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Q6LGH5

- BETA_PHOPR

UniProt

Q6LGH5 - BETA_PHOPR

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei470 – 4701UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:PBPRB1745
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Oxygen-dependent choline dehydrogenasePRO_0000258927Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRB1745.

Structurei

3D structure databases

ProteinModelPortaliQ6LGH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiPAVEDIN.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LGH5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTTYDYIIV GAGSAGCVLA DRLSASGEHY ILLLEAGGSD RSIFIQMPTA
60 70 80 90 100
LSYPMNSEKY AWQFETQPEA GLDSRSLHCP RGRVLGGSSS INGMVYVRGH
110 120 130 140 150
ACDYDEWVEQ GAEGWSYQEC LPYFRRAESW IHGEDTYRGG DGPVGTCNGN
160 170 180 190 200
DMELNPLYQA FIDAGQQAGY PKTDDYNGYQ QEGFGPMHMT VDKGIRASTS
210 220 230 240 250
NAYLRRAMKR SNLTVRKGVV TRKVLIKNKQ AIGVEIEVGG KVQSVYANTE
260 270 280 290 300
VLLSAGSVGS PQLLQLSGIG PKAVLEQAGI AVKHDLPGVG ENLQDHLEVY
310 320 330 340 350
FQYACHQPIT LNSKLGLISK GLIGTRWILQ KDGLGATNHF ESCAFIRSRA
360 370 380 390 400
GLKWPNIQYH FLPAAMRYDG QAAFDGHGFQ VHVGPNKPQS RGRIWITSAD
410 420 430 440 450
PHQKPNIEFN YISTEQDKQD WRDCIRLTRE ILAQPAMDDY RGEEIQPGAD
460 470 480 490 500
ITSDEAMDAW VRQNVESAYH PSCTCKMGSD NDPMTVLNKD CQVRGIDSLR
510 520 530 540 550
VIDSSVFPTI PNGNLNAPTI MVAEKAADAI LGNTPLSPSN APTWIAPQWE
560
TEQRNGAAQR PMFHQQRK
Length:568
Mass (Da):62,698
Last modified:July 5, 2004 - v1
Checksum:iF0017136A0C40B0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378680 Genomic DNA. Translation: CAG23605.1.
RefSeqiYP_133405.1. NC_006371.1.

Genome annotation databases

EnsemblBacteriaiCAG23605; CAG23605; PBPRB1745.
GeneIDi3121754.
KEGGippr:PBPRB1745.
PATRICi22942209. VBIPhoPro109272_5659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378680 Genomic DNA. Translation: CAG23605.1 .
RefSeqi YP_133405.1. NC_006371.1.

3D structure databases

ProteinModelPortali Q6LGH5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRB1745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG23605 ; CAG23605 ; PBPRB1745 .
GeneIDi 3121754.
KEGGi ppr:PBPRB1745.
PATRICi 22942209. VBIPhoPro109272_5659.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi PAVEDIN.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiBETA_PHOPR
AccessioniPrimary (citable) accession number: Q6LGH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3