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Q6LHN5

- GCSP_PHOPR

UniProt

Q6LHN5 - GCSP_PHOPR

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PBPRB1324
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Glycine dehydrogenase (decarboxylating)PRO_0000227112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRB1324.

Structurei

3D structure databases

ProteinModelPortaliQ6LHN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LHN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDMTLLNAL SDDQDFAGRH NGPNAAQQNI MLKAISAESV EQLIAQTVPA
60 70 80 90 100
DIRLPEPMKL DPAQSEADML TSLKAIASKN IINRSYIGQG YYNNLTPNVV
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE ISQGRLESLL NYQQMIMDLT SMELANASLL
160 170 180 190 200
DEATAAAEAM TLCLRAGKSK SKAFFVSNDL HPQTVDVVRT RAEYIGIEII
210 220 230 240 250
TGSVEELDNH DVFGALVQYP GTTGSITDLT DIIEKAHAKK TLVAVASDLL
260 270 280 290 300
ALTLLKAPGE MGADVVIGSA QRFGVPMGFG GPHAGFMATK DKHKRTMPGR
310 320 330 340 350
VIGVSKDARG NQSLRMAMQT REQHIRREKA TSNICTAQAL LANMAAFYAL
360 370 380 390 400
YHGPEGLRKI GRRVHHLTAI LAAGLRNSGI ELASDTFFDT ITLNTGKKTD
410 420 430 440 450
DFYKKALAAG INLRKFDVQL GISLDETTKV SDVEELLAIF TGNKLKASMF
460 470 480 490 500
TADIAADEFA AIPESCRRTS KYLTHPVFNE HHSETQMMRY MKKLENKDYS
510 520 530 540 550
LTHGMIPLGS CTMKLNAAAE MIPITWPEFG SLHPFAPADQ TKGYQELASK
560 570 580 590 600
LSEMLCSVTG YDAFSLQPNS GAQGEYAGLI AIQRYHQHNG DSHRNVCLIP
610 620 630 640 650
SSAHGTNPAS AAMVSMKVVV VGCDEKGNVD VEDLKVKIEK HRDNLSCIMI
660 670 680 690 700
TYPSTHGVYE EAVREVCDLV HDAGGQVYLD GANMNAQVGL TNPGFIGSDV
710 720 730 740 750
SHLNLHKTFC IPHGGGGPGM GPIGVKSHLA PFLPGHVQST SDEGQQYAVS
760 770 780 790 800
AAELGSASIL PISYAYIAMM GEEGLTEATK LAILNANYVM ERLRPHYPVL
810 820 830 840 850
YRGTEGRIAH ECIIDIRPLK EASGISEEDV AKRLMDYGFH APTMSFPVAG
860 870 880 890 900
TLMIEPTESE DLAELDRFCD AMIAIRQEIA RVQEGEWPID DNPLVHAPHT
910 920 930 940 950
QADLMETEWN RAYSREIACF PTDHTRASKY WPTVNRVDNV FGDRNLICSC

PSIDSYIED
Length:959
Mass (Da):104,908
Last modified:July 5, 2004 - v1
Checksum:i3155DFA0FF368910
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378679 Genomic DNA. Translation: CAG23195.1.
RefSeqiYP_132995.1. NC_006371.1.

Genome annotation databases

EnsemblBacteriaiCAG23195; CAG23195; PBPRB1324.
GeneIDi3121484.
KEGGippr:PBPRB1324.
PATRICi22941270. VBIPhoPro109272_5201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378679 Genomic DNA. Translation: CAG23195.1 .
RefSeqi YP_132995.1. NC_006371.1.

3D structure databases

ProteinModelPortali Q6LHN5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRB1324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG23195 ; CAG23195 ; PBPRB1324 .
GeneIDi 3121484.
KEGGi ppr:PBPRB1324.
PATRICi 22941270. VBIPhoPro109272_5201.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiGCSP_PHOPR
AccessioniPrimary (citable) accession number: Q6LHN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3