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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei605For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:PBPRA3599
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353662 – 610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST609

Proteomic databases

PRIDEiQ6LLH3.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA3599.

Structurei

3D structure databases

ProteinModelPortaliQ6LLH3.
SMRiQ6LLH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini286 – 426SIS 1UniRule annotationAdd BLAST141
Domaini459 – 600SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
HOGENOMiHOG000258898.
KOiK00820.
OrthoDBiPOG091H0061.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF15. PTHR10937:SF15. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6LLH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGAVAQ RDVAEILVEG LRRLEYRGYD SAGVAILDTE CNLQRVRRLG
60 70 80 90 100
KVKELADAVD SNPIVGGTGI AHTRWATHGE PSEANAHPHV SGDISIVHNG
110 120 130 140 150
IIENHEYLRA LLQERGYVFE SQTDTEVIAH LVEWELRSAK SLLEAVQKTA
160 170 180 190 200
AQLEGAYGTV AMNRRDPERL VVARSGSPLV IGLGIGENFL ASDQLALLNV
210 220 230 240 250
TRRFMFLEEG DVAEITRRDV NIFDVHGNAV EREITESNAE HDAGDKGQYR
260 270 280 290 300
HFMQKEIFEQ PTALINTMEG RISNDTVIVE SIGAGAADIL RNVEHVQIVA
310 320 330 340 350
CGTSYNAGMT ARYWFEALAG VSCDVEIASE FRYRKFVTRP NSLLITLSQS
360 370 380 390 400
GETADTLAAL RLAKEKGYMS AMTICNVAGS SLVRESDLAF MTRAGTEIGV
410 420 430 440 450
ASTKAFTTQL ATMLMFVTAL GKQKGVINPQ KEKEIVTSLH QLPTQIEKAL
460 470 480 490 500
AFDKSIEQLA EDFADKHHTL FLGRGEFYPI AMEGSLKLKE ISYIHAEAYA
510 520 530 540 550
AGELKHGPLA LIDADMPVVV VAPTNELLEK LKSNIEEVRA RGGLLYVFAD
560 570 580 590 600
EKAGFEPCDG MKIITMPHVS EYTAPIFYTV PMQLLSYHVA LIKGTDVDQP
610
RNLAKAVTVE
Length:610
Mass (Da):66,888
Last modified:January 23, 2007 - v3
Checksum:iA755B2D8E50AA45F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378674 Genomic DNA. Translation: CAG21855.1.
RefSeqiWP_011220091.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG21855; CAG21855; PBPRA3599.
KEGGippr:PBPRA3599.

Similar proteinsi

Entry informationi

Entry nameiGLMS_PHOPR
AccessioniPrimary (citable) accession number: Q6LLH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 95 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome