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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62SubstrateUniRule annotation1
Binding sitei70SubstrateUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Sitei171Important for catalytic activityUniRule annotation1
Active sitei173Proton donor/acceptorUniRule annotation1
Active sitei243NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00544

Protein family/group databases

CAZyiGH3 Glycoside Hydrolase Family 3

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:PBPRB0828
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002349201 – 334Beta-hexosaminidaseAdd BLAST334

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRB0828

Structurei

3D structure databases

ProteinModelPortaliQ6LJ30
SMRiQ6LJ30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni160 – 161Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPA Bacteria
COG1472 LUCA
HOGENOMiHOG000248526
KOiK01207
OMAiHKETPRD
OrthoDBiPOG091H039J

Family and domain databases

Gene3Di3.20.20.3001 hit
HAMAPiMF_00364 NagZ, 1 hit
InterProiView protein in InterPro
IPR022956 Beta_hexosaminidase_bac
IPR019800 Glyco_hydro_3_AS
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00933 Glyco_hydro_3, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00775 GLYCOSYL_HYDROL_F3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LJ30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLMLDVLG YELNAEEREI IQHPTVGGII FFARNYHDRA QLRALTKDIR
60 70 80 90 100
KTAAKPLLIA VDQEGGRVQR FREEFTQLPP ARAFEQHNNG IELAKKGGWL
110 120 130 140 150
MAAELLAMDI DLSLAPVLDL GFDCKAIGDR AFSDDPKKII KYASQFIKGM
160 170 180 190 200
KQAGMATTGK HFPGHGGVIA DSHLETPFDS RENIKEHDMI VFKYLIENNL
210 220 230 240 250
LDAMMPAHVV FDAYDDKPAS GSDYWLKQVL RQDLHFKGVI FSDDLNMKGA
260 270 280 290 300
DVMGSYSERA IAAQQAGCDM VMLCNNREGA IQALDGLPQV NVPILDTLLK
310 320 330
RPTGEYQELI KTSMWKETEK EISRLSLEWR EKHS
Length:334
Mass (Da):37,533
Last modified:July 5, 2004 - v1
Checksum:i73B940AEDED051E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378677 Genomic DNA Translation: CAG22700.1
RefSeqiWP_011220909.1, NC_006371.1

Genome annotation databases

EnsemblBacteriaiCAG22700; CAG22700; PBPRB0828
KEGGippr:PBPRB0828

Similar proteinsi

Entry informationi

Entry nameiNAGZ_PHOPR
AccessioniPrimary (citable) accession number: Q6LJ30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome