
    AccessioniPrimary (citable) accession number: Q6LLL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3