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Q6LLH3

- GLMS_PHOPR

UniProt

Q6LLH3 - GLMS_PHOPR

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, PBPRA3599
Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei605 – 6051For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:PBPRA3599
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135366Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA3599.

Structurei

3D structure databases

ProteinModelPortaliQ6LLH3.
SMRiQ6LLH3. Positions 2-610.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2
Add
BLAST
Domaini286 – 426141SIS 1
Add
BLAST
Domaini459 – 600142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6LLH3-1 [UniParc]FASTAAdd to Basket

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MCGIVGAVAQ RDVAEILVEG LRRLEYRGYD SAGVAILDTE CNLQRVRRLG    50
KVKELADAVD SNPIVGGTGI AHTRWATHGE PSEANAHPHV SGDISIVHNG 100
IIENHEYLRA LLQERGYVFE SQTDTEVIAH LVEWELRSAK SLLEAVQKTA 150
AQLEGAYGTV AMNRRDPERL VVARSGSPLV IGLGIGENFL ASDQLALLNV 200
TRRFMFLEEG DVAEITRRDV NIFDVHGNAV EREITESNAE HDAGDKGQYR 250
HFMQKEIFEQ PTALINTMEG RISNDTVIVE SIGAGAADIL RNVEHVQIVA 300
CGTSYNAGMT ARYWFEALAG VSCDVEIASE FRYRKFVTRP NSLLITLSQS 350
GETADTLAAL RLAKEKGYMS AMTICNVAGS SLVRESDLAF MTRAGTEIGV 400
ASTKAFTTQL ATMLMFVTAL GKQKGVINPQ KEKEIVTSLH QLPTQIEKAL 450
AFDKSIEQLA EDFADKHHTL FLGRGEFYPI AMEGSLKLKE ISYIHAEAYA 500
AGELKHGPLA LIDADMPVVV VAPTNELLEK LKSNIEEVRA RGGLLYVFAD 550
EKAGFEPCDG MKIITMPHVS EYTAPIFYTV PMQLLSYHVA LIKGTDVDQP 600
RNLAKAVTVE 610
Length:610
Mass (Da):66,888
Last modified:January 23, 2007 - v3
Checksum:iA755B2D8E50AA45F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378674 Genomic DNA. Translation: CAG21855.1.
RefSeqiYP_131657.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG21855; CAG21855; PBPRA3599.
GeneIDi3124705.
KEGGippr:PBPRA3599.
PATRICi22938297. VBIPhoPro109272_3717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378674 Genomic DNA. Translation: CAG21855.1 .
RefSeqi YP_131657.1. NC_006370.1.

3D structure databases

ProteinModelPortali Q6LLH3.
SMRi Q6LLH3. Positions 2-610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA3599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG21855 ; CAG21855 ; PBPRA3599 .
GeneIDi 3124705.
KEGGi ppr:PBPRA3599.
PATRICi 22938297. VBIPhoPro109272_3717.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiGLMS_PHOPR
AccessioniPrimary (citable) accession number: Q6LLH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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