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Q6LLL4

- GPPA_PHOPR

UniProt

Q6LLL4 - GPPA_PHOPR

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:PBPRA3543
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194283Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA3543.

Structurei

3D structure databases

ProteinModelPortaliQ6LLL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LLL4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERNPISPLY AAIDLGSNSF HMWIVREVAG SVQTLAKIKR KVRLAAGLNS
60 70 80 90 100
QNELSEEAMQ RGWDCLSLFA ERLQDIPAER VRIIGTAALR TAVNADIFLS
110 120 130 140 150
KAKDILGSKV DVIPGEEEAR IIYQGVAHTS GGSDKRLVVD IGGASTEVII
160 170 180 190 200
GEGFDASALT SLKIGCVTWL ERYFKDRYLT AENFDAAIDA AKNAIEPIVE
210 220 230 240 250
QYTQLGWETC VGASGTVQAL QEIMLAQGMD EIITLSKLKR MQRQAMQYER
260 270 280 290 300
LEDLDIEGLT LERALVFPSG LSILIAVFES LNIESMTLAG GALREGMVYE
310 320 330 340 350
MMSKMRHHDV RERTLTSVQE RFQLDTSHAS AVTNTAMALL SRCDEEWQLE
360 370 380 390 400
PQAQYLLHAS VCLHEIGTSI EFKKSGEHAA YLINHIDLPG FTRAQKHLIA
410 420 430 440 450
ELLRRFREQL TSLPEQHALS AQNAARILRL LRLAVILCHR RDHNQQPPFS
460 470 480 490
LSVAENKLVL TLPAAWLLAN PLSHVELQQE ATRQTDMGWP LVLEESE
Length:497
Mass (Da):55,419
Last modified:July 5, 2004 - v1
Checksum:iB19477BE5ECF3E99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378674 Genomic DNA. Translation: CAG21814.1.
RefSeqiYP_131616.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG21814; CAG21814; PBPRA3543.
GeneIDi3123968.
KEGGippr:PBPRA3543.
PATRICi22938181. VBIPhoPro109272_3673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378674 Genomic DNA. Translation: CAG21814.1 .
RefSeqi YP_131616.1. NC_006370.1.

3D structure databases

ProteinModelPortali Q6LLL4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA3543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG21814 ; CAG21814 ; PBPRA3543 .
GeneIDi 3123968.
KEGGi ppr:PBPRA3543.
PATRICi 22938181. VBIPhoPro109272_3673.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiGPPA_PHOPR
AccessioniPrimary (citable) accession number: Q6LLL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3