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Q6LLL4

- GPPA_PHOPR

UniProt

Q6LLL4 - GPPA_PHOPR

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene
gppA, PBPRA3543
Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:PBPRA3543
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotationPRO_0000194283Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA3543.

Structurei

3D structure databases

ProteinModelPortaliQ6LLL4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LLL4-1 [UniParc]FASTAAdd to Basket

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MERNPISPLY AAIDLGSNSF HMWIVREVAG SVQTLAKIKR KVRLAAGLNS    50
QNELSEEAMQ RGWDCLSLFA ERLQDIPAER VRIIGTAALR TAVNADIFLS 100
KAKDILGSKV DVIPGEEEAR IIYQGVAHTS GGSDKRLVVD IGGASTEVII 150
GEGFDASALT SLKIGCVTWL ERYFKDRYLT AENFDAAIDA AKNAIEPIVE 200
QYTQLGWETC VGASGTVQAL QEIMLAQGMD EIITLSKLKR MQRQAMQYER 250
LEDLDIEGLT LERALVFPSG LSILIAVFES LNIESMTLAG GALREGMVYE 300
MMSKMRHHDV RERTLTSVQE RFQLDTSHAS AVTNTAMALL SRCDEEWQLE 350
PQAQYLLHAS VCLHEIGTSI EFKKSGEHAA YLINHIDLPG FTRAQKHLIA 400
ELLRRFREQL TSLPEQHALS AQNAARILRL LRLAVILCHR RDHNQQPPFS 450
LSVAENKLVL TLPAAWLLAN PLSHVELQQE ATRQTDMGWP LVLEESE 497
Length:497
Mass (Da):55,419
Last modified:July 5, 2004 - v1
Checksum:iB19477BE5ECF3E99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378674 Genomic DNA. Translation: CAG21814.1.
RefSeqiYP_131616.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG21814; CAG21814; PBPRA3543.
GeneIDi3123968.
KEGGippr:PBPRA3543.
PATRICi22938181. VBIPhoPro109272_3673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378674 Genomic DNA. Translation: CAG21814.1 .
RefSeqi YP_131616.1. NC_006370.1.

3D structure databases

ProteinModelPortali Q6LLL4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA3543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG21814 ; CAG21814 ; PBPRA3543 .
GeneIDi 3123968.
KEGGi ppr:PBPRA3543.
PATRICi 22938181. VBIPhoPro109272_3673.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiGPPA_PHOPR
AccessioniPrimary (citable) accession number: Q6LLL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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