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Q6LGH5

- BETA_PHOPR

UniProt

Q6LGH5 - BETA_PHOPR

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, PBPRB1745
Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei470 – 4701 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:PBPRB1745
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_0000258927Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRB1745.

Structurei

3D structure databases

ProteinModelPortaliQ6LGH5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiPAVEDIN.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LGH5-1 [UniParc]FASTAAdd to Basket

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MNTTYDYIIV GAGSAGCVLA DRLSASGEHY ILLLEAGGSD RSIFIQMPTA    50
LSYPMNSEKY AWQFETQPEA GLDSRSLHCP RGRVLGGSSS INGMVYVRGH 100
ACDYDEWVEQ GAEGWSYQEC LPYFRRAESW IHGEDTYRGG DGPVGTCNGN 150
DMELNPLYQA FIDAGQQAGY PKTDDYNGYQ QEGFGPMHMT VDKGIRASTS 200
NAYLRRAMKR SNLTVRKGVV TRKVLIKNKQ AIGVEIEVGG KVQSVYANTE 250
VLLSAGSVGS PQLLQLSGIG PKAVLEQAGI AVKHDLPGVG ENLQDHLEVY 300
FQYACHQPIT LNSKLGLISK GLIGTRWILQ KDGLGATNHF ESCAFIRSRA 350
GLKWPNIQYH FLPAAMRYDG QAAFDGHGFQ VHVGPNKPQS RGRIWITSAD 400
PHQKPNIEFN YISTEQDKQD WRDCIRLTRE ILAQPAMDDY RGEEIQPGAD 450
ITSDEAMDAW VRQNVESAYH PSCTCKMGSD NDPMTVLNKD CQVRGIDSLR 500
VIDSSVFPTI PNGNLNAPTI MVAEKAADAI LGNTPLSPSN APTWIAPQWE 550
TEQRNGAAQR PMFHQQRK 568
Length:568
Mass (Da):62,698
Last modified:July 5, 2004 - v1
Checksum:iF0017136A0C40B0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378680 Genomic DNA. Translation: CAG23605.1.
RefSeqiYP_133405.1. NC_006371.1.

Genome annotation databases

EnsemblBacteriaiCAG23605; CAG23605; PBPRB1745.
GeneIDi3121754.
KEGGippr:PBPRB1745.
PATRICi22942209. VBIPhoPro109272_5659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378680 Genomic DNA. Translation: CAG23605.1 .
RefSeqi YP_133405.1. NC_006371.1.

3D structure databases

ProteinModelPortali Q6LGH5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRB1745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG23605 ; CAG23605 ; PBPRB1745 .
GeneIDi 3121754.
KEGGi ppr:PBPRB1745.
PATRICi 22942209. VBIPhoPro109272_5659.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi PAVEDIN.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiBETA_PHOPR
AccessioniPrimary (citable) accession number: Q6LGH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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