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Q6LHN5

- GCSP_PHOPR

UniProt

Q6LHN5 - GCSP_PHOPR

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:PBPRB1324
    OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
    Taxonomic identifieri74109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
    ProteomesiUP000000593: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 959959Glycine dehydrogenase (decarboxylating)PRO_0000227112Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi298386.PBPRB1324.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LHN5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6LHN5-1 [UniParc]FASTAAdd to Basket

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    MTDMTLLNAL SDDQDFAGRH NGPNAAQQNI MLKAISAESV EQLIAQTVPA    50
    DIRLPEPMKL DPAQSEADML TSLKAIASKN IINRSYIGQG YYNNLTPNVV 100
    LRNVLENPGW YTAYTPYQPE ISQGRLESLL NYQQMIMDLT SMELANASLL 150
    DEATAAAEAM TLCLRAGKSK SKAFFVSNDL HPQTVDVVRT RAEYIGIEII 200
    TGSVEELDNH DVFGALVQYP GTTGSITDLT DIIEKAHAKK TLVAVASDLL 250
    ALTLLKAPGE MGADVVIGSA QRFGVPMGFG GPHAGFMATK DKHKRTMPGR 300
    VIGVSKDARG NQSLRMAMQT REQHIRREKA TSNICTAQAL LANMAAFYAL 350
    YHGPEGLRKI GRRVHHLTAI LAAGLRNSGI ELASDTFFDT ITLNTGKKTD 400
    DFYKKALAAG INLRKFDVQL GISLDETTKV SDVEELLAIF TGNKLKASMF 450
    TADIAADEFA AIPESCRRTS KYLTHPVFNE HHSETQMMRY MKKLENKDYS 500
    LTHGMIPLGS CTMKLNAAAE MIPITWPEFG SLHPFAPADQ TKGYQELASK 550
    LSEMLCSVTG YDAFSLQPNS GAQGEYAGLI AIQRYHQHNG DSHRNVCLIP 600
    SSAHGTNPAS AAMVSMKVVV VGCDEKGNVD VEDLKVKIEK HRDNLSCIMI 650
    TYPSTHGVYE EAVREVCDLV HDAGGQVYLD GANMNAQVGL TNPGFIGSDV 700
    SHLNLHKTFC IPHGGGGPGM GPIGVKSHLA PFLPGHVQST SDEGQQYAVS 750
    AAELGSASIL PISYAYIAMM GEEGLTEATK LAILNANYVM ERLRPHYPVL 800
    YRGTEGRIAH ECIIDIRPLK EASGISEEDV AKRLMDYGFH APTMSFPVAG 850
    TLMIEPTESE DLAELDRFCD AMIAIRQEIA RVQEGEWPID DNPLVHAPHT 900
    QADLMETEWN RAYSREIACF PTDHTRASKY WPTVNRVDNV FGDRNLICSC 950
    PSIDSYIED 959
    Length:959
    Mass (Da):104,908
    Last modified:July 5, 2004 - v1
    Checksum:i3155DFA0FF368910
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378679 Genomic DNA. Translation: CAG23195.1.
    RefSeqiYP_132995.1. NC_006371.1.

    Genome annotation databases

    EnsemblBacteriaiCAG23195; CAG23195; PBPRB1324.
    GeneIDi3121484.
    KEGGippr:PBPRB1324.
    PATRICi22941270. VBIPhoPro109272_5201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR378679 Genomic DNA. Translation: CAG23195.1 .
    RefSeqi YP_132995.1. NC_006371.1.

    3D structure databases

    ProteinModelPortali Q6LHN5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 298386.PBPRB1324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG23195 ; CAG23195 ; PBPRB1324 .
    GeneIDi 3121484.
    KEGGi ppr:PBPRB1324.
    PATRICi 22941270. VBIPhoPro109272_5201.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS9.

    Entry informationi

    Entry nameiGCSP_PHOPR
    AccessioniPrimary (citable) accession number: Q6LHN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3