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Protein
Submitted name:

4a-carbinolamine dehydratase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. 4-alpha-hydroxytetrahydrobiopterin dehydratase activity Source: InterPro
  2. phenylalanine 4-monooxygenase activity Source: Ensembl
  3. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: Ensembl
  2. protein heterooligomerization Source: Ensembl
  3. protein homotetramerization Source: Ensembl
  4. regulation of protein homodimerization activity Source: Ensembl
  5. tetrahydrobiopterin biosynthetic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
4a-carbinolamine dehydrataseImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ6LEE2.

Expressioni

Gene expression databases

BgeeiQ6LEE2.
ExpressionAtlasiQ6LEE2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ6LEE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
SUPFAMiSSF55248. SSF55248. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6LEE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
GKAHRLSAEE RDQLLPNLRA VGWNELEGRD AIFKQFHFKD FNR
Length:43
Mass (Da):5,111
Last modified:July 5, 2004 - v1
Checksum:iAF402223C50AF4EF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei43 – 431Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15410 Genomic DNA. Translation: AAA35670.1.
UniGeneiHs.3192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15410 Genomic DNA. Translation: AAA35670.1.
UniGeneiHs.3192.

3D structure databases

ProteinModelPortaliQ6LEE2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6LEE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

BgeeiQ6LEE2.
ExpressionAtlasiQ6LEE2. baseline and differential.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
SUPFAMiSSF55248. SSF55248. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Mutation in the 4a-carbinolamine dehydratase gene leads to mild hyperphenylalaninemia with defective cofactor metabolism."
    Citron B.A., Kaufman S., Milstien S., Naylor E.W., Greene C.L., Davis M.D.
    Am. J. Hum. Genet. 53:768-774(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BloodImported.

Entry informationi

Entry nameiQ6LEE2_HUMAN
AccessioniPrimary (citable) accession number: Q6LEE2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.