Q6LJ30 (NAGZ_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-hexosaminidase
EC=3.2.1.52

Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	PBPRB0828

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity. HAMAP-Rule MF_00364
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Beta-hexosaminidase HAMAP-Rule MF_00364		PRO_0000234920
Sites
	Active site	243	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LJ30 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 73B940AEDED051E2	FASTA	334	37,533
	10 20 30 40 50 60 MGPLMLDVLG YELNAEEREI IQHPTVGGII FFARNYHDRA QLRALTKDIR KTAAKPLLIA 70 80 90 100 110 120 VDQEGGRVQR FREEFTQLPP ARAFEQHNNG IELAKKGGWL MAAELLAMDI DLSLAPVLDL 130 140 150 160 170 180 GFDCKAIGDR AFSDDPKKII KYASQFIKGM KQAGMATTGK HFPGHGGVIA DSHLETPFDS 190 200 210 220 230 240 RENIKEHDMI VFKYLIENNL LDAMMPAHVV FDAYDDKPAS GSDYWLKQVL RQDLHFKGVI 250 260 270 280 290 300 FSDDLNMKGA DVMGSYSERA IAAQQAGCDM VMLCNNREGA IQALDGLPQV NVPILDTLLK 310 320 330 RPTGEYQELI KTSMWKETEK EISRLSLEWR EKHS

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SS9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR378677 Genomic DNA. Translation: CAG22700.1.
RefSeq	YP_132500.1. NC_006371.1.
3D structure databases
ProteinModelPortal	Q6LJ30.
SMR	Q6LJ30. Positions 1-333.
ModBase	Search...
Protein-protein interaction databases
STRING	298386.PBPRB0828.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG22700; CAG22700; PBPRB0828.
GeneID	3120865.
KEGG	ppr:PBPRB0828.
PATRIC	22940149. VBIPhoPro109272_4641.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1472.
HOGENOM	HOG000248526.
KO	K01207.
OMA	VVLHCNG.
ProtClustDB	PRK05337.
Enzyme and pathway databases
UniPathway	UPA00544.
Family and domain databases
Gene3D	3.20.20.300. 1 hit.
HAMAP	MF_00364. NagZ.
InterPro	IPR022956. Beta_hexosaminidase_bac. IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_PHOPR

Accession

Primary (citable) accession number: Q6LJ30

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program