Reviewed, UniProtKB/Swiss-Prot Q6LKE5 (MTLD_PHOPR)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	PBPRB0362

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Mannitol-1-phosphate 5-dehydrogenase		PRO_1000071710
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LKE5-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 60E94E8F8ECDF0BF	FASTA	381	42,223
	10 20 30 40 50 60 MKAVHFGAGN IGRGFIGKLL SDANVAVTFA DIDKPLVDQL SHDQSYKVKV VGSQCQVDTV 70 80 90 100 110 120 THVTAVNSAS QDVIDRIVHT DLVTTAVGPN VLDIIAKTIA TGLAQRFEAN NEKSLNIIAC 130 140 150 160 170 180 ENMVRGTTHL KNEVYKHLDE QYHARADALV GFVDSAVDRI VPPSEAANDP LEVTVESFSE 190 200 210 220 230 240 WIVDKQQFKG DIPVIEGMEM TDNLMAFVER KLFTLNTGHI MTAYLGALKG HETVRDAIED 250 260 270 280 290 300 NEIREQVKAA MQESGEVLIK RYGFDREVHN AYIEKILGRF ANPYLRDEID RVGRQPIRKL 310 320 330 340 350 360 GENDRLIKPL LGTIEYGTEN KTLLKGIAAA FMYTNESDPQ AVELQTSLKE QGLRPTLAHY 370 380 TGIDADSKEA KTIETIFLQL S

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR378676 Genomic DNA. Translation: CAG22235.1.
RefSeq	YP_132035.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3120018.
GenomeReviews	Gene locus PBPRB0362 in contig CR354532_GR.
KEGG	ppr:PBPRB0362.
NMPDR	fig|298386.1.peg.383.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6LKE5.
Enzyme and pathway databases
BioCyc	PPRO298386:PBPRB0362-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_PHOPR

Accession

Primary (citable) accession number: Q6LKE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)