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Q6LHN5

- GCSP_PHOPR

UniProt

Q6LHN5 - GCSP_PHOPR

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, PBPRB1324
Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:PBPRB1324
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000227112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi298386.PBPRB1324.

Structurei

3D structure databases

ProteinModelPortaliQ6LHN5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LHN5-1 [UniParc]FASTAAdd to Basket

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MTDMTLLNAL SDDQDFAGRH NGPNAAQQNI MLKAISAESV EQLIAQTVPA    50
DIRLPEPMKL DPAQSEADML TSLKAIASKN IINRSYIGQG YYNNLTPNVV 100
LRNVLENPGW YTAYTPYQPE ISQGRLESLL NYQQMIMDLT SMELANASLL 150
DEATAAAEAM TLCLRAGKSK SKAFFVSNDL HPQTVDVVRT RAEYIGIEII 200
TGSVEELDNH DVFGALVQYP GTTGSITDLT DIIEKAHAKK TLVAVASDLL 250
ALTLLKAPGE MGADVVIGSA QRFGVPMGFG GPHAGFMATK DKHKRTMPGR 300
VIGVSKDARG NQSLRMAMQT REQHIRREKA TSNICTAQAL LANMAAFYAL 350
YHGPEGLRKI GRRVHHLTAI LAAGLRNSGI ELASDTFFDT ITLNTGKKTD 400
DFYKKALAAG INLRKFDVQL GISLDETTKV SDVEELLAIF TGNKLKASMF 450
TADIAADEFA AIPESCRRTS KYLTHPVFNE HHSETQMMRY MKKLENKDYS 500
LTHGMIPLGS CTMKLNAAAE MIPITWPEFG SLHPFAPADQ TKGYQELASK 550
LSEMLCSVTG YDAFSLQPNS GAQGEYAGLI AIQRYHQHNG DSHRNVCLIP 600
SSAHGTNPAS AAMVSMKVVV VGCDEKGNVD VEDLKVKIEK HRDNLSCIMI 650
TYPSTHGVYE EAVREVCDLV HDAGGQVYLD GANMNAQVGL TNPGFIGSDV 700
SHLNLHKTFC IPHGGGGPGM GPIGVKSHLA PFLPGHVQST SDEGQQYAVS 750
AAELGSASIL PISYAYIAMM GEEGLTEATK LAILNANYVM ERLRPHYPVL 800
YRGTEGRIAH ECIIDIRPLK EASGISEEDV AKRLMDYGFH APTMSFPVAG 850
TLMIEPTESE DLAELDRFCD AMIAIRQEIA RVQEGEWPID DNPLVHAPHT 900
QADLMETEWN RAYSREIACF PTDHTRASKY WPTVNRVDNV FGDRNLICSC 950
PSIDSYIED 959
Length:959
Mass (Da):104,908
Last modified:July 5, 2004 - v1
Checksum:i3155DFA0FF368910
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378679 Genomic DNA. Translation: CAG23195.1.
RefSeqiYP_132995.1. NC_006371.1.

Genome annotation databases

EnsemblBacteriaiCAG23195; CAG23195; PBPRB1324.
GeneIDi3121484.
KEGGippr:PBPRB1324.
PATRICi22941270. VBIPhoPro109272_5201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378679 Genomic DNA. Translation: CAG23195.1 .
RefSeqi YP_132995.1. NC_006371.1.

3D structure databases

ProteinModelPortali Q6LHN5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRB1324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG23195 ; CAG23195 ; PBPRB1324 .
GeneIDi 3121484.
KEGGi ppr:PBPRB1324.
PATRICi 22941270. VBIPhoPro109272_5201.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiGCSP_PHOPR
AccessioniPrimary (citable) accession number: Q6LHN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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