Reviewed, UniProtKB/Swiss-Prot Q6LLG6 (ATPA1_PHOPR)

Names and origin

Protein names

Recommended name:
    ATP synthase subunit alpha 1
    EC=3.6.3.14
Alternative name(s):
    F-ATPase subunit alpha 1
    ATP synthase F1 sector subunit alpha 1

Gene names

Name:	atpA1
Ordered Locus Names:	PBPRA3606

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity.
Catalytic activity	ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(1) Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW proton-transporting ATP synthase complex, catalytic core F(1) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	ATP synthase subunit alpha 1 HAMAP MF_01346		PRO_0000238318
Regions
	Nucleotide binding	169 – 176	8	ATP By similarity
Sites
	Site	373	1	Required for activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LLG6-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7F3E4CAFF0E84A28	FASTA	513	55,433
	10 20 30 40 50 60 MQLNSTEISA LIKQRIEKFN VASEARNEGT IVSVSDGIIR IHGLADVMQG EMIELPGGRF 70 80 90 100 110 120 ALALNLERDS VGAVVMGPYA NLQEGMKVTG TGRILEVPVG PALLGRVVNT LGEPIDGKGP 130 140 150 160 170 180 IETETFSPVE VIAPGVIERK SVDQPVQTGY KAVDSMIPIG RGQRELIIGD RQTGKTAMAI 190 200 210 220 230 240 DAIINQKQSG IYSVYVAIGQ KASTIANVVR KLEEHGALDN TIVVVASASE AAALQYLAPY 250 260 270 280 290 300 SGCAMGEYFR DRGEDALIVY DDLSKQAVAY RQISLLLKRP PGREAFPGDV FYLHSRLLER 310 320 330 340 350 360 ASRVSENYVE KFTNGEVKGK TGSLTALPII ETQAGDVSAF VPTNVISITD GQIFLQTELF 370 380 390 400 410 420 NAGIRPAVDP GISVSRVGGS AQTKIIKKLS GGIRTALAQY RELAAFAQFS SDLDEATKKQ 430 440 450 460 470 480 LDHGQKVTEL MKQKQYAPMS VFEQAVVIFS AERGYLVDVE LAKLADFEAA LLSYAKGQSA 490 500 510 ELVSQIDETG AWNSEIEAQF VKLVEDFKAT QTW

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR378674 Genomic DNA. Translation: CAG21862.1.
RefSeq	YP_131664.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3124674.
GenomeReviews	Gene locus PBPRA3606 in contig CR354531_GR.
KEGG	ppr:PBPRA3606.
NMPDR	fig|298386.1.peg.5782.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6LLG6.
OMA	RITEETE.
Enzyme and pathway databases
BioCyc	PPRO298386:PBPRA3606-MON.
BRENDA	3.6.3.14. 263915.
Family and domain databases
HAMAP	MF_01346. [Tree]
InterPro	IPR005294. ATPase_F1-cplx_asu. IPR017458. ATPase_F1-cplx_asu_C. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N. IPR020003. ATPase_F1/V1/A1_a/bsu_AS. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. [Graphical view]
PANTHER	PTHR15184:SF3. ATPase_F1_a. 1 hit.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00962. atpA. 1 hit.
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATPA1_PHOPR

Accession

Primary (citable) accession number: Q6LLG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)