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Protein

Annexin

Gene

ANXA4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:ANXA4Imported
Synonyms:PIG28Imported
ORF Names:hCG_39482Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24832.

PTM / Processingi

Proteomic databases

MaxQBiQ6LES2.
PeptideAtlasiQ6LES2.

Expressioni

Gene expression databases

BgeeiENSG00000196975.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998726.
STRINGi9606.ENSP00000377833.

Structurei

3D structure databases

SMRiQ6LES2. Positions 3-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation
Contains 4 annexin repeats.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
KOiK17093.
OMAiGMMMPTV.
OrthoDBiEOG091G0H6H.
PhylomeDBiQ6LES2.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002391. AnnexinIV.
[Graphical view]
PANTHERiPTHR10502:SF28. PTHR10502:SF28. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6LES2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMATKGGTV KAASGFNAME DAQTLRKAMK GLGTDEDAII SVLAYRNTAQ
60 70 80 90 100
RQEIRTAYKS TIGRDLIDDL KSELSGNFEQ VIVGMMTPTV LYDVQELRRA
110 120 130 140 150
MKGAGTDEGC LIEILASRTP EEIRRISQTY QQQYGRSLED DIRSDTSFMF
160 170 180 190 200
QRVLVSLSAG GRDEGNYLDD ALVRQDAQDL YEAGEKKWGT DEVKFLTVLC
210 220 230 240 250
SRNRNHLLHV FDEYKRISQK DIEQSIKSET SGSFEDALLA IVKCMRNKSA
260 270 280 290 300
YFAEKLYKSM KGLGTDDNTL IRVMVSRAEI DMLDIRAHFK RLYGKSLYSF
310 320
IKGDTSGDYR KVLLVLCGGD D
Length:321
Mass (Da):36,085
Last modified:July 5, 2004 - v1
Checksum:i59CFD538867E76B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei321 – 3211Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY453398 mRNA. Translation: AAS47515.1.
AC019206 Genomic DNA. Translation: AAY14864.1.
AK315511 mRNA. Translation: BAG37892.1.
CR407681 mRNA. Translation: CAG28609.1.
CH471053 Genomic DNA. Translation: EAW99844.1.
RefSeqiNP_001144.1. NM_001153.4.
NP_001307627.1. NM_001320698.1.
UniGeneiHs.422986.

Genome annotation databases

GeneIDi307.
KEGGihsa:307.
UCSCiuc002sfr.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY453398 mRNA. Translation: AAS47515.1.
AC019206 Genomic DNA. Translation: AAY14864.1.
AK315511 mRNA. Translation: BAG37892.1.
CR407681 mRNA. Translation: CAG28609.1.
CH471053 Genomic DNA. Translation: EAW99844.1.
RefSeqiNP_001144.1. NM_001153.4.
NP_001307627.1. NM_001320698.1.
UniGeneiHs.422986.

3D structure databases

SMRiQ6LES2. Positions 3-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4998726.
STRINGi9606.ENSP00000377833.

Proteomic databases

MaxQBiQ6LES2.
PeptideAtlasiQ6LES2.

Protocols and materials databases

DNASUi307.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi307.
KEGGihsa:307.
UCSCiuc002sfr.5. human.

Organism-specific databases

CTDi307.
PharmGKBiPA24832.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
KOiK17093.
OMAiGMMMPTV.
OrthoDBiEOG091G0H6H.
PhylomeDBiQ6LES2.

Miscellaneous databases

ChiTaRSiANXA4. human.
GenomeRNAii307.

Gene expression databases

BgeeiENSG00000196975.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002391. AnnexinIV.
[Graphical view]
PANTHERiPTHR10502:SF28. PTHR10502:SF28. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6LES2_HUMAN
AccessioniPrimary (citable) accession number: Q6LES2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.