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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei470Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 35FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:PBPRB1745
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002589271 – 568Oxygen-dependent choline dehydrogenaseAdd BLAST568

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRB1745

Structurei

3D structure databases

ProteinModelPortaliQ6LGH5
SMRiQ6LGH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ6 Bacteria
COG2303 LUCA
HOGENOMiHOG000139600
KOiK00108
OMAiTPQRHAC
OrthoDBiPOG091H04UT

Family and domain databases

Gene3Di3.50.50.60, 4 hits
4.10.450.10, 2 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PANTHERiPTHR11552:SF157 PTHR11552:SF157, 1 hit
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LGH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTYDYIIV GAGSAGCVLA DRLSASGEHY ILLLEAGGSD RSIFIQMPTA
60 70 80 90 100
LSYPMNSEKY AWQFETQPEA GLDSRSLHCP RGRVLGGSSS INGMVYVRGH
110 120 130 140 150
ACDYDEWVEQ GAEGWSYQEC LPYFRRAESW IHGEDTYRGG DGPVGTCNGN
160 170 180 190 200
DMELNPLYQA FIDAGQQAGY PKTDDYNGYQ QEGFGPMHMT VDKGIRASTS
210 220 230 240 250
NAYLRRAMKR SNLTVRKGVV TRKVLIKNKQ AIGVEIEVGG KVQSVYANTE
260 270 280 290 300
VLLSAGSVGS PQLLQLSGIG PKAVLEQAGI AVKHDLPGVG ENLQDHLEVY
310 320 330 340 350
FQYACHQPIT LNSKLGLISK GLIGTRWILQ KDGLGATNHF ESCAFIRSRA
360 370 380 390 400
GLKWPNIQYH FLPAAMRYDG QAAFDGHGFQ VHVGPNKPQS RGRIWITSAD
410 420 430 440 450
PHQKPNIEFN YISTEQDKQD WRDCIRLTRE ILAQPAMDDY RGEEIQPGAD
460 470 480 490 500
ITSDEAMDAW VRQNVESAYH PSCTCKMGSD NDPMTVLNKD CQVRGIDSLR
510 520 530 540 550
VIDSSVFPTI PNGNLNAPTI MVAEKAADAI LGNTPLSPSN APTWIAPQWE
560
TEQRNGAAQR PMFHQQRK
Length:568
Mass (Da):62,698
Last modified:July 5, 2004 - v1
Checksum:iF0017136A0C40B0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378680 Genomic DNA Translation: CAG23605.1
RefSeqiWP_011221752.1, NC_006371.1

Genome annotation databases

EnsemblBacteriaiCAG23605; CAG23605; PBPRB1745
KEGGippr:PBPRB1745

Similar proteinsi

Entry informationi

Entry nameiBETA_PHOPR
AccessioniPrimary (citable) accession number: Q6LGH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health