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Q6LHN5 (GCSP_PHOPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:PBPRB1324
OrganismPhotobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]
Taxonomic identifier74109 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Protein attributes

Sequence length959 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 959959Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227112

Amino acid modifications

Modified residue7071N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LHN5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3155DFA0FF368910

FASTA959104,908
        10         20         30         40         50         60 
MTDMTLLNAL SDDQDFAGRH NGPNAAQQNI MLKAISAESV EQLIAQTVPA DIRLPEPMKL 

        70         80         90        100        110        120 
DPAQSEADML TSLKAIASKN IINRSYIGQG YYNNLTPNVV LRNVLENPGW YTAYTPYQPE 

       130        140        150        160        170        180 
ISQGRLESLL NYQQMIMDLT SMELANASLL DEATAAAEAM TLCLRAGKSK SKAFFVSNDL 

       190        200        210        220        230        240 
HPQTVDVVRT RAEYIGIEII TGSVEELDNH DVFGALVQYP GTTGSITDLT DIIEKAHAKK 

       250        260        270        280        290        300 
TLVAVASDLL ALTLLKAPGE MGADVVIGSA QRFGVPMGFG GPHAGFMATK DKHKRTMPGR 

       310        320        330        340        350        360 
VIGVSKDARG NQSLRMAMQT REQHIRREKA TSNICTAQAL LANMAAFYAL YHGPEGLRKI 

       370        380        390        400        410        420 
GRRVHHLTAI LAAGLRNSGI ELASDTFFDT ITLNTGKKTD DFYKKALAAG INLRKFDVQL 

       430        440        450        460        470        480 
GISLDETTKV SDVEELLAIF TGNKLKASMF TADIAADEFA AIPESCRRTS KYLTHPVFNE 

       490        500        510        520        530        540 
HHSETQMMRY MKKLENKDYS LTHGMIPLGS CTMKLNAAAE MIPITWPEFG SLHPFAPADQ 

       550        560        570        580        590        600 
TKGYQELASK LSEMLCSVTG YDAFSLQPNS GAQGEYAGLI AIQRYHQHNG DSHRNVCLIP 

       610        620        630        640        650        660 
SSAHGTNPAS AAMVSMKVVV VGCDEKGNVD VEDLKVKIEK HRDNLSCIMI TYPSTHGVYE 

       670        680        690        700        710        720 
EAVREVCDLV HDAGGQVYLD GANMNAQVGL TNPGFIGSDV SHLNLHKTFC IPHGGGGPGM 

       730        740        750        760        770        780 
GPIGVKSHLA PFLPGHVQST SDEGQQYAVS AAELGSASIL PISYAYIAMM GEEGLTEATK 

       790        800        810        820        830        840 
LAILNANYVM ERLRPHYPVL YRGTEGRIAH ECIIDIRPLK EASGISEEDV AKRLMDYGFH 

       850        860        870        880        890        900 
APTMSFPVAG TLMIEPTESE DLAELDRFCD AMIAIRQEIA RVQEGEWPID DNPLVHAPHT 

       910        920        930        940        950 
QADLMETEWN RAYSREIACF PTDHTRASKY WPTVNRVDNV FGDRNLICSC PSIDSYIED 

« Hide

References

[1]"Life at depth: Photobacterium profundum genome sequence and expression analysis."
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.
Science 307:1459-1461(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR378679 Genomic DNA. Translation: CAG23195.1.
RefSeqYP_132995.1. NC_006371.1.

3D structure databases

ProteinModelPortalQ6LHN5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING298386.PBPRB1324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG23195; CAG23195; PBPRB1324.
GeneID3121484.
KEGGppr:PBPRB1324.
PATRIC22941270. VBIPhoPro109272_5201.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PHOPR
AccessionPrimary (citable) accession number: Q6LHN5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families