Reviewed, UniProtKB/Swiss-Prot Q6LGH5 (BETA_PHOPR)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	PBPRB1745

Organism

Photobacterium profundum (Photobacterium sp. (strain SS9)) [Complete proteome] [HAMAP]

Taxonomic identifier

74109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 568	568	Choline dehydrogenase HAMAP MF_00750		PRO_0000258927
Regions
	Nucleotide binding	6 – 35	30	FAD Probable
Sites
	Active site	470	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6LGH5-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F0017136A0C40B0C	FASTA	568	62,698
	10 20 30 40 50 60 MNTTYDYIIV GAGSAGCVLA DRLSASGEHY ILLLEAGGSD RSIFIQMPTA LSYPMNSEKY 70 80 90 100 110 120 AWQFETQPEA GLDSRSLHCP RGRVLGGSSS INGMVYVRGH ACDYDEWVEQ GAEGWSYQEC 130 140 150 160 170 180 LPYFRRAESW IHGEDTYRGG DGPVGTCNGN DMELNPLYQA FIDAGQQAGY PKTDDYNGYQ 190 200 210 220 230 240 QEGFGPMHMT VDKGIRASTS NAYLRRAMKR SNLTVRKGVV TRKVLIKNKQ AIGVEIEVGG 250 260 270 280 290 300 KVQSVYANTE VLLSAGSVGS PQLLQLSGIG PKAVLEQAGI AVKHDLPGVG ENLQDHLEVY 310 320 330 340 350 360 FQYACHQPIT LNSKLGLISK GLIGTRWILQ KDGLGATNHF ESCAFIRSRA GLKWPNIQYH 370 380 390 400 410 420 FLPAAMRYDG QAAFDGHGFQ VHVGPNKPQS RGRIWITSAD PHQKPNIEFN YISTEQDKQD 430 440 450 460 470 480 WRDCIRLTRE ILAQPAMDDY RGEEIQPGAD ITSDEAMDAW VRQNVESAYH PSCTCKMGSD 490 500 510 520 530 540 NDPMTVLNKD CQVRGIDSLR VIDSSVFPTI PNGNLNAPTI MVAEKAADAI LGNTPLSPSN 550 560 APTWIAPQWE TEQRNGAAQR PMFHQQRK

References

[1]

"Life at depth: Photobacterium profundum genome sequence and expression analysis." Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G. Science 307:1459-1461(2005) [PubMed: 15746425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR378680 Genomic DNA. Translation: CAG23605.1.
RefSeq	YP_133405.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3121754.
GenomeReviews	Gene locus PBPRB1745 in contig CR354532_GR.
KEGG	ppr:PBPRB1745.
NMPDR	fig|298386.1.peg.1866.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6LGH5.
Enzyme and pathway databases
BioCyc	PPRO298386:PBPRB1745-MON.
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_PHOPR

Accession

Primary (citable) accession number: Q6LGH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)