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Q6LJ30 (NAGZ_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:nagZ
Ordered Locus Names:PBPRB0828
OrganismPhotobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]
Taxonomic identifier74109 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity. HAMAP-Rule MF_00364

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00364.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Beta-hexosaminidase HAMAP-Rule MF_00364
PRO_0000234920

Regions

Region160 – 1612Substrate binding By similarity

Sites

Active site1731Proton donor/acceptor By similarity
Active site2431Nucleophile By similarity
Binding site621Substrate By similarity
Binding site701Substrate By similarity
Binding site1301Substrate By similarity
Site1711Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LJ30 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 73B940AEDED051E2

FASTA33437,533
        10         20         30         40         50         60 
MGPLMLDVLG YELNAEEREI IQHPTVGGII FFARNYHDRA QLRALTKDIR KTAAKPLLIA 

        70         80         90        100        110        120 
VDQEGGRVQR FREEFTQLPP ARAFEQHNNG IELAKKGGWL MAAELLAMDI DLSLAPVLDL 

       130        140        150        160        170        180 
GFDCKAIGDR AFSDDPKKII KYASQFIKGM KQAGMATTGK HFPGHGGVIA DSHLETPFDS 

       190        200        210        220        230        240 
RENIKEHDMI VFKYLIENNL LDAMMPAHVV FDAYDDKPAS GSDYWLKQVL RQDLHFKGVI 

       250        260        270        280        290        300 
FSDDLNMKGA DVMGSYSERA IAAQQAGCDM VMLCNNREGA IQALDGLPQV NVPILDTLLK 

       310        320        330 
RPTGEYQELI KTSMWKETEK EISRLSLEWR EKHS 

« Hide

References

[1]"Life at depth: Photobacterium profundum genome sequence and expression analysis."
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.
Science 307:1459-1461(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR378677 Genomic DNA. Translation: CAG22700.1.
RefSeqYP_132500.1. NC_006371.1.

3D structure databases

ProteinModelPortalQ6LJ30.
SMRQ6LJ30. Positions 1-333.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING298386.PBPRB0828.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG22700; CAG22700; PBPRB0828.
GeneID3120865.
KEGGppr:PBPRB0828.
PATRIC22940149. VBIPhoPro109272_4641.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000248526.
KOK01207.
OMAAGFSSYW.
OrthoDBEOG6BCT06.
ProtClustDBPRK05337.

Enzyme and pathway databases

UniPathwayUPA00544.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
HAMAPMF_00364. NagZ.
InterProIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGZ_PHOPR
AccessionPrimary (citable) accession number: Q6LJ30
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries