Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6LLL4 (GPPA_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:PBPRA3543
OrganismPhotobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]
Taxonomic identifier74109 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000194283

Sequences

Sequence LengthMass (Da)Tools
Q6LLL4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B19477BE5ECF3E99

FASTA49755,419
        10         20         30         40         50         60 
MERNPISPLY AAIDLGSNSF HMWIVREVAG SVQTLAKIKR KVRLAAGLNS QNELSEEAMQ 

        70         80         90        100        110        120 
RGWDCLSLFA ERLQDIPAER VRIIGTAALR TAVNADIFLS KAKDILGSKV DVIPGEEEAR 

       130        140        150        160        170        180 
IIYQGVAHTS GGSDKRLVVD IGGASTEVII GEGFDASALT SLKIGCVTWL ERYFKDRYLT 

       190        200        210        220        230        240 
AENFDAAIDA AKNAIEPIVE QYTQLGWETC VGASGTVQAL QEIMLAQGMD EIITLSKLKR 

       250        260        270        280        290        300 
MQRQAMQYER LEDLDIEGLT LERALVFPSG LSILIAVFES LNIESMTLAG GALREGMVYE 

       310        320        330        340        350        360 
MMSKMRHHDV RERTLTSVQE RFQLDTSHAS AVTNTAMALL SRCDEEWQLE PQAQYLLHAS 

       370        380        390        400        410        420 
VCLHEIGTSI EFKKSGEHAA YLINHIDLPG FTRAQKHLIA ELLRRFREQL TSLPEQHALS 

       430        440        450        460        470        480 
AQNAARILRL LRLAVILCHR RDHNQQPPFS LSVAENKLVL TLPAAWLLAN PLSHVELQQE 

       490 
ATRQTDMGWP LVLEESE 

« Hide

References

[1]"Life at depth: Photobacterium profundum genome sequence and expression analysis."
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.
Science 307:1459-1461(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR378674 Genomic DNA. Translation: CAG21814.1.
RefSeqYP_131616.1. NC_006370.1.

3D structure databases

ProteinModelPortalQ6LLL4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING298386.PBPRA3543.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG21814; CAG21814; PBPRA3543.
GeneID3123968.
KEGGppr:PBPRA3543.
PATRIC22938181. VBIPhoPro109272_3673.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAPPRVAEH.
OrthoDBEOG6M6JN6.
ProtClustDBPRK11031.

Enzyme and pathway databases

UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_PHOPR
AccessionPrimary (citable) accession number: Q6LLL4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways