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Q6LL68

- BGAL_PHOPR

UniProt

Q6LL68 - BGAL_PHOPR

Protein

Beta-galactosidase

Gene

lacZ

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per monomer.UniRule annotation
    Binds 1 sodium ion per monomer.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991SubstrateUniRule annotation
    Metal bindingi197 – 1971SodiumUniRule annotation
    Binding sitei197 – 1971SubstrateUniRule annotation
    Sitei352 – 3521Transition state stabilizerUniRule annotation
    Sitei386 – 3861Transition state stabilizerUniRule annotation
    Metal bindingi411 – 4111Magnesium 1UniRule annotation
    Metal bindingi413 – 4131Magnesium 1UniRule annotation
    Active sitei456 – 4561Proton donorUniRule annotation
    Metal bindingi456 – 4561Magnesium 1UniRule annotation
    Binding sitei456 – 4561SubstrateUniRule annotation
    Active sitei532 – 5321NucleophileUniRule annotation
    Metal bindingi592 – 5921Magnesium 2UniRule annotation
    Metal bindingi596 – 5961Sodium; via carbonyl oxygenUniRule annotation
    Metal bindingi599 – 5991SodiumUniRule annotation
    Binding sitei599 – 5991SubstrateUniRule annotation
    Binding sitei1004 – 10041SubstrateUniRule annotation

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
    Short name:
    Beta-galUniRule annotation
    Alternative name(s):
    LactaseUniRule annotation
    Gene namesi
    Name:lacZUniRule annotation
    Ordered Locus Names:PBPRB0034
    OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
    Taxonomic identifieri74109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
    ProteomesiUP000000593: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. beta-galactosidase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10301030Beta-galactosidasePRO_0000367005Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi298386.PBPRB0034.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LL68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni532 – 5354Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000252443.
    KOiK01190.
    OMAiNPPFVPK.
    OrthoDBiEOG6XWV0T.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPiMF_01687. Beta_gal.
    InterProiIPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023933. Glyco_hydro_2_beta_Galsidase.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00132. GLHYDRLASE2.
    SMARTiSM01038. Bgal_small_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6LL68-1 [UniParc]FASTAAdd to Basket

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    MALSDIIQRR DWENPQSVNI HCLKAHSPLA SYRDINHARD GIHAQRQSLN     50
    GQWKFKLFDA PEQVEGEFID VQFNDSAWGD ITVPSNWQLQ GYDKPIYANV 100
    KYPFEVNPPY VPADNPTGCY RTRLTLTEAD LESTQRIIFD GVNSAFHLWC 150
    NGDWVGYSQD SRLPAEFDLS QYLTAGENTL AVMVIRWSDG SYLEDQDMWW 200
    LSGIFRDVTL LSKPKQCIED VFITPDLDAC YRDGSLSIVT HISAPETSQV 250
    HVQLFDGSQA VTEPSIARPH NRRIDERGSY DDVVFQTLHV REPQQWTAET 300
    PNLYRVVVSL LDAEGNHLES EAYQVGFRKV EVKDGQLQLN GKPLLIRGVN 350
    RHEHHPELGH VMTEEDMVRD ICLMKQYNFN AVRTAHYPNH PRWYELCDQY 400
    GLYVCDEANI ETHGMIPMNR LSADPQWAHA YMSRYTQMVM RDKNHPSIII 450
    WSLGNESGHG SSHNAMYAWS KQFDPSRPVQ YEGGGANTTA TDIICPMYAR 500
    VNTTVEDEAV PKWPIKQWIS LPNEQRPLIL CEYAHAMGNS LGNFNEYWDA 550
    FREFPRLQGG FIWDWVDQGL SQWDNDGKHF WAYGGDFGDT INDRQFCING 600
    LIFPDRTPHP TLEEVKFCQR MITVALTQQD KQQCHLTVTN EYVFRSTDNE 650
    QLHWSVLENG VEVQSGQCTL AIDAGSQQTV DIALDFQPKA DAKYHLNTDI 700
    CLISATPWAQ AGHVSATEQF TLSNTSSLTL PKISILSAPQ LSEQGRDILV 750
    SNLDKKHQWQ WNVESGLLTS WMVDGQSQLL HAPEDNFFRA PLDNDIGVSE 800
    IDNIDPNAWV CRWDAAGIGR WERECVSCTS ESLSQAVKVT STFAYHHNGG 850
    VQAITVWTYT LDNQGEMHID VDVTLADHLP PMPRIGLELA LPLPSDNTTV 900
    TWQGLGPFEN YPDRLAAARF GQHTQSLDAM HTPYIFPTDS GLRSGTQWLN 950
    VGNLECTGDF LFSVSRFSQQ QLTEAKHTNE LTLEDKIYLR IDHQHMGVGG 1000
    DDSWSPSVHE EFQLTDNTYR FSIMLKPRHN 1030
    Length:1,030
    Mass (Da):117,266
    Last modified:July 5, 2004 - v1
    Checksum:i6A859CAEA1AF7939
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378675 Genomic DNA. Translation: CAG21907.1.
    RefSeqiYP_131707.1. NC_006371.1.

    Genome annotation databases

    EnsemblBacteriaiCAG21907; CAG21907; PBPRB0034.
    GeneIDi3120206.
    KEGGippr:PBPRB0034.
    PATRICi22938410. VBIPhoPro109272_3773.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378675 Genomic DNA. Translation: CAG21907.1 .
    RefSeqi YP_131707.1. NC_006371.1.

    3D structure databases

    ProteinModelPortali Q6LL68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 298386.PBPRB0034.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG21907 ; CAG21907 ; PBPRB0034 .
    GeneIDi 3120206.
    KEGGi ppr:PBPRB0034.
    PATRICi 22938410. VBIPhoPro109272_3773.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000252443.
    KOi K01190.
    OMAi NPPFVPK.
    OrthoDBi EOG6XWV0T.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPi MF_01687. Beta_gal.
    InterProi IPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023933. Glyco_hydro_2_beta_Galsidase.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00132. GLHYDRLASE2.
    SMARTi SM01038. Bgal_small_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS9.

    Entry informationi

    Entry nameiBGAL_PHOPR
    AccessioniPrimary (citable) accession number: Q6LL68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3